ouabain-2656 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ouabain-2656 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ADM adrenomedullin
AKAP9 A kinase (PRKA) anchor protein 9
AMOTL2 angiomotin like 2
ARHGAP35 Rho GTPase activating protein 35
ATF3 activating transcription factor 3
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
AVPI1 arginine vasopressin-induced 1
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CA4 carbonic anhydrase IV
CD80 CD80 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CLK1 CDC-like kinase 1
CLK4 CDC-like kinase 4
COL1A1 collagen, type I, alpha 1
CXORF21 chromosome X open reading frame 21
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUX1 double homeobox 1
EED embryonic ectoderm development
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EPHA2 EPH receptor A2
ETNK2 ethanolamine kinase 2
FAM46A family with sequence similarity 46, member A
FLCN folliculin
GADD45B growth arrest and DNA-damage-inducible, beta
GFER growth factor, augmenter of liver regeneration
GON4L gon-4-like (C. elegans)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREB1L growth regulation by estrogen in breast cancer-like
GTPBP1 GTP binding protein 1
HIST1H1C histone cluster 1, H1c
HIST1H1T histone cluster 1, H1t
HIST2H2BE histone cluster 2, H2be
HOXC13 homeobox C13
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IL6 interleukin 6
IP6K2 inositol hexakisphosphate kinase 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLHL20 kelch-like family member 20
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
N4BP2L2 NEDD4 binding protein 2-like 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PER1 period circadian clock 1
PLAC4 placenta-specific 4
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
POMT2 protein-O-mannosyltransferase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM48 RNA binding motif protein 48
RBM5 RNA binding motif protein 5
RIMS2 regulating synaptic membrane exocytosis 2
RND3 Rho family GTPase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX1 runt-related transcription factor 1
S100A9 S100 calcium binding protein A9
SERTAD3 SERTA domain containing 3
SFPQ splicing factor proline/glutamine-rich
SIGLEC7 sialic acid binding Ig-like lectin 7
SKIL SKI-like proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC38A2 solute carrier family 38, member 2
SLN sarcolipin
SSBP1 single-stranded DNA binding protein 1, mitochondrial
TBX2 T-box 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB2 transforming growth factor, beta 2
TXNIP thioredoxin interacting protein
WSB1 WD repeat and SOCS box containing 1
ZFAND6 zinc finger, AN1-type domain 6
ZNF143 zinc finger protein 143
ZNF335 zinc finger protein 335
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADORA2B adenosine A2b receptor
AMIGO2 adhesion molecule with Ig-like domain 2
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARMCX1 armadillo repeat containing, X-linked 1
ASB13 ankyrin repeat and SOCS box containing 13
BATF basic leucine zipper transcription factor, ATF-like
C6ORF47 chromosome 6 open reading frame 47
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHMP7 charged multivesicular body protein 7
CLDN9 claudin 9
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
DEAF1 DEAF1 transcription factor
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DTWD1 DTW domain containing 1
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFTUD1 elongation factor Tu GTP binding domain containing 1
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ERCC6L excision repair cross-complementation group 6-like
ERO1L ERO1-like (S. cerevisiae)
FADD Fas (TNFRSF6)-associated via death domain
FAM192A family with sequence similarity 192, member A
FAM50B family with sequence similarity 50, member B
FAM53B family with sequence similarity 53, member B
FANCF Fanconi anemia, complementation group F
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN6 gem (nuclear organelle) associated protein 6
GLRX2 glutaredoxin 2
GMIP GEM interacting protein
GPR19 G protein-coupled receptor 19
H2AFJ H2A histone family, member J
HIRIP3 HIRA interacting protein 3
HPS5 Hermansky-Pudlak syndrome 5
ICE2 interactor of little elongation complex ELL subunit 2
IFRD1 interferon-related developmental regulator 1
KRCC1 lysine-rich coiled-coil 1
LIAS lipoic acid synthetase
LRRC8D leucine rich repeat containing 8 family, member D
MAGEH1 melanoma antigen family H1
MAK16 MAK16 homolog (S. cerevisiae)
MAT2A methionine adenosyltransferase II, alpha
MCRS1 microspherule protein 1
METTL13 methyltransferase like 13
MINA MYC induced nuclear antigen
MKKS McKusick-Kaufman syndrome
MNS1 meiosis-specific nuclear structural 1
MREG melanoregulin
MSX1 msh homeobox 1
MXD3 MAX dimerization protein 3
NAP1L2 nucleosome assembly protein 1-like 2
NELFE negative elongation factor complex member E
NOL8 nucleolar protein 8
OXSM 3-oxoacyl-ACP synthase, mitochondrial
PAGR1 PAXIP1 associated glutamate-rich protein 1
PALB2 partner and localizer of BRCA2
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDCD5 programmed cell death 5
PLEKHO1 pleckstrin homology domain containing, family O member 1
POGK pogo transposable element with KRAB domain
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRMT7 protein arginine methyltransferase 7
PRR7 proline rich 7 (synaptic)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
RIBC2 RIB43A domain with coiled-coils 2
RPP40 ribonuclease P/MRP 40kDa subunit
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae)
RSAD1 radical S-adenosyl methionine domain containing 1
SACS sacsin molecular chaperone
SALL2 spalt-like transcription factor 2
SEH1L SEH1-like (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SLC46A3 solute carrier family 46, member 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
STARD7 StAR-related lipid transfer (START) domain containing 7
THYN1 thymocyte nuclear protein 1
TRAPPC12 trafficking protein particle complex 12
TRIM16 tripartite motif containing 16
TRIM27 tripartite motif containing 27
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
WDR3 WD repeat domain 3
XBP1 X-box binding protein 1
ZBED8 zinc finger, BED-type containing 8
ZC3H4 zinc finger CCCH-type containing 4
ZFP30 ZFP30 zinc finger protein
ZNF184 zinc finger protein 184
ZNF23 zinc finger protein 23
ZNF239 zinc finger protein 239
ZNF250 zinc finger protein 250
ZNF33B zinc finger protein 33B