open Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

311 genes co-occuring with the biological term open in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACSL3 acyl-CoA synthetase long-chain family member 3
ADA adenosine deaminase
ADARB1 adenosine deaminase, RNA-specific, B1
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
AIRE autoimmune regulator
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANO2 anoctamin 2, calcium activated chloride channel
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APMAP adipocyte plasma membrane associated protein
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
APRT adenine phosphoribosyltransferase
AQP1 aquaporin 1 (Colton blood group)
ARF1 ADP-ribosylation factor 1
ARX aristaless related homeobox
ASB10 ankyrin repeat and SOCS box containing 10
ATP7B ATPase, Cu++ transporting, beta polypeptide
BACE1 beta-site APP-cleaving enzyme 1
BCAR4 breast cancer anti-estrogen resistance 4 (non-protein coding)
BCKDK branched chain ketoacid dehydrogenase kinase
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L12 BCL2-like 12 (proline rich)
BDNF brain-derived neurotrophic factor
BIRC2 baculoviral IAP repeat containing 2
C14ORF1 chromosome 14 open reading frame 1
C19ORF24 chromosome 19 open reading frame 24
C3 complement component 3
C9ORF72 chromosome 9 open reading frame 72
CABP7 calcium binding protein 7
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CADPS Ca++-dependent secretion activator
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CD151 CD151 molecule (Raph blood group)
CD27 CD27 molecule
CD46 CD46 molecule, complement regulatory protein
CD70 CD70 molecule
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDKN2B-AS1 CDKN2B antisense RNA 1
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CFD complement factor D (adipsin)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHMP4A charged multivesicular body protein 4A
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHSY3 chondroitin sulfate synthase 3
CIITA class II, major histocompatibility complex, transactivator
CLCN1 chloride channel, voltage-sensitive 1
COL8A1 collagen, type VIII, alpha 1
COL8A2 collagen, type VIII, alpha 2
COMMD1 copper metabolism (Murr1) domain containing 1
CP ceruloplasmin (ferroxidase)
CPLX1 complexin 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTCF CCCTC-binding factor (zinc finger protein)
CTCFL CCCTC-binding factor (zinc finger protein)-like
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYCS cytochrome c, somatic
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
CYS1 cystin 1
DCK deoxycytidine kinase
DCX doublecortin
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIO2 deiodinase, iodothyronine, type II
DNM2 dynamin 2
DUOX2 dual oxidase 2
DUX4 double homeobox 4
E2F1 E2F transcription factor 1
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN2 egl-9 family hypoxia-inducible factor 2
ELN elastin
EPB42 erythrocyte membrane protein band 4.2
EPHA5 EPH receptor A5
ERBB3 erb-b2 receptor tyrosine kinase 3
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERRFI1 ERBB receptor feedback inhibitor 1
ESR1 estrogen receptor 1
F10 coagulation factor X
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FASA fertility associated sperm antigen
FASLG Fas ligand (TNF superfamily, member 6)
FLT3 fms-related tyrosine kinase 3
FNBP1L formin binding protein 1-like
FYN FYN proto-oncogene, Src family tyrosine kinase
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GAMT guanidinoacetate N-methyltransferase
GCK glucokinase (hexokinase 4)
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GFI1B growth factor independent 1B transcription repressor
GH1 growth hormone 1
GHRLOS ghrelin opposite strand/antisense RNA
GJA8 gap junction protein, alpha 8, 50kDa
GJB2 gap junction protein, beta 2, 26kDa
GJB6 gap junction protein, beta 6, 30kDa
GLI1 GLI family zinc finger 1
GLRA1 glycine receptor, alpha 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPER1 G protein-coupled estrogen receptor 1
GRAP2 GRB2-related adaptor protein 2
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HCAR2 hydroxycarboxylic acid receptor 2
HELQ helicase, POLQ-like
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB1 heat shock 27kDa protein 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
ICAM3 intercellular adhesion molecule 3
IFNB1 interferon, beta 1, fibroblast
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL33 interleukin 33
IL6 interleukin 6
IQCB1 IQ motif containing B1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB6 integrin, beta 6
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLK11 kallikrein-related peptidase 11
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KPNB1 karyopherin (importin) beta 1
KRIT1 KRIT1, ankyrin repeat containing
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LGALS1 lectin, galactoside-binding, soluble, 1
LIMS3 LIM and senescent cell antigen-like domains 3
LOXL1 lysyl oxidase-like 1
LRRK2 leucine-rich repeat kinase 2
LTBP2 latent transforming growth factor beta binding protein 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEFV Mediterranean fever
MEN1 multiple endocrine neoplasia I
MIR122 microRNA 122
MIR34A microRNA 34a
MMP1 matrix metallopeptidase 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVP major vault protein
MYDGF myeloid-derived growth factor
MYEOV myeloma overexpressed
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCOR1 nuclear receptor corepressor 1
NCR3 natural cytotoxicity triggering receptor 3
NEK6 NIMA-related kinase 6
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NF2 neurofibromin 2 (merlin)
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NPC2 Niemann-Pick disease, type C2
NPPB natriuretic peptide B
NPY1R neuropeptide Y receptor Y1
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRG2 neuregulin 2
NT5E 5'-nucleotidase, ecto (CD73)
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUMA1 nuclear mitotic apparatus protein 1
OLFML3 olfactomedin-like 3
OPA1 optic atrophy 1 (autosomal dominant)
OPTN optineurin
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PADI2 peptidyl arginine deiminase, type II
PATL1 protein associated with topoisomerase II homolog 1 (yeast)
PAX6 paired box 6
PCSK9 proprotein convertase subtilisin/kexin type 9
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PELP1 proline, glutamate and leucine rich protein 1
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PNLIPRP2 pancreatic lipase-related protein 2
POU1F1 POU class 1 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RB1 retinoblastoma 1
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
REST RE1-silencing transcription factor
RLN1 relaxin 1
RNPS1 RNA binding protein S1, serine-rich domain
RORA RAR-related orphan receptor A
RPGR retinitis pigmentosa GTPase regulator
RYR1 ryanodine receptor 1 (skeletal)
RYR3 ryanodine receptor 3
S100A10 S100 calcium binding protein A10
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SEC14L3 SEC14-like 3 (S. cerevisiae)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERBP1 SERPINE1 mRNA binding protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIX6 SIX homeobox 6
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMN1 survival of motor neuron 1, telomeric
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SP4 Sp4 transcription factor
SSPN sarcospan
STAB1 stabilin 1
STAT5B signal transducer and activator of transcription 5B
STX1A syntaxin 1A (brain)
SUFU suppressor of fused homolog (Drosophila)
SYT10 synaptotagmin X
TAAR1 trace amine associated receptor 1
TAAR2 trace amine associated receptor 2
TAC3 tachykinin 3
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAL1 T-cell acute lymphocytic leukemia 1
TBK1 TANK-binding kinase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TF transferrin
TGM2 transglutaminase 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMCO1 transmembrane and coiled-coil domains 1
TMPRSS11E transmembrane protease, serine 11E
TMPRSS2 transmembrane protease, serine 2
TMX2 thioredoxin-related transmembrane protein 2
TNF tumor necrosis factor
TNNC1 troponin C type 1 (slow)
TNNI3 troponin I type 3 (cardiac)
TP53 tumor protein p53
TP73 tumor protein p73
TPM1 tropomyosin 1 (alpha)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPM5 transient receptor potential cation channel, subfamily M, member 5
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TSPO translocator protein (18kDa)
TTK TTK protein kinase
TTPA tocopherol (alpha) transfer protein
TTR transthyretin
TXN thioredoxin
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UNC13A unc-13 homolog A (C. elegans)
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WDR36 WD repeat domain 36
XYLB xylulokinase homolog (H. influenzae)
ZBTB18 zinc finger and BTB domain containing 18
ZNF141 zinc finger protein 141