outer plexiform layer Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The outer plexiform layer is a layer of neuronal synapses in the retina of the eye. It consists of a dense network of synapses between dendrites of horizontal cells from the inner nuclear layer, and photoreceptor cell inner segments from the outer nuclear layer. It is much thinner than the inner plexiform layer, where horizontal cells synapse with retinal ganglion cells. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003174)
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Genes

368 proteins co-occuring with the tissue outer plexiform layer in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
CALB1 calbindin 1, 28kDa 2.31739
RCVRN recoverin 1.79904
CALB2 calbindin 2 1.76074
PVALB parvalbumin 1.71738
FOXN4 forkhead box N4 1.70943
GRIA4 glutamate receptor, ionotropic, AMPA 4 1.68105
BSN bassoon presynaptic cytomatrix protein 1.67106
TH tyrosine hydroxylase 1.63406
RHO rhodopsin 1.6141
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 1.5138
GJD2 gap junction protein, delta 2, 36kDa 1.51048
OPN4 opsin 4 1.50386
SYP synaptophysin 1.49632
GRM6 glutamate receptor, metabotropic 6 1.46682
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 1.43894
PTF1A pancreas specific transcription factor, 1a 1.40892
VSX2 visual system homeobox 2 1.35268
EGFLAM EGF-like, fibronectin type III and laminin G domains 1.33184
ISL1 ISL LIM homeobox 1 1.28995
DMD dystrophin 1.28367
GJA9 gap junction protein, alpha 9, 59kDa 1.27605
PROX1 prospero homeobox 1 1.2595
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.24878
RS1 retinoschisin 1 1.22692
RGS11 regulator of G-protein signaling 11 1.2238
CHAT choline O-acetyltransferase 1.20689
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.20289
ONECUT2 one cut homeobox 2 1.16693
CPLX4 complexin 4 1.15717
RGS7 regulator of G-protein signaling 7 1.13767
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 1.13147
GPR179 G protein-coupled receptor 179 1.13102
GNB5 guanine nucleotide binding protein (G protein), beta 5 1.10225
KRT73 keratin 73, type II 1.09562
GRIK1 glutamate receptor, ionotropic, kainate 1 1.08811
ATOH7 atonal homolog 7 (Drosophila) 1.07839
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.07265
TMEM237 transmembrane protein 237 1.05897
CTBP2 C-terminal binding protein 2 1.05545
POC1B POC1 centriolar protein B 1.05501
GJC1 gap junction protein, gamma 1, 45kDa 1.04269
SNAP25 synaptosomal-associated protein, 25kDa 1.03214
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 1.02907
STX4 syntaxin 4 1.02644
PAX6 paired box 6 1.01418
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 1.00065
CPLX3 complexin 3 0.99978
GJA10 gap junction protein, alpha 10, 62kDa 0.9889
CABP4 calcium binding protein 4 0.988466
CNGA3 cyclic nucleotide gated channel alpha 3 0.984991
RGS9BP regulator of G protein signaling 9 binding protein 0.974583
NYX nyctalopin 0.970686
POU4F2 POU class 4 homeobox 2 0.952116
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.951685
RIMS2 regulating synaptic membrane exocytosis 2 0.940495
SYN1 synapsin I 0.93577
SALL3 spalt-like transcription factor 3 0.930193
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.929335
IQSEC3 IQ motif and Sec7 domain 3 0.912226
DLG3 discs, large homolog 3 (Drosophila) 0.904127
GFAP glial fibrillary acidic protein 0.901147
CRYGD crystallin, gamma D 0.900296
RLBP1 retinaldehyde binding protein 1 0.893072
LIN7C lin-7 homolog C (C. elegans) 0.89095
CPLX1 complexin 1 0.881627
ELOVL4 ELOVL fatty acid elongase 4 0.875706
GPR75 G protein-coupled receptor 75 0.865577
KRT74 keratin 74, type II 0.861785
SDF4 stromal cell derived factor 4 0.861363
GJA8 gap junction protein, alpha 8, 50kDa 0.860521
PROX2 prospero homeobox 2 0.860521
SST somatostatin 0.859258
POU4F1 POU class 4 homeobox 1 0.844965
UNC119 unc-119 homolog (C. elegans) 0.842447
CCNDBP1 cyclin D-type binding-protein 1 0.842027
TULP1 tubby like protein 1 0.830709
RIT2 Ras-like without CAAX 2 0.825268
MATN3 matrilin 3 0.823175
PANX1 pannexin 1 0.811473
GUCY2C guanylate cyclase 2C 0.810221
GLUL glutamate-ammonia ligase 0.808968
NPR1 natriuretic peptide receptor 1 0.807716
WDR19 WD repeat domain 19 0.807299
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 0.803127
CRX cone-rod homeobox 0.795624
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.780232
LHX1 LIM homeobox 1 0.772759
FAM161A family with sequence similarity 161, member A 0.767368
TUBG1 tubulin, gamma 1 0.764054
OPA1 optic atrophy 1 (autosomal dominant) 0.752057
PALMD palmdelphin 0.750405
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.744627
MEGF11 multiple EGF-like-domains 11 0.738854
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.73803
IQSEC1 IQ motif and Sec7 domain 1 0.737206
GJB2 gap junction protein, beta 2, 26kDa 0.736382
STK33 serine/threonine kinase 33 0.723631
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.721988
RGS6 regulator of G-protein signaling 6 0.721577
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 0.718703
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.718292
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.71583
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.71009
TULP3 tubby like protein 3 0.706812
CLTC clathrin, heavy chain (Hc) 0.703536
KRT71 keratin 71, type II 0.703127
ABAT 4-aminobutyrate aminotransferase 0.702717
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.684735
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.683919
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.683511
ARR3 arrestin 3, retinal (X-arrestin) 0.682695
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.682287
IQSEC2 IQ motif and Sec7 domain 2 0.681471
SON SON DNA binding protein 0.670064
SRPX2 sushi-repeat containing protein, X-linked 2 0.668029
CSAD cysteine sulfinic acid decarboxylase 0.667215
SV2B synaptic vesicle glycoprotein 2B 0.662742
AQP6 aquaporin 6, kidney specific 0.657054
KRT72 keratin 72, type II 0.65543
GRK1 G protein-coupled receptor kinase 1 0.649749
NLGN2 neuroligin 2 0.647316
ONECUT1 one cut homeobox 1 0.640023
ACHE acetylcholinesterase (Yt blood group) 0.630718
BCLAF1 BCL2-associated transcription factor 1 0.627485
RPE65 retinal pigment epithelium-specific protein 65kDa 0.625061
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.618603
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 0.6182
ADCY9 adenylate cyclase 9 0.616183
CABP5 calcium binding protein 5 0.614571
GRM2 glutamate receptor, metabotropic 2 0.612152
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.610943
KIFC3 kinesin family member C3 0.609735
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.606112
MGARP mitochondria-localized glutamic acid-rich protein 0.60249
STX1A syntaxin 1A (brain) 0.599273
BARHL2 BarH-like homeobox 2 0.594451
NUMBL numb homolog (Drosophila)-like 0.583621
GRM7 glutamate receptor, metabotropic 7 0.579617
NRL neural retina leucine zipper 0.572818
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 0.569622
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.568823
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.568025
TAC1 tachykinin, precursor 1 0.564035
SAG S-antigen; retina and pineal gland (arrestin) 0.562042
RPGR retinitis pigmentosa GTPase regulator 0.559254
CDV3 CDV3 homolog (mouse) 0.553683
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.551298
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.549709
ADCY8 adenylate cyclase 8 (brain) 0.544549
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.537021
PNMA2 paraneoplastic Ma antigen 2 0.537021
NCAN neurocan 0.536229
DSCAM Down syndrome cell adhesion molecule 0.534251
SCGN secretagogin, EF-hand calcium binding protein 0.534251
OTX2 orthodenticle homeobox 2 0.53346
VSX1 visual system homeobox 1 0.531089
FGF19 fibroblast growth factor 19 0.530693
MSRB2 methionine sulfoxide reductase B2 0.527928
ARL13B ADP-ribosylation factor-like 13B 0.520829
LRRC4 leucine rich repeat containing 4 0.520829
ATXN7 ataxin 7 0.520041
MEGF10 multiple EGF-like-domains 10 0.517678
PRKCA protein kinase C, alpha 0.51571
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.513743
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 0.51335
NDP Norrie disease (pseudoglioma) 0.503926
SEPT8 septin 8 0.503533
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.495701
PNMT phenylethanolamine N-methyltransferase 0.494136
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.487106
CAPN5 calpain 5 0.485545
MYO5A myosin VA (heavy chain 12, myoxin) 0.481259
UTRN utrophin 0.476589
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.476201
ENO2 enolase 2 (gamma, neuronal) 0.476201
GPM6A glycoprotein M6A 0.466885
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.466111
GDF5 growth differentiation factor 5 0.464948
SV2C synaptic vesicle glycoprotein 2C 0.464174
ADCY4 adenylate cyclase 4 0.464174
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.463787
SCN3A sodium channel, voltage gated, type III alpha subunit 0.463013
GPHN gephyrin 0.45374
NTNG2 netrin G2 0.450657
PCDH9 protocadherin 9 0.448731
ADCY7 adenylate cyclase 7 0.448346
SIGMAR1 sigma non-opioid intracellular receptor 1 0.447961
STX3 syntaxin 3 0.447961
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 0.435289
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.434906
SLC30A10 solute carrier family 30, member 10 0.428401
CEND1 cell cycle exit and neuronal differentiation 1 0.426109
ISL2 ISL LIM homeobox 2 0.426109
MYO6 myosin VI 0.425726
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 0.424581
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.424581
ADCY5 adenylate cyclase 5 0.421148
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.41848
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.412771
FGF2 fibroblast growth factor 2 (basic) 0.41087
DRD2 dopamine receptor D2 0.408972
NEUROD1 neuronal differentiation 1 0.407073
ADCY1 adenylate cyclase 1 (brain) 0.404797
ADCY3 adenylate cyclase 3 0.402144
DTNB dystrobrevin, beta 0.398357
DNAH8 dynein, axonemal, heavy chain 8 0.397222
SYNPR synaptoporin 0.396844
MAP2 microtubule-associated protein 2 0.396844
VIP vasoactive intestinal peptide 0.394576
PRCD progressive rod-cone degeneration 0.390421
TFG TRK-fused gene 0.389289
RAB3C RAB3C, member RAS oncogene family 0.387404
SPTBN2 spectrin, beta, non-erythrocytic 2 0.386273
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 0.386273
CABP1 calcium binding protein 1 0.382884
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.379499
DMTN dematin actin binding protein 0.374993
CRYAA crystallin, alpha A 0.373868
FRY furry homolog (Drosophila) 0.373118
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.372743
LHX3 LIM homeobox 3 0.37087
CNR1 cannabinoid receptor 1 (brain) 0.368624
NEUROD4 neuronal differentiation 4 0.368624
DLG1 discs, large homolog 1 (Drosophila) 0.367876
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.367502
GRM5 glutamate receptor, metabotropic 5 0.362646
CLDN14 claudin 14 0.357802
PLXNA3 plexin A3 0.35334
ADCY10 adenylate cyclase 10 (soluble) 0.352227
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.352227
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.350743
PLBD2 phospholipase B domain containing 2 0.34926
GRM1 glutamate receptor, metabotropic 1 0.348889
CNGB3 cyclic nucleotide gated channel beta 3 0.345928
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.345928
OXR1 oxidation resistance 1 0.345558
MPDZ multiple PDZ domain protein 0.345188
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.344079
ADCY2 adenylate cyclase 2 (brain) 0.342602
ANO2 anoctamin 2, calcium activated chloride channel 0.341863
FGFRL1 fibroblast growth factor receptor-like 1 0.340388
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.33965
PLCH2 phospholipase C, eta 2 0.339282
MGAM maltase-glucoamylase 0.338914
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.333763
LMNB1 lamin B1 0.333763
DNM1 dynamin 1 0.333396
CNTF ciliary neurotrophic factor 0.328994
MORF4 mortality factor 4 (pseudogene) 0.327164
AQP11 aquaporin 11 0.326798
PLXNA4 plexin A4 0.32497
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.323874
PLA2G5 phospholipase A2, group V 0.323144
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.322779
SKAP2 src kinase associated phosphoprotein 2 0.322414
ADCY6 adenylate cyclase 6 0.321685
NLGN3 neuroligin 3 0.317315
TMOD1 tropomodulin 1 0.316224
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.315861
RORB RAR-related orphan receptor B 0.315135
NT5E 5'-nucleotidase, ecto (CD73) 0.31187
A1BG alpha-1-B glycoprotein 0.307889
CRYAB crystallin, alpha B 0.307889
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.301758
VEGFA vascular endothelial growth factor A 0.30032
GRM4 glutamate receptor, metabotropic 4 0.297806
LIN7A lin-7 homolog A (C. elegans) 0.297089
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 0.29673
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.296013
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 0.294223
CDH8 cadherin 8, type 2 0.292793
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 0.292079
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.28887
PCNA proliferating cell nuclear antigen 0.287803
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.286381
MYO10 myosin X 0.285316
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.284962
RIPK3 receptor-interacting serine-threonine kinase 3 0.282837
TECTA tectorin alpha 0.281776
OPLAH 5-oxoprolinase (ATP-hydrolysing) 0.280012
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.278603
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.276145
RERE arginine-glutamic acid dipeptide (RE) repeats 0.272997
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.270909
RND1 Rho family GTPase 1 0.270909
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.268137
MIR133B microRNA 133b 0.267791
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.266757
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.266413
FGFR1 fibroblast growth factor receptor 1 0.266413
KCNIP4 Kv channel interacting protein 4 0.263669
CNTFR ciliary neurotrophic factor receptor 0.261284
NRTN neurturin 0.259929
GCAT glycine C-acetyltransferase 0.257907
SUFU suppressor of fused homolog (Drosophila) 0.257572
SNAP23 synaptosomal-associated protein, 23kDa 0.253578
RB1 retinoblastoma 1 0.250953
RAB3B RAB3B, member RAS oncogene family 0.249977
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.248361
MTNR1A melatonin receptor 1A 0.248361
DLL4 delta-like 4 (Drosophila) 0.245491
CHRM4 cholinergic receptor, muscarinic 4 0.245491
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.243605
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.242054
PANX2 pannexin 2 0.241132
MTNR1B melatonin receptor 1B 0.240216
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.238108
GLS glutaminase 0.237216
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.236921
SYT2 synaptotagmin II 0.236921
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.235167
CNTN2 contactin 2 (axonal) 0.229568
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.22797
CNGB1 cyclic nucleotide gated channel beta 1 0.22797
RPH3A rabphilin 3A 0.227186
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.226155
ROM1 retinal outer segment membrane protein 1 0.2259
HPCA hippocalcin 0.225144
NTS neurotensin 0.22415
TNC tenascin C 0.223906
NKX2-1 NK2 homeobox 1 0.223662
PCDH11Y protocadherin 11 Y-linked 0.223177
MAP1B microtubule-associated protein 1B 0.221755
TMOD4 tropomodulin 4 (muscle) 0.220152
OCLN occludin 0.217974
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.216528
DES desmin 0.216325
PCDH11X protocadherin 11 X-linked 0.21573
NLGN1 neuroligin 1 0.215147
PMM2 phosphomannomutase 2 0.214576
DDO D-aspartate oxidase 0.21365
SV2A synaptic vesicle glycoprotein 2A 0.212936
MRPL49 mitochondrial ribosomal protein L49 0.212936
IARS isoleucyl-tRNA synthetase 0.212936
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.194091
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.194078
GRIP1 glutamate receptor interacting protein 1 0.193944
PSPN persephin 0.193917
NTN1 netrin 1 0.193344
MDK midkine (neurite growth-promoting factor 2) 0.193213
BHLHE22 basic helix-loop-helix family, member e22 0.193154
KRT81 keratin 81, type II 0.192793
NCS1 neuronal calcium sensor 1 0.1927
POU4F3 POU class 4 homeobox 3 0.192654
CNTNAP1 contactin associated protein 1 0.192591
WFS1 Wolfram syndrome 1 (wolframin) 0.192528
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.192401
CA2 carbonic anhydrase II 0.192305
HOPX HOP homeobox 0.192059
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.192059
GDNF glial cell derived neurotrophic factor 0.191892
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.191875
AQP4 aquaporin 4 0.191757
KRT12 keratin 12, type I 0.191444
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.191338
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.191231
HM13 histocompatibility (minor) 13 0.191068
DCX doublecortin 0.191031
METTL13 methyltransferase like 13 0.190994
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.190976
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.190734
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.190696
GDF6 growth differentiation factor 6 0.190505
F12 coagulation factor XII (Hageman factor) 0.190389
DICER1 dicer 1, ribonuclease type III 0.190389
ASCL1 achaete-scute family bHLH transcription factor 1 0.190232
TFCP2 transcription factor CP2 0.189951
GAP43 growth associated protein 43 0.189808