orphenadrine-4537 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the orphenadrine-4537 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BBC3 BCL2 binding component 3
BIRC3 baculoviral IAP repeat containing 3
BZRAP1 benzodiazepine receptor (peripheral) associated protein 1
C1ORF116 chromosome 1 open reading frame 116
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CEND1 cell cycle exit and neuronal differentiation 1
CHKA choline kinase alpha
CISH cytokine inducible SH2-containing protein
CLTCL1 clathrin, heavy chain-like 1
COL14A1 collagen, type XIV, alpha 1
CTAG2 cancer/testis antigen 2
CTNND2 catenin (cadherin-associated protein), delta 2
CTNS cystinosin, lysosomal cystine transporter
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDO D-aspartate oxidase
DENND3 DENN/MADD domain containing 3
DGKD diacylglycerol kinase, delta 130kDa
DUOX2 dual oxidase 2
ETV6 ets variant 6
FBXO31 F-box protein 31
FGF1 fibroblast growth factor 1 (acidic)
FGF5 fibroblast growth factor 5
FYB FYN binding protein
GHRHR growth hormone releasing hormone receptor
GK glycerol kinase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPSM3 G-protein signaling modulator 3
GREB1L growth regulation by estrogen in breast cancer-like
GSK3A glycogen synthase kinase 3 alpha
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHAT hedgehog acyltransferase
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICOSLG inducible T-cell co-stimulator ligand
IRF5 interferon regulatory factor 5
ITGA8 integrin, alpha 8
KHSRP KH-type splicing regulatory protein
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KRT34 keratin 34, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LYRM9 LYR motif containing 9
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MBL2 mannose-binding lectin (protein C) 2, soluble
MKL1 megakaryoblastic leukemia (translocation) 1
MRPL41 mitochondrial ribosomal protein L41
MXD4 MAX dimerization protein 4
MYL10 myosin, light chain 10, regulatory
NAV3 neuron navigator 3
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEUROD1 neuronal differentiation 1
OR2H2 olfactory receptor, family 2, subfamily H, member 2
ORC5 origin recognition complex, subunit 5
PAX4 paired box 4
PCDHA5 protocadherin alpha 5
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEAK1 pseudopodium-enriched atypical kinase 1
PENK proenkephalin
PPARA peroxisome proliferator-activated receptor alpha
PRKCE protein kinase C, epsilon
PRPF18 pre-mRNA processing factor 18
PRPH peripherin
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTPRR protein tyrosine phosphatase, receptor type, R
RAP1GAP RAP1 GTPase activating protein
RB1 retinoblastoma 1
REPS1 RALBP1 associated Eps domain containing 1
RHCE Rh blood group, CcEe antigens
RUNX1 runt-related transcription factor 1
SAMD4A sterile alpha motif domain containing 4A
SEC24A SEC24 family member A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGLEC6 sialic acid binding Ig-like lectin 6
SLN sarcolipin
SOX15 SRY (sex determining region Y)-box 15
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF5 serine/arginine-rich splicing factor 5
SRSF7 serine/arginine-rich splicing factor 7
ST18 suppression of tumorigenicity 18, zinc finger
STK24 serine/threonine kinase 24
TAT tyrosine aminotransferase
TGFB2 transforming growth factor, beta 2
TLN2 talin 2
TRAF3IP3 TRAF3 interacting protein 3
WDR1 WD repeat domain 1
WNT16 wingless-type MMTV integration site family, member 16
ZHX3 zinc fingers and homeoboxes 3
ZNF234 zinc finger protein 234
ZNF639 zinc finger protein 639
ZNF778 zinc finger protein 778
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ADAM2 ADAM metallopeptidase domain 2
AKAP5 A kinase (PRKA) anchor protein 5
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANP32A-IT1 ANP32A intronic transcript 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAAT bile acid CoA:amino acid N-acyltransferase
C1QTNF1 C1q and tumor necrosis factor related protein 1
C3 complement component 3
CA11 carbonic anhydrase XI
CCNJ cyclin J
CCP110 centriolar coiled coil protein 110kDa
CD101 CD101 molecule
CD68 CD68 molecule
CEP112 centrosomal protein 112kDa
CES3 carboxylesterase 3
CIR1 corepressor interacting with RBPJ, 1
COL9A2 collagen, type IX, alpha 2
CPNE7 copine VII
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DBR1 debranching RNA lariats 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DUSP8 dual specificity phosphatase 8
FAM184A family with sequence similarity 184, member A
FAM222B family with sequence similarity 222, member B
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLRT3 fibronectin leucine rich transmembrane protein 3
FMO4 flavin containing monooxygenase 4
GAS8 growth arrest-specific 8
GRTP1 growth hormone regulated TBC protein 1
HAS2 hyaluronan synthase 2
HIST1H2AJ histone cluster 1, H2aj
HIST1H2AM histone cluster 1, H2am
HIST1H2BO histone cluster 1, H2bo
HIST1H4D histone cluster 1, H4d
HOMER2 homer scaffolding protein 2
HOXA7 homeobox A7
HOXC13 homeobox C13
IREB2 iron-responsive element binding protein 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD15 potassium channel tetramerization domain containing 15
LOC257152 uncharacterized LOC257152
LOC390998 ribosomal protein L10 pseudogene
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRK1 leucine-rich repeat kinase 1
MCC mutated in colorectal cancers
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGP matrix Gla protein
MKS1 Meckel syndrome, type 1
MTHFSD methenyltetrahydrofolate synthetase domain containing
NDP Norrie disease (pseudoglioma)
NDRG4 NDRG family member 4
NKX3-2 NK3 homeobox 2
NSUN3 NOP2/Sun domain family, member 3
PALM paralemmin
PALMD palmdelphin
PCOLCE procollagen C-endopeptidase enhancer
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PHKG2 phosphorylase kinase, gamma 2 (testis)
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLH polymerase (DNA directed), eta
PORCN porcupine homolog (Drosophila)
PRB3 proline-rich protein BstNI subfamily 3
PRR15L proline rich 15-like
PTK6 protein tyrosine kinase 6
RAB36 RAB36, member RAS oncogene family
RAI2 retinoic acid induced 2
RNF122 ring finger protein 122
RPS17P5 ribosomal protein S17 pseudogene 5
SAMD9 sterile alpha motif domain containing 9
SATB1 SATB homeobox 1
SAYSD1 SAYSVFN motif domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SCIN scinderin
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPP1 selenoprotein P, plasma, 1
SH2D2A SH2 domain containing 2A
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC22A18 solute carrier family 22, member 18
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRBD1 S1 RNA binding domain 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TENM1 teneurin transmembrane protein 1
TENM4 teneurin transmembrane protein 4
TGIF1 TGFB-induced factor homeobox 1
TMEM19 transmembrane protein 19
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TOM1 target of myb1 (chicken)
TRIM25 tripartite motif containing 25
TRIM9 tripartite motif containing 9
TUBA3C tubulin, alpha 3c
UBTD1 ubiquitin domain containing 1
ZFP30 ZFP30 zinc finger protein
ZNF253 zinc finger protein 253
ZNF552 zinc finger protein 552