osteoarthritis Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An arthritis that has_material_basis_in worn out cartilage located_in joint. (Human Disease Ontology, DOID_8398)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0002758
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Genes

162 genes associated with the osteoarthritis phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
GDF5 growth differentiation factor 5 1.61591
DOT1L DOT1-like histone H3K79 methyltransferase 1.51005
GLT8D1 glycosyltransferase 8 domain containing 1 1.41309
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 1.28282
MCF2L MCF.2 cell line derived transforming sequence-like 1.21853
COL6A4P1 collagen, type VI, alpha 4 pseudogene 1 1.21006
AVL9 AVL9 homolog (S. cerevisiase) 1.18334
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 1.17192
COG5 component of oligomeric golgi complex 5 1.16177
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.11342
KIRREL3 kin of IRRE like 3 (Drosophila) 1.10834
CPNE4 copine IV 1.10124
COL2A1 collagen, type II, alpha 1 1.09477
STMN2 stathmin 2 1.0918
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 1.07223
UNC5C unc-5 homolog C (C. elegans) 1.07183
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1.07133
SCN3A sodium channel, voltage gated, type III alpha subunit 1.07064
NAV3 neuron navigator 3 1.06567
RYR3 ryanodine receptor 3 1.06061
OPCML opioid binding protein/cell adhesion molecule-like 1.058
SORBS2 sorbin and SH3 domain containing 2 1.04955
MYOF myoferlin 1.04896
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 1.04448
SAXO1 stabilizer of axonemal microtubules 1 1.03114
PTPRD protein tyrosine phosphatase, receptor type, D 1.02683
FMN1 formin 1 1.02549
AGBL4 ATP/GTP binding protein-like 4 1.02082
PTPRT protein tyrosine phosphatase, receptor type, T 1.02082
SENP6 SUMO1/sentrin specific peptidase 6 1.01337
ZMIZ1 zinc finger, MIZ-type containing 1 1.0118
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 1.01065
GSAP gamma-secretase activating protein 1.00952
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.995928
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.988702
WWOX WW domain containing oxidoreductase 0.987473
ASTN2 astrotactin 2 0.984794
FAM126A family with sequence similarity 126, member A 0.978851
MAST4 microtubule associated serine/threonine kinase family member 4 0.976371
CATSPER3 cation channel, sperm associated 3 0.975463
SPATA6L spermatogenesis associated 6-like 0.972518
SPATA31E1 SPATA31 subfamily E, member 1 0.971944
AUP1 ancient ubiquitous protein 1 0.969971
TP63 tumor protein p63 0.968323
TBC1D31 TBC1 domain family, member 31 0.966714
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.962749
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.962153
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 0.96156
RNF115 ring finger protein 115 0.955595
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 0.953703
NLGN1 neuroligin 1 0.951596
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.949544
ABLIM3 actin binding LIM protein family, member 3 0.945838
COL11A1 collagen, type XI, alpha 1 0.945598
FTO fat mass and obesity associated 0.942765
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.940413
ACAN aggrecan 0.932233
THSD7B thrombospondin, type I, domain containing 7B 0.931997
TSPYL5 TSPY-like 5 0.924345
ENAH enabled homolog (Drosophila) 0.923489
USP3 ubiquitin specific peptidase 3 0.91506
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 0.912105
BLM Bloom syndrome, RecQ helicase-like 0.907455
TUSC3 tumor suppressor candidate 3 0.90474
EIF3F eukaryotic translation initiation factor 3, subunit F 0.901922
MN1 meningioma (disrupted in balanced translocation) 1 0.900274
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.899551
PARVA parvin, alpha 0.896372
OLFM3 olfactomedin 3 0.890832
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.888782
LZTR1 leucine-zipper-like transcription regulator 1 0.886085
MSRA methionine sulfoxide reductase A 0.884276
WWC1 WW and C2 domain containing 1 0.883951
SLAIN2 SLAIN motif family, member 2 0.882823
TRIM41 tripartite motif containing 41 0.881709
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 0.880453
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.879831
CDH5 cadherin 5, type 2 (vascular endothelium) 0.879368
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.878449
CCDC91 coiled-coil domain containing 91 0.877539
RGMA repulsive guidance molecule family member a 0.876787
NRP1 neuropilin 1 0.874426
CTNND2 catenin (cadherin-associated protein), delta 2 0.873412
APCDD1 adenomatosis polyposis coli down-regulated 1 0.868649
WIPF1 WAS/WASL interacting protein family, member 1 0.867565
OSBPL2 oxysterol binding protein-like 2 0.866761
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.864783
PPA2 pyrophosphatase (inorganic) 2 0.862428
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 0.862428
ERCC4 excision repair cross-complementation group 4 0.85862
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.858496
LIMS1 LIM and senescent cell antigen-like domains 1 0.857387
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.857142
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.856777
GNA14 guanine nucleotide binding protein (G protein), alpha 14 0.855809
GRK5 G protein-coupled receptor kinase 5 0.855449
SEC14L5 SEC14-like 5 (S. cerevisiae) 0.853437
GRIK4 glutamate receptor, ionotropic, kainate 4 0.851243
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 0.850675
MPRIP myosin phosphatase Rho interacting protein 0.850675
FAM172A family with sequence similarity 172, member A 0.850111
LOC100506446 uncharacterized LOC100506446 0.849438
LLGL1 lethal giant larvae homolog 1 (Drosophila) 0.83069
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.814503
PPT1 palmitoyl-protein thioesterase 1 0.807106
CREB3L2 cAMP responsive element binding protein 3-like 2 0.799669
NCK2 NCK adaptor protein 2 0.771787
LOC643542 uncharacterized LOC643542 0.771265
RNF152 ring finger protein 152 0.770746
JAZF1 JAZF zinc finger 1 0.760343
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.760343
NTM neurotrimin 0.759303
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.758275
CAPN7 calpain 7 0.752335
FBN2 fibrillin 2 0.750909
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.749042
NELL2 NEL-like 2 (chicken) 0.723288
RAB5A RAB5A, member RAS oncogene family 0.721344
CHN2 chimerin 2 0.720196
WRB tryptophan rich basic protein 0.718314
OARD1 O-acyl-ADP-ribose deacylase 1 0.717203
APOPT1 apoptogenic 1, mitochondrial 0.714303
NRP2 neuropilin 2 0.712186
LOC100128714 uncharacterized LOC100128714 0.699708
PTBP3 polypyrimidine tract binding protein 3 0.696021
FHIT fragile histidine triad 0.680272
IL1RAP interleukin 1 receptor accessory protein 0.67722
SCCPDH saccharopine dehydrogenase (putative) 0.674828
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.656005
MMP20 matrix metallopeptidase 20 0.65576
OR8A1 olfactory receptor, family 8, subfamily A, member 1 0.638927
KIAA1217 KIAA1217 0.635061
WSCD2 WSC domain containing 2 0.630049
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.628781
ELL elongation factor RNA polymerase II 0.603793
NRG1 neuregulin 1 0.586726
NUPL1 nucleoporin like 1 0.584153
FUT2 fucosyltransferase 2 (secretor status included) 0.57779
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 0.573577
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.563675
ALOX15 arachidonate 15-lipoxygenase 0.542984
TMEM51 transmembrane protein 51 0.535185
AQR aquarius intron-binding spliceosomal factor 0.53407
TMEM132C transmembrane protein 132C 0.530515
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.521572
TBX21 T-box 21 0.516251
JAKMIP1 janus kinase and microtubule interacting protein 1 0.505592
PSAT1 phosphoserine aminotransferase 1 0.502867
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.502867
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 0.502058
CPVL carboxypeptidase, vitellogenic-like 0.500023
ZNF608 zinc finger protein 608 0.497987
PRKCA protein kinase C, alpha 0.497391
PITRM1 pitrilysin metallopeptidase 1 0.494882
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.490542
ISM1 isthmin 1, angiogenesis inhibitor 0.487836
BTNL2 butyrophilin-like 2 0.410522
DNAH10 dynein, axonemal, heavy chain 10 0.370544
PARD3B par-3 family cell polarity regulator beta 0.360941
NACA2 nascent polypeptide-associated complex alpha subunit 2 0.358325
LOC100507175 uncharacterized LOC100507175 0.355233
PHF2 PHD finger protein 2 0.340946