nuclear replisome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. (Gene Ontology, GO_0043601)
Similar Terms
Downloads & Tools

Genes

211 proteins co-occuring with the nuclear replisome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TRIM21 tripartite motif containing 21 2.22541
RPA2 replication protein A2, 32kDa 2.20669
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 2.02493
RPA1 replication protein A1, 70kDa 2.02204
RAD51 RAD51 recombinase 1.83883
RFC1 replication factor C (activator 1) 1, 145kDa 1.82524
RFC4 replication factor C (activator 1) 4, 37kDa 1.80841
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.79375
RFC3 replication factor C (activator 1) 3, 38kDa 1.78189
XPA xeroderma pigmentosum, complementation group A 1.78058
RFC2 replication factor C (activator 1) 2, 40kDa 1.77144
RAD52 RAD52 homolog (S. cerevisiae) 1.72619
PCNA proliferating cell nuclear antigen 1.69216
CHEK1 checkpoint kinase 1 1.64793
ATM ATM serine/threonine kinase 1.5565
ATRIP ATR interacting protein 1.50396
FEN1 flap structure-specific endonuclease 1 1.48475
DNA2 DNA replication helicase/nuclease 2 1.48362
WRN Werner syndrome, RecQ helicase-like 1.46439
RPA3 replication protein A3, 14kDa 1.44686
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.29639
TROVE2 TROVE domain family, member 2 1.2905
ATR ATR serine/threonine kinase 1.28036
EXO1 exonuclease 1 1.26181
SSB Sjogren syndrome antigen B (autoantigen La) 1.24498
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.22984
TOP1 topoisomerase (DNA) I 1.22984
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.20292
PURB purine-rich element binding protein B 1.20189
LIG1 ligase I, DNA, ATP-dependent 1.18903
RPA4 replication protein A4, 30kDa 1.18492
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.15774
RECQL RecQ helicase-like 1.14494
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 1.10664
PRIM1 primase, DNA, polypeptide 1 (49kDa) 1.10562
ERCC5 excision repair cross-complementation group 5 1.05942
RAD9A RAD9 homolog A (S. pombe) 1.05236
PLAT plasminogen activator, tissue 1.04481
NABP2 nucleic acid binding protein 2 1.02729
RAD17 RAD17 homolog (S. pombe) 1.003
RMI1 RecQ mediated genome instability 1 1.00202
CLSPN claspin 0.995142
TP53 tumor protein p53 0.98488
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.981473
ERCC1 excision repair cross-complementation group 1 0.975166
DMWD dystrophia myotonica, WD repeat containing 0.972747
H2AFX H2A histone family, member X 0.968401
ERCC4 excision repair cross-complementation group 4 0.961187
TIPIN TIMELESS interacting protein 0.938795
BRCA2 breast cancer 2, early onset 0.937377
XPC xeroderma pigmentosum, complementation group C 0.914842
PAPD7 PAP associated domain containing 7 0.913443
SP100 SP100 nuclear antigen 0.887012
HSPG2 heparan sulfate proteoglycan 2 0.873186
HSPA4 heat shock 70kDa protein 4 0.846532
BLM Bloom syndrome, RecQ helicase-like 0.843778
TOPBP1 topoisomerase (DNA) II binding protein 1 0.843778
SSBP1 single-stranded DNA binding protein 1, mitochondrial 0.82037
MLH1 mutL homolog 1 0.803396
RAD23B RAD23 homolog B (S. cerevisiae) 0.777755
TICAM2 toll-like receptor adaptor molecule 2 0.773645
RFWD3 ring finger and WD repeat domain 3 0.771363
RAD50 RAD50 homolog (S. cerevisiae) 0.768627
RECQL4 RecQ protein-like 4 0.755437
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.74322
POLL polymerase (DNA directed), lambda 0.740064
AICDA activation-induced cytidine deaminase 0.740064
CDK2 cyclin-dependent kinase 2 0.723026
HELB helicase (DNA) B 0.720797
SERTAD3 SERTA domain containing 3 0.720797
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.707482
BRCA1 breast cancer 1, early onset 0.706156
SSBP3 single stranded DNA binding protein 3 0.704831
RMI2 RecQ mediated genome instability 2 0.69427
RAD18 RAD18 E3 ubiquitin protein ligase 0.689451
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.68639
POT1 protection of telomeres 1 0.681591
UNG uracil-DNA glycosylase 0.679413
PPAN peter pan homolog (Drosophila) 0.6638
CDC45 cell division cycle 45 0.634159
HUS1 HUS1 checkpoint homolog (S. pombe) 0.632024
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.627761
MSH2 mutS homolog 2 0.619255
PRPH peripherin 0.613742
TOP3A topoisomerase (DNA) III alpha 0.599802
HLTF helicase-like transcription factor 0.581758
RPAIN RPA interacting protein 0.572994
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.560528
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.551838
CD79A CD79a molecule, immunoglobulin-associated alpha 0.547297
PIF1 PIF1 5'-to-3' DNA helicase 0.543176
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.542352
RNF4 ring finger protein 4 0.533309
POLH polymerase (DNA directed), eta 0.518165
NABP1 nucleic acid binding protein 1 0.513677
LIG3 ligase III, DNA, ATP-dependent 0.509604
REV1 REV1, polymerase (DNA directed) 0.504724
SPO11 SPO11 meiotic protein covalently bound to DSB 0.483273
RPAP1 RNA polymerase II associated protein 1 0.481258
PLG plasminogen 0.477233
KCTD5 potassium channel tetramerization domain containing 5 0.465998
DNAH8 dynein, axonemal, heavy chain 8 0.458404
CTC1 CTS telomere maintenance complex component 1 0.451233
MCM8 minichromosome maintenance complex component 8 0.447656
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.443689
MSH4 mutS homolog 4 0.434591
LIG4 ligase IV, DNA, ATP-dependent 0.431829
MDC1 mediator of DNA-damage checkpoint 1 0.430647
OR13H1 olfactory receptor, family 13, subfamily H, member 1 0.426711
SPAG11A sperm associated antigen 11A 0.425531
KLHL7 kelch-like family member 7 0.424745
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.41143
CENPB centromere protein B, 80kDa 0.405582
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.405193
SPAG11B sperm associated antigen 11B 0.399363
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.395873
RECQL5 RecQ protein-like 5 0.393936
SPATA22 spermatogenesis associated 22 0.388909
MLH3 mutL homolog 3 0.388137
POLB polymerase (DNA directed), beta 0.380814
ANXA2 annexin A2 0.37697
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.365859
SUB1 SUB1 homolog (S. cerevisiae) 0.365859
TRH thyrotropin-releasing hormone 0.363567
NCL nucleolin 0.358228
BCAS2 breast carcinoma amplified sequence 2 0.352522
RRH retinal pigment epithelium-derived rhodopsin homolog 0.352522
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 0.349105
GPR132 G protein-coupled receptor 132 0.343799
CDK1 cyclin-dependent kinase 1 0.342664
LDB1 LIM domain binding 1 0.339639
HELQ helicase, POLQ-like 0.337751
TMEM11 transmembrane protein 11 0.334733
FANCD2 Fanconi anemia, complementation group D2 0.333979
ZNF77 zinc finger protein 77 0.332848
USP1 ubiquitin specific peptidase 1 0.329837
TCTA T-cell leukemia translocation altered 0.326829
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.325327
A2M alpha-2-macroglobulin 0.323825
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 0.3227
PALB2 partner and localizer of BRCA2 0.321575
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.321201
IL17C interleukin 17C 0.316708
SSBP2 single-stranded DNA binding protein 2 0.310358
MRC1 mannose receptor, C type 1 0.308494
FUBP3 far upstream element (FUSE) binding protein 3 0.305143
SERTAD1 SERTA domain containing 1 0.304399
SETD8 SET domain containing (lysine methyltransferase) 8 0.301054
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.300311
RNASEH1 ribonuclease H1 0.296972
HIAT1 hippocampus abundant transcript 1 0.295489
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.290308
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.278509
YBX1 Y box binding protein 1 0.277406
FOS FBJ murine osteosarcoma viral oncogene homolog 0.274835
BTNL2 butyrophilin-like 2 0.273367
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.272267
NANS N-acetylneuraminic acid synthase 0.271533
UIMC1 ubiquitin interaction motif containing 1 0.271167
POLM polymerase (DNA directed), mu 0.270068
NEIL2 nei endonuclease VIII-like 2 (E. coli) 0.26239
KLHL12 kelch-like family member 12 0.259109
PRTN3 proteinase 3 0.259109
IFI16 interferon, gamma-inducible protein 16 0.256561
PLRG1 pleiotropic regulator 1 0.25547
POLN polymerase (DNA directed) nu 0.246769
MCMBP minichromosome maintenance complex binding protein 0.246046
HAUS3 HAUS augmin-like complex, subunit 3 0.245323
NBN nibrin 0.245323
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.244962
NLRP5 NLR family, pyrin domain containing 5 0.243519
CDK7 cyclin-dependent kinase 7 0.234533
RLIM ring finger protein, LIM domain interacting 0.233101
WDR11 WD repeat domain 11 0.231672
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.228819
CDA cytidine deaminase 0.228108
GALK1 galactokinase 1 0.227752
TRIM24 tripartite motif containing 24 0.223143
CDC7 cell division cycle 7 0.22173
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.217511
RPL23 ribosomal protein L23 0.213669
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.209513
ATAD3C ATPase family, AAA domain containing 3C 0.208825
SYCP1 synaptonemal complex protein 1 0.207794
LCT lactase 0.199993
PARP1 poly (ADP-ribose) polymerase 1 0.19733
MSH3 mutS homolog 3 0.196999
CALR calreticulin 0.186708
RPAP3 RNA polymerase II associated protein 3 0.186397
C4A complement component 4A (Rodgers blood group) 0.186087
MSH6 mutS homolog 6 0.181227
ADAT2 adenosine deaminase, tRNA-specific 2 0.178588
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.178588
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.178588
TIMELESS timeless circadian clock 0.178011
SENP6 SUMO1/sentrin specific peptidase 6 0.178011
DSCC1 DNA replication and sister chromatid cohesion 1 0.177724
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.17687
MCM2 minichromosome maintenance complex component 2 0.176305
PASK PAS domain containing serine/threonine kinase 0.174087
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.172201
RAD51D RAD51 paralog D 0.167611
RPL39 ribosomal protein L39 0.167366
RBBP8 retinoblastoma binding protein 8 0.166884
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.166405
STK39 serine threonine kinase 39 0.164542
PML promyelocytic leukemia 0.1632
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.16298
TPH1 tryptophan hydroxylase 1 0.16298
MCM7 minichromosome maintenance complex component 7 0.158129
CSN2 casein beta 0.157218