osteoarthritis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans. (Experimental Factor Ontology, EFO_0002506)
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Genes

314 genes co-occuring with the biological term osteoarthritis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACAN aggrecan
ACE angiotensin I converting enzyme
ADAM12 ADAM metallopeptidase domain 12
ADAM15 ADAM metallopeptidase domain 15
ADAM8 ADAM metallopeptidase domain 8
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
AGER advanced glycosylation end product-specific receptor
AHSG alpha-2-HS-glycoprotein
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX15 arachidonate 15-lipoxygenase
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APLN apelin
APOA1 apolipoprotein A-I
APOB apolipoprotein B
ASPN asporin
ATF3 activating transcription factor 3
B2M beta-2-microglobulin
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAG1 BCL2-associated athanogene
BAG6 BCL2-associated athanogene 6
BBC3 BCL2 binding component 3
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDNF brain-derived neurotrophic factor
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BMP7 bone morphogenetic protein 7
BTNL2 butyrophilin-like 2
CA1 carbonic anhydrase I
CALCA calcitonin-related polypeptide alpha
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CAT catalase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCR6 chemokine (C-C motif) receptor 6
CD247 CD247 molecule
CD44 CD44 molecule (Indian blood group)
CD53 CD53 molecule
CHAT choline O-acetyltransferase
CHGA chromogranin A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHUK conserved helix-loop-helix ubiquitous kinase
CILP2 cartilage intermediate layer protein 2
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COG5 component of oligomeric golgi complex 5
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL6A4P1 collagen, type VI, alpha 4 pseudogene 1
COL9A2 collagen, type IX, alpha 2
COMP cartilage oligomeric matrix protein
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CTSS cathepsin S
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDR2 discoidin domain receptor tyrosine kinase 2
DEFB104A defensin, beta 104A
DEFB104B defensin, beta 104B
DEFB4A defensin, beta 4A
DIO2 deiodinase, iodothyronine, type II
DIO3 deiodinase, iodothyronine, type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMP1 dentin matrix acidic phosphoprotein 1
DOT1L DOT1-like histone H3K79 methyltransferase
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNB2 ephrin-B2
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENG endoglin
EPAS1 endothelial PAS domain protein 1
EPHB4 EPH receptor B4
ERVK-18 endogenous retrovirus group K, member 18
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRA estrogen-related receptor alpha
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FAP fibroblast activation protein, alpha
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FHL2 four and a half LIM domains 2
FLT1 fms-related tyrosine kinase 1
FOLR2 folate receptor 2 (fetal)
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FPR2 formyl peptide receptor 2
FRZB frizzled-related protein
FTO fat mass and obesity associated
FZD5 frizzled class receptor 5
GAS5 growth arrest-specific 5 (non-protein coding)
GDF5 growth differentiation factor 5
GHR growth hormone receptor
GREM1 gremlin 1, DAN family BMP antagonist
GRP gastrin-releasing peptide
GSTT1 glutathione S-transferase theta 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HBP1 HMG-box transcription factor 1
HDAC1 histone deacetylase 1
HDAC7 histone deacetylase 7
HES5 hes family bHLH transcription factor 5
HFE hemochromatosis
HHIP hedgehog interacting protein
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HPSE heparanase
HRH4 histamine receptor H4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTRA1 HtrA serine peptidase 1
IBSP integrin-binding sialoprotein
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IHH indian hedgehog
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
IL12B interleukin 12B
IL17A interleukin 17A
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL22 interleukin 22
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
IL7 interleukin 7
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITLN1 intelectin 1 (galactofuranose binding)
JAG1 jagged 1
JUN jun proto-oncogene
KCNIP3 Kv channel interacting protein 3, calsenilin
KDR kinase insert domain receptor
KL klotho
KLF5 Kruppel-like factor 5 (intestinal)
LCN2 lipocalin 2
LEP leptin
LMNA lamin A/C
LPAR1 lysophosphatidic acid receptor 1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRP5 low density lipoprotein receptor-related protein 5
LTBP1 latent transforming growth factor beta binding protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MATN3 matrilin 3
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MCAM melanoma cell adhesion molecule
MCF2L MCF.2 cell line derived transforming sequence-like
MEFV Mediterranean fever
MGP matrix Gla protein
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR127 microRNA 127
MIR140 microRNA 140
MIR146A microRNA 146a
MIR149 microRNA 149
MIR155 microRNA 155
MIR181A1 microRNA 181a-1
MIR199A1 microRNA 199a-1
MIR199A2 microRNA 199a-2
MIR21 microRNA 21
MIR223 microRNA 223
MIR9-1 microRNA 9-1
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAMPT nicotinamide phosphoribosyltransferase
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NME8 NME/NM23 family member 8
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NR1D1 nuclear receptor subfamily 1, group D, member 1
NUCB2 nucleobindin 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PADI4 peptidyl arginine deiminase, type IV
PCSK6 proprotein convertase subtilisin/kexin type 6
PDCD5 programmed cell death 5
PEPD peptidase D
PGF placental growth factor
PGK1 phosphoglycerate kinase 1
PITX1 paired-like homeodomain 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAU plasminogen activator, urokinase
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PRDX5 peroxiredoxin 5
PRG4 proteoglycan 4
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PRTG protogenin
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH1R parathyroid hormone 1 receptor
PTHLH parathyroid hormone-like hormone
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
RHOB ras homolog family member B
ROR2 receptor tyrosine kinase-like orphan receptor 2
RSPO2 R-spondin 2
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAA1 serum amyloid A1
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETDB1 SET domain, bifurcated 1
SIRT1 sirtuin 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SOST sclerostin
SOX5 SRY (sex determining region Y)-box 5
SOX6 SRY (sex determining region Y)-box 6
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SREBF2 sterol regulatory element binding transcription factor 2
SULF1 sulfatase 1
SULF2 sulfatase 2
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TM2D3 TM2 domain containing 3
TMSB4X thymosin beta 4, X-linked
TNC tenascin C
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TPI1 triosephosphate isomerase 1
TPSAB1 tryptase alpha/beta 1
TRAPPC2 trafficking protein particle complex 2
TRIB3 tribbles pseudokinase 3
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TTR transthyretin
TWIST1 twist family bHLH transcription factor 1
UNC5B unc-5 homolog B (C. elegans)
UNC5C unc-5 homolog C (C. elegans)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIM vimentin
VIP vasoactive intestinal peptide
WISP1 WNT1 inducible signaling pathway protein 1
WISP3 WNT1 inducible signaling pathway protein 3
WNT3A wingless-type MMTV integration site family, member 3A
XBP1 X-box binding protein 1
XCL2 chemokine (C motif) ligand 2
XYLT1 xylosyltransferase I
ZFP36 ZFP36 ring finger protein