ondansetron-6270 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the ondansetron-6270 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGFG2 ArfGAP with FG repeats 2
AKAP7 A kinase (PRKA) anchor protein 7
ALPK1 alpha-kinase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARF6 ADP-ribosylation factor 6
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAIAP2 BAI1-associated protein 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BIN1 bridging integrator 1
CAMKMT calmodulin-lysine N-methyltransferase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CHMP7 charged multivesicular body protein 7
COL7A1 collagen, type VII, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CUL4B cullin 4B
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18
DCAF4 DDB1 and CUL4 associated factor 4
DCN decorin
DIXDC1 DIX domain containing 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOCK4 dedicator of cytokinesis 4
EFHD1 EF-hand domain family, member D1
EIF3F eukaryotic translation initiation factor 3, subunit F
ESRRA estrogen-related receptor alpha
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXTL3 exostosin-like glycosyltransferase 3
FAM134B family with sequence similarity 134, member B
FAM214B family with sequence similarity 214, member B
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FSCN3 fascin actin-bundling protein 3, testicular
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GLRX3 glutaredoxin 3
GSTCD glutathione S-transferase, C-terminal domain containing
HFE hemochromatosis
HNMT histamine N-methyltransferase
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOXC5 homeobox C5
HPS4 Hermansky-Pudlak syndrome 4
INO80D INO80 complex subunit D
IRF4 interferon regulatory factor 4
ITGB6 integrin, beta 6
KAT8 K(lysine) acetyltransferase 8
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNIP1 Kv channel interacting protein 1
KDM6A lysine (K)-specific demethylase 6A
KDM8 lysine (K)-specific demethylase 8
KLF6 Kruppel-like factor 6
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIMK2 LIM domain kinase 2
LPIN2 lipin 2
LRRC61 leucine rich repeat containing 61
MTMR7 myotubularin related protein 7
MYOF myoferlin
NCF4 neutrophil cytosolic factor 4, 40kDa
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NRG2 neuregulin 2
NUMA1 nuclear mitotic apparatus protein 1
PALM paralemmin
PAWR PRKC, apoptosis, WT1, regulator
PGPEP1 pyroglutamyl-peptidase I
PLAUR plasminogen activator, urokinase receptor
POU2F2 POU class 2 homeobox 2
PPT2 palmitoyl-protein thioesterase 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTDSS2 phosphatidylserine synthase 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RER1 retention in endoplasmic reticulum sorting receptor 1
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SETD1A SET domain containing 1A
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC12A8 solute carrier family 12, member 8
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNTA1 syntrophin, alpha 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SRCAP Snf2-related CREBBP activator protein
SREBF2 sterol regulatory element binding transcription factor 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STRN striatin, calmodulin binding protein
SUGP1 SURP and G patch domain containing 1
TAOK2 TAO kinase 2
TLE4 transducin-like enhancer of split 4
TMEM259 transmembrane protein 259
TP53I11 tumor protein p53 inducible protein 11
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC28 tetratricopeptide repeat domain 28
TTC33 tetratricopeptide repeat domain 33
TTLL1 tubulin tyrosine ligase-like family member 1
UBOX5 U-box domain containing 5
UBXN1 UBX domain protein 1
VAX2 ventral anterior homeobox 2
XDH xanthine dehydrogenase
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACTL8 actin-like 8
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD5 ATPase family, AAA domain containing 5
BEX4 brain expressed, X-linked 4
C14ORF132 chromosome 14 open reading frame 132
CAPN15 calpain 15
CCDC25 coiled-coil domain containing 25
CDKL3 cyclin-dependent kinase-like 3
CENPJ centromere protein J
CLDN15 claudin 15
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNR2 cannabinoid receptor 2 (macrophage)
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CXORF56 chromosome X open reading frame 56
DDIT3 DNA-damage-inducible transcript 3
DSCAM Down syndrome cell adhesion molecule
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERO1L ERO1-like (S. cerevisiae)
EVPL envoplakin
F8 coagulation factor VIII, procoagulant component
FANCC Fanconi anemia, complementation group C
FBRS fibrosin
FCHSD2 FCH and double SH3 domains 2
FKBP14 FK506 binding protein 14, 22 kDa
FLCN folliculin
FMO4 flavin containing monooxygenase 4
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45G growth arrest and DNA-damage-inducible, gamma
GID4 GID complex subunit 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLCE glucuronic acid epimerase
GLS2 glutaminase 2 (liver, mitochondrial)
HIST1H2BF histone cluster 1, H2bf
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOOK1 hook microtubule-tethering protein 1
IFT22 intraflagellar transport 22
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
KLHL21 kelch-like family member 21
LIN37 lin-37 DREAM MuvB core complex component
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LRRC20 leucine rich repeat containing 20
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAP9 microtubule-associated protein 9
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MT1H metallothionein 1H
MTRF1 mitochondrial translational release factor 1
MYO1D myosin ID
NDFIP1 Nedd4 family interacting protein 1
NPIPB15 nuclear pore complex interacting protein family, member B15
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PGBD5 piggyBac transposable element derived 5
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POMT2 protein-O-mannosyltransferase 2
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPRE protein tyrosine phosphatase, receptor type, E
PYGB phosphorylase, glycogen; brain
RANBP17 RAN binding protein 17
RASA2 RAS p21 protein activator 2
RCOR3 REST corepressor 3
REPS2 RALBP1 associated Eps domain containing 2
RNF39 ring finger protein 39
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERTAD3 SERTA domain containing 3
SETD8 SET domain containing (lysine methyltransferase) 8
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC25A40 solute carrier family 25, member 40
SLC46A3 solute carrier family 46, member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SND1-IT1 SND1 intronic transcript 1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SYCP2 synaptonemal complex protein 2
TAGLN transgelin
TBC1D10B TBC1 domain family, member 10B
TLN1 talin 1
TMEM2 transmembrane protein 2
TPST1 tyrosylprotein sulfotransferase 1
TTC23 tetratricopeptide repeat domain 23
UBXN6 UBX domain protein 6
YBX2 Y box binding protein 2
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H3 zinc finger CCCH-type containing 3
ZMAT5 zinc finger, matrin-type 5
ZNF141 zinc finger protein 141
ZNF205 zinc finger protein 205
ZNF219 zinc finger protein 219
ZNF442 zinc finger protein 442
ZNF480 zinc finger protein 480
ZNF586 zinc finger protein 586
ZNF813 zinc finger protein 813