osteoarthritis Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description An arthritis that has_material_basis_in worn out cartilage located_in joint. (Human Disease Ontology, DOID_8398)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:8398
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Genes

162 genes associated with the disease osteoarthritis in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
GDF5 growth differentiation factor 5 1.7256
DOT1L DOT1-like histone H3K79 methyltransferase 1.63837
GLT8D1 glycosyltransferase 8 domain containing 1 1.55364
CAMK2B calcium/calmodulin-dependent protein kinase II beta 1.51636
BTNL2 butyrophilin-like 2 1.45471
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 1.45471
MCF2L MCF.2 cell line derived transforming sequence-like 1.39396
COL6A4P1 collagen, type VI, alpha 4 pseudogene 1 1.38478
AVL9 AVL9 homolog (S. cerevisiase) 1.35377
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 1.33878
COG5 component of oligomeric golgi complex 5 1.32598
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.2712
KIRREL3 kin of IRRE like 3 (Drosophila) 1.26546
CPNE4 copine IV 1.25704
COL2A1 collagen, type II, alpha 1 1.25007
STMN2 stathmin 2 1.24648
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 1.22504
UNC5C unc-5 homolog C (C. elegans) 1.22464
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1.22414
SCN3A sodium channel, voltage gated, type III alpha subunit 1.22345
NAV3 neuron navigator 3 1.21798
RYR3 ryanodine receptor 3 1.21221
OPCML opioid binding protein/cell adhesion molecule-like 1.20947
SORBS2 sorbin and SH3 domain containing 2 1.20039
MYOF myoferlin 1.19974
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 1.19481
SAXO1 stabilizer of axonemal microtubules 1 1.18008
PTPRD protein tyrosine phosphatase, receptor type, D 1.17539
FMN1 formin 1 1.17391
AGBL4 ATP/GTP binding protein-like 4 1.16856
PTPRT protein tyrosine phosphatase, receptor type, T 1.16856
SENP6 SUMO1/sentrin specific peptidase 6 1.16005
ZMIZ1 zinc finger, MIZ-type containing 1 1.15841
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 1.1572
GSAP gamma-secretase activating protein 1.15602
DNAH10 dynein, axonemal, heavy chain 10 1.14463
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 1.1395
PLEKHA7 pleckstrin homology domain containing, family A member 7 1.13087
WWOX WW domain containing oxidoreductase 1.1293
ASTN2 astrotactin 2 1.12589
FAM126A family with sequence similarity 126, member A 1.11914
MAST4 microtubule associated serine/threonine kinase family member 4 1.11647
CATSPER3 cation channel, sperm associated 3 1.11549
SPATA6L spermatogenesis associated 6-like 1.11197
SPATA31E1 SPATA31 subfamily E, member 1 1.11123
AUP1 ancient ubiquitous protein 1 1.1087
TP63 tumor protein p63 1.10659
TBC1D31 TBC1 domain family, member 31 1.10453
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 1.09959
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 1.09895
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 1.09832
RNF115 ring finger protein 115 1.09196
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 1.08994
NLGN1 neuroligin 1 1.08731
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 1.08467
ABLIM3 actin binding LIM protein family, member 3 1.07992
COL11A1 collagen, type XI, alpha 1 1.07961
FTO fat mass and obesity associated 1.07599
CAMK2D calcium/calmodulin-dependent protein kinase II delta 1.07307
ACAN aggrecan 1.06405
THSD7B thrombospondin, type I, domain containing 7B 1.06379
TSPYL5 TSPY-like 5 1.05435
ENAH enabled homolog (Drosophila) 1.05325
USP3 ubiquitin specific peptidase 3 1.04266
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 1.03929
BLM Bloom syndrome, RecQ helicase-like 1.03399
TUSC3 tumor suppressor candidate 3 1.03089
EIF3F eukaryotic translation initiation factor 3, subunit F 1.02731
MN1 meningioma (disrupted in balanced translocation) 1 1.02522
PARD3B par-3 family cell polarity regulator beta 1.02476
PARVA parvin, alpha 1.02027
OLFM3 olfactomedin 3 1.01328
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 1.01084
LZTR1 leucine-zipper-like transcription regulator 1 1.00769
MSRA methionine sulfoxide reductase A 1.00558
WWC1 WW and C2 domain containing 1 1.0052
SLAIN2 SLAIN motif family, member 2 1.00388
TRIM41 tripartite motif containing 41 1.00258
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa 1.00111
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 1.00039
CDH5 cadherin 5, type 2 (vascular endothelium) 0.99985
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.998763
CCDC91 coiled-coil domain containing 91 0.997656
RGMA repulsive guidance molecule family member a 0.996743
NRP1 neuropilin 1 0.993874
CTNND2 catenin (cadherin-associated protein), delta 2 0.992643
APCDD1 adenomatosis polyposis coli down-regulated 1 0.98687
NACA2 nascent polypeptide-associated complex alpha subunit 2 0.986376
WIPF1 WAS/WASL interacting protein family, member 1 0.985558
OSBPL2 oxysterol binding protein-like 2 0.984586
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.982194
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 0.979397
PPA2 pyrophosphatase (inorganic) 2 0.979397
ERCC4 excision repair cross-complementation group 4 0.974905
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.974758
LIMS1 LIM and senescent cell antigen-like domains 1 0.973451
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.973163
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.972732
GNA14 guanine nucleotide binding protein (G protein), alpha 14 0.971593
GRK5 G protein-coupled receptor kinase 5 0.971169
SEC14L5 SEC14-like 5 (S. cerevisiae) 0.968801
GRIK4 glutamate receptor, ionotropic, kainate 4 0.966295
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 0.965651
MPRIP myosin phosphatase Rho interacting protein 0.965651
FAM172A family with sequence similarity 172, member A 0.965012
LOC100506446 uncharacterized LOC100506446 0.964251
LOC100507175 uncharacterized LOC100507175 0.947208
LLGL1 lethal giant larvae homolog 1 (Drosophila) 0.943097
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.925175
PPT1 palmitoyl-protein thioesterase 1 0.917442
CREB3L2 cAMP responsive element binding protein 3-like 2 0.909246
NCK2 NCK adaptor protein 2 0.879151
LOC643542 uncharacterized LOC643542 0.878562
RNF152 ring finger protein 152 0.877977
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.866989
JAZF1 JAZF zinc finger 1 0.866989
NTM neurotrimin 0.865959
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.86494
CAPN7 calpain 7 0.858922
FBN2 fibrillin 2 0.857354
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.855302
NELL2 NEL-like 2 (chicken) 0.828571
RAB5A RAB5A, member RAS oncogene family 0.826445
CHN2 chimerin 2 0.82519
WRB tryptophan rich basic protein 0.823134
OARD1 O-acyl-ADP-ribose deacylase 1 0.82192
APOPT1 apoptogenic 1, mitochondrial 0.818753
NRP2 neuropilin 2 0.816443
LOC100128714 uncharacterized LOC100128714 0.803948
PTBP3 polypyrimidine tract binding protein 3 0.800256
PHF2 PHD finger protein 2 0.78442
FHIT fragile histidine triad 0.78287
IL1RAP interleukin 1 receptor accessory protein 0.779837
SCCPDH saccharopine dehydrogenase (putative) 0.777475
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.757675
MMP20 matrix metallopeptidase 20 0.757405
OR8A1 olfactory receptor, family 8, subfamily A, member 1 0.740032
KIAA1217 KIAA1217 0.736216
WSCD2 WSC domain containing 2 0.73075
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.729362
ELL elongation factor RNA polymerase II 0.702611
NRG1 neuregulin 1 0.684794
NUPL1 nucleoporin like 1 0.681837
FUT2 fucosyltransferase 2 (secretor status included) 0.674263
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 0.669544
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.660239
ALOX15 arachidonate 15-lipoxygenase 0.638472
TMEM51 transmembrane protein 51 0.629714
AQR aquarius intron-binding spliceosomal factor 0.628481
TMEM132C transmembrane protein 132C 0.62455
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.614416
TBX21 T-box 21 0.60781
JAKMIP1 janus kinase and microtubule interacting protein 1 0.594847
PSAT1 phosphoserine aminotransferase 1 0.591358
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.591358
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 0.590323
CPVL carboxypeptidase, vitellogenic-like 0.587807
ZNF608 zinc finger protein 608 0.585389
PRKCA protein kinase C, alpha 0.584682
PITRM1 pitrilysin metallopeptidase 1 0.581707
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.576144
ISM1 isthmin 1, angiogenesis inhibitor 0.572673