osteoarthritis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An arthritis that has_material_basis_in worn out cartilage located_in joint. (Human Disease Ontology, DOID_8398)
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Genes

706 genes co-occuring with the disease osteoarthritis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ACAN aggrecan 2.90508
MMP13 matrix metallopeptidase 13 2.74894
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 2.46059
MMP3 matrix metallopeptidase 3 2.42686
COMP cartilage oligomeric matrix protein 2.37886
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 2.31225
IL1B interleukin 1, beta 2.2706
MMP1 matrix metallopeptidase 1 2.16917
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.15509
COL2A1 collagen, type II, alpha 1 2.15406
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.05765
SOX9 SRY (sex determining region Y)-box 9 1.82595
GDF5 growth differentiation factor 5 1.79841
ASPN asporin 1.79165
TIMP1 TIMP metallopeptidase inhibitor 1 1.77044
TNF tumor necrosis factor 1.7546
CMC1 C-x(9)-C motif containing 1 1.72775
MATN3 matrilin 3 1.71043
COL10A1 collagen, type X, alpha 1 1.68136
TRIM47 tripartite motif containing 47 1.6791
FRZB frizzled-related protein 1.63411
PRG4 proteoglycan 4 1.58983
FMOD fibromodulin 1.57913
TGFB1 transforming growth factor, beta 1 1.56267
CRP C-reactive protein, pentraxin-related 1.55424
IL1A interleukin 1, alpha 1.52776
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 1.5093
IGF1 insulin-like growth factor 1 (somatomedin C) 1.49087
COL6A4P1 collagen, type VI, alpha 4 pseudogene 1 1.48779
IL6 interleukin 6 1.45572
MMP9 matrix metallopeptidase 9 1.44298
BMP2 bone morphogenetic protein 2 1.44035
COL9A1 collagen, type IX, alpha 1 1.43859
BGLAP bone gamma-carboxyglutamate (gla) protein 1.41183
IL1RN interleukin 1 receptor antagonist 1.41008
COL9A2 collagen, type IX, alpha 2 1.40351
MATN1 matrilin 1, cartilage matrix protein 1.38559
SP9 Sp9 transcription factor 1.37425
BGN biglycan 1.37207
RUNX2 runt-related transcription factor 2 1.35943
PTGES prostaglandin E synthase 1.35376
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.35071
LCTL lactase-like 1.34374
CTSK cathepsin K 1.3385
ALPL alkaline phosphatase, liver/bone/kidney 1.33021
ALPPL2 alkaline phosphatase, placental-like 2 1.31537
ALPP alkaline phosphatase, placental 1.31493
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 1.30794
MMP2 matrix metallopeptidase 2 1.30532
FN1 fibronectin 1 1.29571
ACRV1 acrosomal vesicle protein 1 1.29483
COL9A3 collagen, type IX, alpha 3 1.28086
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.27083
BMP7 bone morphogenetic protein 7 1.2582
CD68 CD68 molecule 1.25124
DDR2 discoidin domain receptor tyrosine kinase 2 1.24819
IHH indian hedgehog 1.2395
DCN decorin 1.2382
NOTCH1 notch 1 1.22779
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 1.20007
JUN jun proto-oncogene 1.19489
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 1.19186
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 1.18152
SMAD3 SMAD family member 3 1.17722
PHB2 prohibitin 2 1.16649
TAC1 tachykinin, precursor 1 1.1605
CALCA calcitonin-related polypeptide alpha 1.15283
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 1.13501
COG5 component of oligomeric golgi complex 5 1.13501
TIMP2 TIMP metallopeptidase inhibitor 2 1.12698
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.12572
LEP leptin 1.1253
CD44 CD44 molecule (Indian blood group) 1.12193
HAPLN1 hyaluronan and proteoglycan link protein 1 1.12024
CTSS cathepsin S 1.11351
FGF2 fibroblast growth factor 2 (basic) 1.09377
COL1A1 collagen, type I, alpha 1 1.08831
OSM oncostatin M 1.07866
IBSP integrin-binding sialoprotein 1.07866
COL11A1 collagen, type XI, alpha 1 1.0648
GPR22 G protein-coupled receptor 22 1.06396
COL11A2 collagen, type XI, alpha 2 1.06102
MRPL49 mitochondrial ribosomal protein L49 1.05807
CCL2 chemokine (C-C motif) ligand 2 1.05807
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 1.05765
BMP5 bone morphogenetic protein 5 1.05051
LAX1 lymphocyte transmembrane adaptor 1 1.04966
TRAPPC2 trafficking protein particle complex 2 1.04714
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 1.04672
SIK1 salt-inducible kinase 1 1.04462
IL17A interleukin 17A 1.02482
MMP14 matrix metallopeptidase 14 (membrane-inserted) 1.02271
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 1.01891
ACPP acid phosphatase, prostate 1.01807
NME8 NME/NM23 family member 8 1.01469
XYLT1 xylosyltransferase I 1.00499
CXCL8 chemokine (C-X-C motif) ligand 8 1.00288
MCF2L MCF.2 cell line derived transforming sequence-like 1.00035
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 0.997392
PLAU plasminogen activator, urokinase 0.979689
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.978426
TGFB3 transforming growth factor, beta 3 0.97086
SPP1 secreted phosphoprotein 1 0.963309
KRT86 keratin 86, type II 0.962472
MMP8 matrix metallopeptidase 8 0.944938
PTHLH parathyroid hormone-like hormone 0.942027
NGF nerve growth factor (beta polypeptide) 0.941196
CHI3L2 chitinase 3-like 2 0.932898
ADAM12 ADAM metallopeptidase domain 12 0.931656
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.923387
HAS1 hyaluronan synthase 1 0.918436
ALOX5 arachidonate 5-lipoxygenase 0.912668
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.904442
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.904032
NOS2 nitric oxide synthase 2, inducible 0.899514
DIO2 deiodinase, iodothyronine, type II 0.889258
MAPK8 mitogen-activated protein kinase 8 0.889258
LUM lumican 0.877376
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.875329
B3GAT3 beta-1,3-glucuronyltransferase 3 0.872053
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.870825
IL1R1 interleukin 1 receptor, type I 0.869596
SOX5 SRY (sex determining region Y)-box 5 0.863046
ANKH ANKH inorganic pyrophosphate transport regulator 0.862637
AMICA1 adhesion molecule, interacts with CXADR antigen 1 0.859362
SMAD2 SMAD family member 2 0.851583
PTH parathyroid hormone 0.851173
CTSB cathepsin B 0.850764
CXCL12 chemokine (C-X-C motif) ligand 12 0.849126
SOD2 superoxide dismutase 2, mitochondrial 0.848716
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.846259
IL18 interleukin 18 0.84585
ICAM1 intercellular adhesion molecule 1 0.84544
TIMP3 TIMP metallopeptidase inhibitor 3 0.822077
NPS neuropeptide S 0.821257
A1BG alpha-1-B glycoprotein 0.815514
CTGF connective tissue growth factor 0.815514
CD4 CD4 molecule 0.811411
SEBOX SEBOX homeobox 0.808539
HTRA1 HtrA serine peptidase 1 0.807718
PLA2G1B phospholipase A2, group IB (pancreas) 0.806898
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.804846
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.801564
MAPK14 mitogen-activated protein kinase 14 0.801154
IVD isovaleryl-CoA dehydrogenase 0.798692
TLR4 toll-like receptor 4 0.791311
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.788852
MARK3 MAP/microtubule affinity-regulating kinase 3 0.787623
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.787623
PLG plasminogen 0.786394
IL34 interleukin 34 0.785984
HAS2 hyaluronan synthase 2 0.785574
LOX lysyl oxidase 0.779023
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.776159
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.774523
BCAP29 B-cell receptor-associated protein 29 0.77207
ESR1 estrogen receptor 1 0.76921
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 0.763494
WNT16 wingless-type MMTV integration site family, member 16 0.760639
SDC4 syndecan 4 0.759008
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.757786
FOS FBJ murine osteosarcoma viral oncogene homolog 0.757786
HGD homogentisate 1,2-dioxygenase 0.755749
MSLNL mesothelin-like 0.754527
MATN4 matrilin 4 0.752898
NAMPT nicotinamide phosphoribosyltransferase 0.749237
TNC tenascin C 0.744766
COL1A2 collagen, type I, alpha 2 0.74436
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.743547
ANXA5 annexin A5 0.73746
SOST sclerostin 0.732191
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.72329
TGFB2 transforming growth factor, beta 2 0.722886
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.722482
CCL8 chemokine (C-C motif) ligand 8 0.71925
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.71925
RETN resistin 0.718846
VCAM1 vascular cell adhesion molecule 1 0.718443
MMP28 matrix metallopeptidase 28 0.718443
THY1 Thy-1 cell surface antigen 0.714005
TLR2 toll-like receptor 2 0.708364
IGFBP3 insulin-like growth factor binding protein 3 0.707559
MMP25 matrix metallopeptidase 25 0.707559
CCL3 chemokine (C-C motif) ligand 3 0.703536
FGF18 fibroblast growth factor 18 0.70233
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.700722
SOX6 SRY (sex determining region Y)-box 6 0.700321
ALB albumin 0.691094
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.690694
PDCD5 programmed cell death 5 0.689092
HMGB1 high mobility group box 1 0.678302
LRP5 low density lipoprotein receptor-related protein 5 0.676308
WISP1 WNT1 inducible signaling pathway protein 1 0.673518
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.667152
VCAN versican 0.666755
XYLT2 xylosyltransferase II 0.663975
KRT36 keratin 36, type I 0.663578
ESR2 estrogen receptor 2 (ER beta) 0.661197
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.659215
CXCL10 chemokine (C-X-C motif) ligand 10 0.656837
CHAD chondroadherin 0.655254
MCM8 minichromosome maintenance complex component 8 0.65288
MED12 mediator complex subunit 12 0.643009
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.642615
PADI4 peptidyl arginine deiminase, type IV 0.637889
IGFBP5 insulin-like growth factor binding protein 5 0.636315
BMP6 bone morphogenetic protein 6 0.632777
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 0.631991
SFRP1 secreted frizzled-related protein 1 0.631205
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.630813
AGER advanced glycosylation end product-specific receptor 0.626495
BCAN brevican 0.620617
CCL20 chemokine (C-C motif) ligand 20 0.617877
ZNF780B zinc finger protein 780B 0.612011
SCAF8 SR-related CTD-associated factor 8 0.612011
ZNF470 zinc finger protein 470 0.612011
SPP2 secreted phosphoprotein 2, 24kDa 0.612011
ZNF155 zinc finger protein 155 0.612011
CSNK1A1L casein kinase 1, alpha 1-like 0.612011
TLR3 toll-like receptor 3 0.608494
FGF1 fibroblast growth factor 1 (acidic) 0.608104
S100A8 S100 calcium binding protein A8 0.606543
IL10 interleukin 10 0.606543
MMP12 matrix metallopeptidase 12 0.59991
VIP vasoactive intestinal peptide 0.59991
KITLG KIT ligand 0.59952
PTGES2 prostaglandin E synthase 2 0.596792
PPARG peroxisome proliferator-activated receptor gamma 0.595623
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.592895
CCL5 chemokine (C-C motif) ligand 5 0.592116
S100A12 S100 calcium binding protein A12 0.591337
CXCL6 chemokine (C-X-C motif) ligand 6 0.587444
APOL3 apolipoprotein L, 3 0.587054
CTSD cathepsin D 0.587054
VEGFA vascular endothelial growth factor A 0.586665
IL4 interleukin 4 0.58433
AKAP8L A kinase (PRKA) anchor protein 8-like 0.58005
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.579661
CARD17 caspase recruitment domain family, member 17 0.579272
RPAIN RPA interacting protein 0.578494
KNG1 kininogen 1 0.577716
TSKU tsukushi, small leucine rich proteoglycan 0.571884
CLEC3B C-type lectin domain family 3, member B 0.570718
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.570329
MIA melanoma inhibitory activity 0.564889
MMP7 matrix metallopeptidase 7 0.561781
CXCL5 chemokine (C-X-C motif) ligand 5 0.561004
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 0.560227
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 0.559062
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.557509
HFE hemochromatosis 0.552463
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.551686
CLCF1 cardiotrophin-like cytokine factor 1 0.550911
MAPK3 mitogen-activated protein kinase 3 0.549747
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.546644
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.546256
CD79A CD79a molecule, immunoglobulin-associated alpha 0.545868
WNT3A wingless-type MMTV integration site family, member 3A 0.545093
SRY sex determining region Y 0.54393
ELANE elastase, neutrophil expressed 0.542379
HCST hematopoietic cell signal transducer 0.535796
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.535022
MIR146A microRNA 146a 0.533861
COL5A1 collagen, type V, alpha 1 0.533475
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.533475
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.533088
THBS1 thrombospondin 1 0.532314
CAT catalase 0.528063
LTF lactotransferrin 0.524202
SAAL1 serum amyloid A-like 1 0.523045
SP7 Sp7 transcription factor 0.523045
THUMPD1 THUMP domain containing 1 0.521888
BMP4 bone morphogenetic protein 4 0.520346
CALCR calcitonin receptor 0.51842
STAT1 signal transducer and activator of transcription 1, 91kDa 0.51534
DEAF1 DEAF1 transcription factor 0.511496
IL32 interleukin 32 0.510728
ADIPOR1 adiponectin receptor 1 0.510344
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.509576
PARD3B par-3 family cell polarity regulator beta 0.508041
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.508041
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.506507
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.505356
DOT1L DOT1-like histone H3K79 methyltransferase 0.50459
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.504207
IL15 interleukin 15 0.502292
COL3A1 collagen, type III, alpha 1 0.499614
PMFBP1 polyamine modulated factor 1 binding protein 1 0.496557
IL16 interleukin 16 0.496175
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.493885
CD163 CD163 molecule 0.49274
C1S complement component 1, s subcomponent 0.491215
PTN pleiotrophin 0.490454
HBA2 hemoglobin, alpha 2 0.490072
SIRT1 sirtuin 1 0.48893
CILP2 cartilage intermediate layer protein 2 0.487788
SOD1 superoxide dismutase 1, soluble 0.486646
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 0.485505
UNC93A unc-93 homolog A (C. elegans) 0.484744
POSTN periostin, osteoblast specific factor 0.483985
ADAMDEC1 ADAM-like, decysin 1 0.483224
LAMP3 lysosomal-associated membrane protein 3 0.478289
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.475255
VWF von Willebrand factor 0.475255
RHOB ras homolog family member B 0.472225
INS insulin 0.471846
CHPF chondroitin polymerizing factor 0.471089
CTSG cathepsin G 0.467684
TGFBR1 transforming growth factor, beta receptor 1 0.464283
FASLG Fas ligand (TNF superfamily, member 6) 0.462394
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.460883
DNTT DNA nucleotidylexotransferase 0.458241
COL27A1 collagen, type XXVII, alpha 1 0.457487
BSG basigin (Ok blood group) 0.456732
ADAM15 ADAM metallopeptidase domain 15 0.456355
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.455601
S100A11 S100 calcium binding protein A11 0.455224
POMC proopiomelanocortin 0.452208
HSPA4 heat shock 70kDa protein 4 0.451831
MAP2K3 mitogen-activated protein kinase kinase 3 0.449571
SELE selectin E 0.449194
PRELP proline/arginine-rich end leucine-rich repeat protein 0.448064
LPAR1 lysophosphatidic acid receptor 1 0.447687
IL2RA interleukin 2 receptor, alpha 0.445805
LEPR leptin receptor 0.4443
BAX BCL2-associated X protein 0.439786
MGP matrix Gla protein 0.439034
MRC2 mannose receptor, C type 2 0.435275
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.434899
CCR6 chemokine (C-C motif) receptor 6 0.434899
CMKLR1 chemerin chemokine-like receptor 1 0.434524
MMP17 matrix metallopeptidase 17 (membrane-inserted) 0.430017
PEPD peptidase D 0.430017
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.429642
PGRMC1 progesterone receptor membrane component 1 0.429642
LTBP2 latent transforming growth factor beta binding protein 2 0.428516
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.427765
GUSB glucuronidase, beta 0.427015
PTH1R parathyroid hormone 1 receptor 0.425514
OLAH oleoyl-ACP hydrolase 0.424014
TIMP4 TIMP metallopeptidase inhibitor 4 0.423265
UGDH UDP-glucose 6-dehydrogenase 0.42289
GDF10 growth differentiation factor 10 0.42289
C5AR1 complement component 5a receptor 1 0.42214
PRTG protogenin 0.421016
SOCS3 suppressor of cytokine signaling 3 0.420266
CP ceruloplasmin (ferroxidase) 0.419892
CD34 CD34 molecule 0.419892
APOL2 apolipoprotein L, 2 0.419892
HYAL1 hyaluronoglucosaminidase 1 0.419517
LAP3 leucine aminopeptidase 3 0.419517
TSPO translocator protein (18kDa) 0.419142
SENP6 SUMO1/sentrin specific peptidase 6 0.41465
SSC5D scavenger receptor cysteine rich family, 5 domains 0.413153
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.413153
NCOA1 nuclear receptor coactivator 1 0.413153
IL33 interleukin 33 0.412031
FZD5 frizzled class receptor 5 0.410535
CFI complement factor I 0.409787
ADIPOR2 adiponectin receptor 2 0.407545
LECT1 leukocyte cell derived chemotaxin 1 0.407172
CHSY1 chondroitin sulfate synthase 1 0.406425
CD38 CD38 molecule 0.405305
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.403811
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.403811
GPX5 glutathione peroxidase 5 0.403064
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.400826
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.399707
GPX4 glutathione peroxidase 4 0.399707
IRAK3 interleukin-1 receptor-associated kinase 3 0.397471
COL15A1 collagen, type XV, alpha 1 0.397098
CYTL1 cytokine-like 1 0.392629
GLB1 galactosidase, beta 1 0.392257
CXCR2 chemokine (C-X-C motif) receptor 2 0.391141
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.390397
HMGB2 high mobility group box 2 0.388538
IL2 interleukin 2 0.387051
FTH1 ferritin, heavy polypeptide 1 0.386308
GPX1 glutathione peroxidase 1 0.384822
CXCL3 chemokine (C-X-C motif) ligand 3 0.384822
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.382594
INHBA inhibin, beta A 0.382594
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.381852
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 0.381852
TP53 tumor protein p53 0.381852
MOAP1 modulator of apoptosis 1 0.377402
CHRD chordin 0.377402
JAM3 junctional adhesion molecule 3 0.373698
ATF3 activating transcription factor 3 0.370368
C1R complement component 1, r subcomponent 0.367779
GPC4 glypican 4 0.366671
THBS3 thrombospondin 3 0.365932
FTL ferritin, light polypeptide 0.365193
CXCL2 chemokine (C-X-C motif) ligand 2 0.364454
S100A9 S100 calcium binding protein A9 0.362978
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.360764
MPO myeloperoxidase 0.360764
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.359657
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.359289
HBP1 HMG-box transcription factor 1 0.356709
MMP10 matrix metallopeptidase 10 0.353763
LOC102724852 uncharacterized LOC102724852 0.353763
ANGPTL4 angiopoietin-like 4 0.353395
S100A4 S100 calcium binding protein A4 0.353395
DLK2 delta-like 2 homolog (Drosophila) 0.351555
ACTG1 actin gamma 1 0.35082
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.348614
MRAP melanocortin 2 receptor accessory protein 0.347511
FGF7 fibroblast growth factor 7 0.347511
TGM2 transglutaminase 2 0.346777
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.346409
KANK4 KN motif and ankyrin repeat domains 4 0.344941
HBA1 hemoglobin, alpha 1 0.344574
RGS10 regulator of G-protein signaling 10 0.342372
ACTB actin, beta 0.340906
CXCR3 chemokine (C-X-C motif) receptor 3 0.33944
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.338707
HPR haptoglobin-related protein 0.33651
OLIG3 oligodendrocyte transcription factor 3 0.335046
FZD2 frizzled class receptor 2 0.334681
B2M beta-2-microglobulin 0.334681
PPA1 pyrophosphatase (inorganic) 1 0.332121
ACE angiotensin I converting enzyme 0.332121
PDGFB platelet-derived growth factor beta polypeptide 0.331025
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.33066
LTBP3 latent transforming growth factor beta binding protein 3 0.330295
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.32993
CRCP CGRP receptor component 0.329565
UXS1 UDP-glucuronate decarboxylase 1 0.3292
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.328834
WNT8A wingless-type MMTV integration site family, member 8A 0.32774
IL23A interleukin 23, alpha subunit p19 0.326646
NCR3 natural cytotoxicity triggering receptor 3 0.326281
CXCR1 chemokine (C-X-C motif) receptor 1 0.326281
TLR1 toll-like receptor 1 0.324823
CFP complement factor properdin 0.323002
TF transferrin 0.322273
IGF1R insulin-like growth factor 1 receptor 0.322273
TTR transthyretin 0.322273
WNT7B wingless-type MMTV integration site family, member 7B 0.321545
CREM cAMP responsive element modulator 0.320454
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.32009
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.318272
HIP1R huntingtin interacting protein 1 related 0.317545
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.317182
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.317182
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.315729
BMPR1A bone morphogenetic protein receptor, type IA 0.31464
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.313915
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.313189
NOG noggin 0.312102
GPC2 glypican 2 0.311014
WDFY3 WD repeat and FYVE domain containing 3 0.309566
PCNA proliferating cell nuclear antigen 0.309204
HP haptoglobin 0.308118
TMEM163 transmembrane protein 163 0.307757
ADGRE5 adhesion G protein-coupled receptor E5 0.305587
VIPR1 vasoactive intestinal peptide receptor 1 0.305587
CCL3L1 chemokine (C-C motif) ligand 3-like 1 0.304503
CFL1 cofilin 1 (non-muscle) 0.304142
ITGA10 integrin, alpha 10 0.30342
AQP1 aquaporin 1 (Colton blood group) 0.302337
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.302337
FAM195A family with sequence similarity 195, member A 0.301615
HYAL2 hyaluronoglucosaminidase 2 0.299452
KLHL42 kelch-like family member 42 0.299092
DVL2 dishevelled segment polarity protein 2 0.298371
PADI2 peptidyl arginine deiminase, type II 0.298011
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.297291
MIR223 microRNA 223 0.296571
PARP1 poly (ADP-ribose) polymerase 1 0.296571
EPAS1 endothelial PAS domain protein 1 0.295132
BTNL2 butyrophilin-like 2 0.295132
SAA1 serum amyloid A1 0.291898
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.291539
MRI1 methylthioribose-1-phosphate isomerase 1 0.290462
GADD45B growth arrest and DNA-damage-inducible, beta 0.290462
SNX9 sorting nexin 9 0.289386
EGFL8 EGF-like-domain, multiple 8 0.289027
KIN Kin17 DNA and RNA binding protein 0.28616
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.284728
CASC3 cancer susceptibility candidate 3 0.284371
FILIP1 filamin A interacting protein 1 0.284013
COL16A1 collagen, type XVI, alpha 1 0.283297
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 0.28151
UFL1 UFM1-specific ligase 1 0.28151
IL22 interleukin 22 0.280796
OPTC opticin 0.280439
CD5L CD5 molecule-like 0.279367
HMOX1 heme oxygenase 1 0.279011
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.277584
IL7 interleukin 7 0.276158
TARS threonyl-tRNA synthetase 0.274732
CCL21 chemokine (C-C motif) ligand 21 0.272597
IRF1 interferon regulatory factor 1 0.272241
LYZ lysozyme 0.270819
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.269043
WDR20 WD repeat domain 20 0.268687
F3 coagulation factor III (thromboplastin, tissue factor) 0.268332
CXCL9 chemokine (C-X-C motif) ligand 9 0.267977
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.266913
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.266913
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.266558
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.266558
AHSG alpha-2-HS-glycoprotein 0.265494
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.264431
LECT2 leukocyte cell-derived chemotaxin 2 0.263722
SULF1 sulfatase 1 0.263368
EBF4 early B-cell factor 4 0.263014
ACSM3 acyl-CoA synthetase medium-chain family member 3 0.26266
IL1RL2 interleukin 1 receptor-like 2 0.261599
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.261599
CCL13 chemokine (C-C motif) ligand 13 0.260538
GLRA3 glycine receptor, alpha 3 0.260184
PER2 period circadian clock 2 0.258417
SFRP4 secreted frizzled-related protein 4 0.256652
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 0.256652
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.255594
OPRM1 opioid receptor, mu 1 0.254536
FICD FIC domain containing 0.252422
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing 0.249608
ULK1 unc-51 like autophagy activating kinase 1 0.248203
CCL4 chemokine (C-C motif) ligand 4 0.24715
EPHB4 EPH receptor B4 0.24715
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.24715
MAB21L2 mab-21-like 2 (C. elegans) 0.246799
PLS1 plastin 1 0.246799
TADA1 transcriptional adaptor 1 0.246098
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.243995
LHX2 LIM homeobox 2 0.243295
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.242245
WNT1 wingless-type MMTV integration site family, member 1 0.242245
GREM2 gremlin 2, DAN family BMP antagonist 0.23945
DSG4 desmoglein 4 0.239101
PCOLCE2 procollagen C-endopeptidase enhancer 2 0.238403
TBL1X transducin (beta)-like 1X-linked 0.237357
MYD88 myeloid differentiation primary response 88 0.23666
ADAM17 ADAM metallopeptidase domain 17 0.23666
SPON1 spondin 1, extracellular matrix protein 0.236312
CPA6 carboxypeptidase A6 0.235964
ICAM2 intercellular adhesion molecule 2 0.235964
ACP5 acid phosphatase 5, tartrate resistant 0.235268
SDC2 syndecan 2 0.23492
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.233878
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.23353
F8 coagulation factor VIII, procoagulant component 0.232836
MTL5 metallothionein-like 5, testis-specific (tesmin) 0.232836
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.232836
CTSL cathepsin L 0.232142
TSPAN9 tetraspanin 9 0.231795
LEF1 lymphoid enhancer-binding factor 1 0.230755
DEFB4A defensin, beta 4A 0.230755
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.229716
MGARP mitochondria-localized glutamic acid-rich protein 0.228679
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.226952
EGR1 early growth response 1 0.226952
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.223509
DDN dendrin 0.223165
GREM1 gremlin 1, DAN family BMP antagonist 0.223165
MKX mohawk homeobox 0.222822
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.222822
EFNB2 ephrin-B2 0.222822
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.221793
DEFB103A defensin, beta 103A 0.221108
MIPOL1 mirror-image polydactyly 1 0.220766
USP33 ubiquitin specific peptidase 33 0.220766
OGN osteoglycin 0.219398
C7ORF49 chromosome 7 open reading frame 49 0.219398
TWF1 twinfilin actin binding protein 1 0.219057
SDC3 syndecan 3 0.218374
SMAD7 SMAD family member 7 0.218374
SEPT2 septin 2 0.218034
TNXB tenascin XB 0.217352
ANKLE2 ankyrin repeat and LEM domain containing 2 0.216672
E2F2 E2F transcription factor 2 0.216332
ARHGAP44 Rho GTPase activating protein 44 0.215314
NPY neuropeptide Y 0.214975
MXRA5 matrix-remodelling associated 5 0.214636
AMIGO2 adhesion molecule with Ig-like domain 2 0.214636
IRAK1 interleukin-1 receptor-associated kinase 1 0.214297
CRLF1 cytokine receptor-like factor 1 0.213621
HPX hemopexin 0.213283
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.211934
AP3D1 adaptor-related protein complex 3, delta 1 subunit 0.211597
TNXA tenascin XA (pseudogene) 0.210925
CD86 CD86 molecule 0.209248
SST somatostatin 0.208914
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.207912
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.206913
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.20658
PER1 period circadian clock 1 0.20658
ACP1 acid phosphatase 1, soluble 0.205916
DDIT3 DNA-damage-inducible transcript 3 0.205585
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 0.204593
LTA lymphotoxin alpha 0.203604
ATF2 activating transcription factor 2 0.203275
PZP pregnancy-zone protein 0.203275
DEFB103B defensin, beta 103B 0.201635
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.200982
XBP1 X-box binding protein 1 0.200982
ANXA2 annexin A2 0.200656
CRTAC1 cartilage acidic protein 1 0.200656
ADAM23 ADAM metallopeptidase domain 23 0.200331
PRKCH protein kinase C, eta 0.198709
SCARB1 scavenger receptor class B, member 1 0.198386
IFI44 interferon-induced protein 44 0.198386
SCARB2 scavenger receptor class B, member 2 0.196779
TBL1Y transducin (beta)-like 1, Y-linked 0.196779
CS citrate synthase 0.196139
OSCAR osteoclast associated, immunoglobulin-like receptor 0.196139
FST follistatin 0.196139
SAA4 serum amyloid A4, constitutive 0.194865
WNT5A wingless-type MMTV integration site family, member 5A 0.193915
PPARA peroxisome proliferator-activated receptor alpha 0.1936
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.193285
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.192971
MVD mevalonate (diphospho) decarboxylase 0.192657
POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.192657
IL18BP interleukin 18 binding protein 0.192031
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 0.191719
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.189859
BCL9 B-cell CLL/lymphoma 9 0.188326
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.188326
NCOR2 nuclear receptor corepressor 2 0.188326
FAAH fatty acid amide hydrolase 0.187415
JAK2 Janus kinase 2 0.187113
DIO3 deiodinase, iodothyronine, type III 0.186811
KIF12 kinesin family member 12 0.18591
SYK spleen tyrosine kinase 0.18591
EHF ets homologous factor 0.185016
IL7R interleukin 7 receptor 0.185016
SQSTM1 sequestosome 1 0.185016
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.185016
ERV3-1 endogenous retrovirus group 3, member 1 0.185016
AQP3 aquaporin 3 (Gill blood group) 0.18472
CD36 CD36 molecule (thrombospondin receptor) 0.184128
NLRP3 NLR family, pyrin domain containing 3 0.183835
MYBPH myosin binding protein H 0.183248
GPNMB glycoprotein (transmembrane) nmb 0.182957
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.182957
PRDX5 peroxiredoxin 5 0.182957
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.181798
PDYN prodynorphin 0.18151
WNT5B wingless-type MMTV integration site family, member 5B 0.181222
TXN thioredoxin 0.181222
GDF7 growth differentiation factor 7 0.181222
NID2 nidogen 2 (osteonidogen) 0.181222
LGALS3 lectin, galactoside-binding, soluble, 3 0.180652
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 0.180652
CNN3 calponin 3, acidic 0.180367
OMD osteomodulin 0.179239
ICAM3 intercellular adhesion molecule 3 0.178126
KAT5 K(lysine) acetyltransferase 5 0.177851
TWIST1 twist family bHLH transcription factor 1 0.177301
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.176215
CHID1 chitinase domain containing 1 0.175679
NT5E 5'-nucleotidase, ecto (CD73) 0.175679
SRCAP Snf2-related CREBBP activator protein 0.175411
NGFR nerve growth factor receptor 0.174093
CXCL16 chemokine (C-X-C motif) ligand 16 0.173832
CCDC85B coiled-coil domain containing 85B 0.173832
ITGA6 integrin, alpha 6 0.173571
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.173571
ETV4 ets variant 4 0.173571
BECN1 beclin 1, autophagy related 0.173057
TYROBP TYRO protein tyrosine kinase binding protein 0.172799
FSTL1 follistatin-like 1 0.172799
CRHR2 corticotropin releasing hormone receptor 2 0.172291
BMP2K BMP2 inducible kinase 0.172038
AXIN2 axin 2 0.171535
CD53 CD53 molecule 0.171286
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.170789
CST3 cystatin C 0.170544
MATK megakaryocyte-associated tyrosine kinase 0.170054
CXCL13 chemokine (C-X-C motif) ligand 13 0.16933
CFDP1 craniofacial development protein 1 0.168617
MYDGF myeloid-derived growth factor 0.167452
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.167452
CD69 CD69 molecule 0.167224
S100A10 S100 calcium binding protein A10 0.166995
EEF1A1P6 eukaryotic translation elongation factor 1 alpha 1 pseudogene 6 0.166544
C6ORF25 chromosome 6 open reading frame 25 0.166095
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.166095
EFHD1 EF-hand domain family, member D1 0.165217
VASN vasorin 0.163938
FLT1 fms-related tyrosine kinase 1 0.163729
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.163729
MCAM melanoma cell adhesion molecule 0.163729
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.162306
CCL19 chemokine (C-C motif) ligand 19 0.161716
MARK2 MAP/microtubule affinity-regulating kinase 2 0.161331
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.160761
ITM2A integral membrane protein 2A 0.160387
HYLS1 hydrolethalus syndrome 1 0.160387
PRRC2A proline-rich coiled-coil 2A 0.160203
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.159838
DPP4 dipeptidyl-peptidase 4 0.15948
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.158778
PTH2R parathyroid hormone 2 receptor 0.158778
MGST1 microsomal glutathione S-transferase 1 0.158605
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.158266
CANT1 calcium activated nucleotidase 1 0.158266
ANXA1 annexin A1 0.158097
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.158097
AZU1 azurocidin 1 0.157929
DOK4 docking protein 4 0.157929