optic lobe Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Either of two prominences of the midbrain concerned with vision. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000965)
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Genes

381 proteins co-occuring with the tissue optic lobe in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
TECTA tectorin alpha 2.60426
EFNA2 ephrin-A2 2.00332
SEMG1 semenogelin I 1.95303
CHAT choline O-acetyltransferase 1.90966
ACHE acetylcholinesterase (Yt blood group) 1.80666
CALB1 calbindin 1, 28kDa 1.60663
PVALB parvalbumin 1.58584
TIMELESS timeless circadian clock 1.58043
BDNF brain-derived neurotrophic factor 1.53047
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 1.45193
EPHA3 EPH receptor A3 1.43848
POU4F1 POU class 4 homeobox 1 1.39697
TAC1 tachykinin, precursor 1 1.37408
NPY neuropeptide Y 1.36951
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.36359
EN2 engrailed homeobox 2 1.35449
FOS FBJ murine osteosarcoma viral oncogene homolog 1.34587
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.31198
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.27381
NTF4 neurotrophin 4 1.2595
CALB2 calbindin 2 1.25637
EFNA5 ephrin-A5 1.25012
DTNA dystrobrevin, alpha 1.24788
NPS neuropeptide S 1.2345
EPHA8 EPH receptor A8 1.21001
EFNB1 ephrin-B1 1.19978
TH tyrosine hydroxylase 1.1554
DSC3 desmocollin 3 1.14254
PAX7 paired box 7 1.13723
ISL2 ISL LIM homeobox 2 1.12394
OPN4 opsin 4 1.1204
POU4F2 POU class 4 homeobox 2 1.10889
EPHB3 EPH receptor B3 1.10004
PORCN porcupine homolog (Drosophila) 1.08811
FGF8 fibroblast growth factor 8 (androgen-induced) 1.03083
PAX6 paired box 6 1.01243
EN1 engrailed homeobox 1 0.984991
EPHB2 EPH receptor B2 0.978917
CDH7 cadherin 7, type 2 0.968955
NGF nerve growth factor (beta polypeptide) 0.968523
PAX2 paired box 2 0.955565
SST somatostatin 0.942645
GBX2 gastrulation brain homeobox 2 0.939206
CDH19 cadherin 19, type 2 0.931051
VAX2 ventral anterior homeobox 2 0.926336
OTX2 orthodenticle homeobox 2 0.925051
EPHA5 EPH receptor A5 0.905831
SGPL1 sphingosine-1-phosphate lyase 1 0.904978
GFAP glial fibrillary acidic protein 0.901573
OLFM2 olfactomedin 2 0.89732
EPHB1 EPH receptor B1 0.89562
BSX brain-specific homeobox 0.890525
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.88671
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.884167
PCDH19 protocadherin 19 0.884167
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.880781
LGALS4 lectin, galactoside-binding, soluble, 4 0.874439
GDF5 growth differentiation factor 5 0.868107
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.848745
CNTF ciliary neurotrophic factor 0.833642
GRM8 glutamate receptor, metabotropic 8 0.832385
ADA adenosine deaminase 0.831966
CDH8 cadherin 8, type 2 0.816486
OTUD4 OTU deubiquitinase 4 0.813144
OTUD4P1 OTUD4 pseudogene 1 0.813144
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.812309
SCGN secretagogin, EF-hand calcium binding protein 0.811056
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.804378
HCRT hypocretin (orexin) neuropeptide precursor 0.802293
ADCY1 adenylate cyclase 1 (brain) 0.796874
SOX14 SRY (sex determining region Y)-box 14 0.796041
BCHE butyrylcholinesterase 0.770685
EPHA4 EPH receptor A4 0.766954
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.766125
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.761984
TLE4 transducin-like enhancer of split 4 0.76157
OLFM1 olfactomedin 1 0.76157
CRH corticotropin releasing hormone 0.749992
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.749579
GRM2 glutamate receptor, metabotropic 2 0.74834
GNRH2 gonadotropin-releasing hormone 2 0.745864
MYRF myelin regulatory factor 0.745451
CAPN7 calpain 7 0.738854
EPHA7 EPH receptor A7 0.737206
GLUL glutamate-ammonia ligase 0.735971
GAL galanin/GMAP prepropeptide 0.729797
RICTOR RPTOR independent companion of MTOR, complex 2 0.729385
MAP2 microtubule-associated protein 2 0.725685
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.722809
ABAT 4-aminobutyrate aminotransferase 0.70968
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.70968
PCDH11Y protocadherin 11 Y-linked 0.70845
CCK cholecystokinin 0.703945
CLOCK clock circadian regulator 0.700671
PENK proenkephalin 0.699035
RXFP4 relaxin/insulin-like family peptide receptor 4 0.698216
PTH2 parathyroid hormone 2 0.696581
SDF4 stromal cell derived factor 4 0.696172
PCDH11X protocadherin 11 X-linked 0.694537
NOTCH1 notch 1 0.683103
EFNB2 ephrin-B2 0.675765
MAP1B microtubule-associated protein 1B 0.67495
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.672506
FOXN4 forkhead box N4 0.669657
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.669657
RYK receptor-like tyrosine kinase 0.669657
SOX21 SRY (sex determining region Y)-box 21 0.667622
RNF216 ring finger protein 216 0.660304
PTDSS2 phosphatidylserine synthase 2 0.659085
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.657054
NGFR nerve growth factor receptor 0.652994
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.649749
RHO rhodopsin 0.648938
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.640023
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.639619
DES desmin 0.638404
BOD1 biorientation of chromosomes in cell division 1 0.633144
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 0.632335
POU4F3 POU class 4 homeobox 3 0.627889
GRM7 glutamate receptor, metabotropic 7 0.625061
PLXNA3 plexin A3 0.6182
OPRM1 opioid receptor, mu 1 0.6182
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.607319
GSX1 GS homeobox 1 0.604904
BRD2 bromodomain containing 2 0.60249
PLXNA2 plexin A2 0.600479
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.593649
SIX3 SIX homeobox 3 0.593649
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.593247
AKAP5 A kinase (PRKA) anchor protein 5 0.592043
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.59124
NMB neuromedin B 0.580017
GRM4 glutamate receptor, metabotropic 4 0.575216
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 0.568823
NTS neurotensin 0.568823
NTF3 neurotrophin 3 0.568025
CARTPT CART prepropeptide 0.563238
NTN1 netrin 1 0.56005
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.558856
POMC proopiomelanocortin 0.55607
MNX1 motor neuron and pancreas homeobox 1 0.555274
ADORA1 adenosine A1 receptor 0.551695
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.551695
PLXNA4 plexin A4 0.551695
KSR2 kinase suppressor of ras 2 0.551298
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.548517
EMX1 empty spiracles homeobox 1 0.54812
RELN reelin 0.540585
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.540188
GRP gastrin-releasing peptide 0.534647
TRNAU1AP tRNA selenocysteine 1 associated protein 1 0.53346
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.530693
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.530298
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 0.527534
DRAXIN dorsal inhibitory axon guidance protein 0.522011
MAPT microtubule-associated protein tau 0.521223
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.520041
NXPH1 neurexophilin 1 0.520041
TRH thyrotropin-releasing hormone 0.519647
PISD phosphatidylserine decarboxylase 0.514924
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.51453
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.510992
TNR tenascin R 0.510599
PDYN prodynorphin 0.510206
PTDSS1 phosphatidylserine synthase 1 0.507849
L1CAM L1 cell adhesion molecule 0.505102
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.503926
RXFP3 relaxin/insulin-like family peptide receptor 3 0.503141
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.50275
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.499615
FJX1 four jointed box 1 (Drosophila) 0.499615
CRYGD crystallin, gamma D 0.498832
TRHDE thyrotropin-releasing hormone degrading enzyme 0.497657
SHH sonic hedgehog 0.496874
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.494918
LHX9 LIM homeobox 9 0.492182
PNPLA6 patatin-like phospholipase domain containing 6 0.4914
CAPN15 calpain 15 0.491009
PTCH1 patched 1 0.485935
BRI3 brain protein I3 0.485156
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.485156
GATA2 GATA binding protein 2 0.483986
TTC8 tetratricopeptide repeat domain 8 0.482817
DPF1 D4, zinc and double PHD fingers family 1 0.481648
OXTR oxytocin receptor 0.478923
SMAD5-AS1 SMAD5 antisense RNA 1 0.477756
CALCB calcitonin-related polypeptide beta 0.475034
MAP4 microtubule-associated protein 4 0.471151
WARS tryptophanyl-tRNA synthetase 0.469211
CALCA calcitonin-related polypeptide alpha 0.465723
RNF139 ring finger protein 139 0.463787
PAX3 paired box 3 0.463013
ANAPC5 anaphase promoting complex subunit 5 0.461465
NEFM neurofilament, medium polypeptide 0.460692
EI24 etoposide induced 2.4 0.460692
SYN1 synapsin I 0.459918
ADCY8 adenylate cyclase 8 (brain) 0.459145
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 0.457214
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.456055
CNIH2 cornichon family AMPA receptor auxiliary protein 2 0.454512
GDNF glial cell derived neurotrophic factor 0.45374
GALP galanin-like peptide 0.453355
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 0.447961
ZIC5 Zic family member 5 0.444884
CLSTN1 calsyntenin 1 0.439507
ESRRB estrogen-related receptor beta 0.438356
TXNL4B thioredoxin-like 4B 0.434523
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.428018
ATOH7 atonal homolog 7 (Drosophila) 0.426872
HMX3 H6 family homeobox 3 0.423818
COX17 COX17 cytochrome c oxidase copper chaperone 0.422292
AVPR1A arginine vasopressin receptor 1A 0.419242
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 0.412011
VIP vasoactive intestinal peptide 0.41087
MED12 mediator complex subunit 12 0.408972
CLDN11 claudin 11 0.408972
METRN meteorin, glial cell differentiation regulator 0.408212
DST dystonin 0.407453
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.407073
KLF9 Kruppel-like factor 9 0.402523
CORT cortistatin 0.402523
MYO5A myosin VA (heavy chain 12, myoxin) 0.398357
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.395709
PLXNA1 plexin A1 0.393064
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.388535
NUMB numb homolog (Drosophila) 0.388158
MCHR2 melanin-concentrating hormone receptor 2 0.387404
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.385143
RGMB repulsive guidance molecule family member b 0.382131
TACR3 tachykinin receptor 3 0.381003
PGM3 phosphoglucomutase 3 0.380251
NTNG2 netrin G2 0.379499
LRRN1 leucine rich repeat neuronal 1 0.378372
TUBA1A tubulin, alpha 1a 0.376494
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.374618
RGMA repulsive guidance molecule family member a 0.374243
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.373493
NIN ninein (GSK3B interacting protein) 0.372743
RLN3 relaxin 3 0.371619
THY1 Thy-1 cell surface antigen 0.37087
NCKAP1 NCK-associated protein 1 0.369373
NOP56 NOP56 ribonucleoprotein 0.36825
IPP intracisternal A particle-promoted polypeptide 0.367129
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.365633
NFASC neurofascin 0.364886
CRABP1 cellular retinoic acid binding protein 1 0.364886
RCVRN recoverin 0.36302
QRFP pyroglutamylated RFamide peptide 0.361527
BARHL1 BarH-like homeobox 1 0.361155
NENF neudesin neurotrophic factor 0.360409
ZIC4 Zic family member 4 0.359664
TSN translin 0.359292
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.358174
GRM1 glutamate receptor, metabotropic 1 0.35743
HM13 histocompatibility (minor) 13 0.355942
ELF2 E74-like factor 2 (ets domain transcription factor) 0.355198
PITX2 paired-like homeodomain 2 0.352598
HES5 hes family bHLH transcription factor 5 0.352598
UBN1 ubinuclein 1 0.351856
SLC35E2B solute carrier family 35, member E2B 0.351114
DBNL drebrin-like 0.351114
EGR1 early growth response 1 0.350743
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.350743
GRM5 glutamate receptor, metabotropic 5 0.348148
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.344449
TPH1 tryptophan hydroxylase 1 0.34334
AIF1 allograft inflammatory factor 1 0.34334
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.342971
IGLL5 immunoglobulin lambda-like polypeptide 5 0.340388
SNAP23 synaptosomal-associated protein, 23kDa 0.338177
RBPMS RNA binding protein with multiple splicing 0.337808
GLDN gliomedin 0.3356
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.333763
CA1 carbonic anhydrase I 0.33156
EMP3 epithelial membrane protein 3 0.330827
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 0.329727
GPM6A glycoprotein M6A 0.328994
PRLH prolactin releasing hormone 0.32497
TAL2 T-cell acute lymphocytic leukemia 2 0.323144
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.322779
CEND1 cell cycle exit and neuronal differentiation 1 0.322414
HELT helt bHLH transcription factor 0.321685
GLB1 galactosidase, beta 1 0.32132
LHB luteinizing hormone beta polypeptide 0.320956
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.319498
NCAM1 neural cell adhesion molecule 1 0.318407
GAP43 growth associated protein 43 0.318407
CLIP1 CAP-GLY domain containing linker protein 1 0.318042
FGFR3 fibroblast growth factor receptor 3 0.317679
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.316224
CELF4 CUGBP, Elav-like family member 4 0.313683
NPB neuropeptide B 0.313683
CNTN4 contactin 4 0.312595
MAOA monoamine oxidase A 0.31187
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.310783
SYP synaptophysin 0.308974
STMN2 stathmin 2 0.308251
VIM vimentin 0.305361
LHX2 LIM homeobox 2 0.305001
DMBX1 diencephalon/mesencephalon homeobox 1 0.303559
MPEG1 macrophage expressed 1 0.301758
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.301398
CTNNBIP1 catenin, beta interacting protein 1 0.297089
CLCF1 cardiotrophin-like cytokine factor 1 0.296372
PCP4 Purkinje cell protein 4 0.296372
PCNA proliferating cell nuclear antigen 0.294223
NPAT nuclear protein, ataxia-telangiectasia locus 0.290652
MEIS1 Meis homeobox 1 0.289939
PRPH2 peripherin 2 (retinal degeneration, slow) 0.289582
ALPP alkaline phosphatase, placental 0.28887
PTS 6-pyruvoyltetrahydropterin synthase 0.287092
PTPRS protein tyrosine phosphatase, receptor type, S 0.284607
CLK1 CDC-like kinase 1 0.283545
BTNL2 butyrophilin-like 2 0.280717
MLF1 myeloid leukemia factor 1 0.280012
EPHA6 EPH receptor A6 0.280012
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.278251
PTPRD protein tyrosine phosphatase, receptor type, D 0.278251
KTN1 kinectin 1 (kinesin receptor) 0.274744
NEFH neurofilament, heavy polypeptide 0.274045
FRY furry homolog (Drosophila) 0.272649
SOX2 SRY (sex determining region Y)-box 2 0.270561
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.269867
CHRM2 cholinergic receptor, muscarinic 2 0.268482
DLD dihydrolipoamide dehydrogenase 0.264011
RLN1 relaxin 1 0.262986
TENM1 teneurin transmembrane protein 1 0.260945
PRELP proline/arginine-rich end leucine-rich repeat protein 0.260606
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 0.258917
NMUR1 neuromedin U receptor 1 0.2559
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.253578
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.253248
NEUROD6 neuronal differentiation 6 0.253248
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 0.252919
TOM1 target of myb1 (chicken) 0.251934
KIRREL3 kin of IRRE like 3 (Drosophila) 0.251934
EPT1 ethanolaminephosphotransferase 1 0.250953
WNT1 wingless-type MMTV integration site family, member 1 0.250301
HK1 hexokinase 1 0.250301
PTN pleiotrophin 0.24804
FOXP2 forkhead box P2 0.247079
ITGA8 integrin, alpha 8 0.24486
LHX5 LIM homeobox 5 0.244545
PRNP prion protein 0.244545
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 0.244232
ANOS1 anosmin 1 0.244232
CHPF chondroitin polymerizing factor 0.243918
CHRDL1 chordin-like 1 0.242672
DRD2 dopamine receptor D2 0.240216
SLC30A2 solute carrier family 30 (zinc transporter), member 2 0.234878
MBP myelin basic protein 0.23459
HOMER1 homer scaffolding protein 1 0.234302
NRCAM neuronal cell adhesion molecule 0.234302
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.232039
GRM6 glutamate receptor, metabotropic 6 0.230656
GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2, pseudogene 0.23011
PMCH pro-melanin-concentrating hormone 0.228497
PPY pancreatic polypeptide 0.228234
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.227707
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.225395
SOX13 SRY (sex determining region Y)-box 13 0.225395
NPTXR neuronal pentraxin receptor 0.224893
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.224398
TNC tenascin C 0.223906
SCP2 sterol carrier protein 2 0.223662
CNGB3 cyclic nucleotide gated channel beta 3 0.22246
PBX2 pre-B-cell leukemia homeobox 2 0.220378
GNRHR gonadotropin-releasing hormone receptor 0.220152
EDN1 endothelin 1 0.219485
INSC inscuteable homolog (Drosophila) 0.219047
FGF2 fibroblast growth factor 2 (basic) 0.21883
IRX6 iroquois homeobox 6 0.218186
RXRG retinoid X receptor, gamma 0.21673
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 0.215928
DNM2 dynamin 2 0.215534
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.215147
DNAH8 dynein, axonemal, heavy chain 8 0.214954
AVP arginine vasopressin 0.214765
BBS2 Bardet-Biedl syndrome 2 0.214202
SON SON DNA binding protein 0.214202
QPRT quinolinate phosphoribosyltransferase 0.212586