nuclear replication fork Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. (Gene Ontology, GO_0043596)
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Genes

220 proteins co-occuring with the nuclear replication fork cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TRIM21 tripartite motif containing 21 2.2179
RPA2 replication protein A2, 32kDa 2.19851
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 2.01772
RPA1 replication protein A1, 70kDa 2.01484
RFC1 replication factor C (activator 1) 1, 145kDa 1.83338
RAD51 RAD51 recombinase 1.83203
RFC4 replication factor C (activator 1) 4, 37kDa 1.81714
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.80239
RFC3 replication factor C (activator 1) 3, 38kDa 1.79111
RFC2 replication factor C (activator 1) 2, 40kDa 1.77927
XPA xeroderma pigmentosum, complementation group A 1.77405
RAD52 RAD52 homolog (S. cerevisiae) 1.75852
PCNA proliferating cell nuclear antigen 1.69706
CHEK1 checkpoint kinase 1 1.67568
ATM ATM serine/threonine kinase 1.55084
ATRIP ATR interacting protein 1.49831
FEN1 flap structure-specific endonuclease 1 1.47853
DNA2 DNA replication helicase/nuclease 2 1.47796
WRN Werner syndrome, RecQ helicase-like 1.45873
RPA3 replication protein A3, 14kDa 1.44121
ATR ATR serine/threonine kinase 1.29424
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.29103
TROVE2 TROVE domain family, member 2 1.28516
EXO1 exonuclease 1 1.25653
TOP1 topoisomerase (DNA) I 1.25285
SSB Sjogren syndrome antigen B (autoantigen La) 1.23975
TIPIN TIMELESS interacting protein 1.22828
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.22464
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 1.19726
PURB purine-rich element binding protein B 1.19674
LIG1 ligase I, DNA, ATP-dependent 1.18389
RPA4 replication protein A4, 30kDa 1.17978
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.15262
RECQL RecQ helicase-like 1.13983
CLSPN claspin 1.10715
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 1.10154
PRIM1 primase, DNA, polypeptide 1 (49kDa) 1.10053
ERCC5 excision repair cross-complementation group 5 1.05387
RAD9A RAD9 homolog A (S. pombe) 1.04733
PLAT plasminogen activator, tissue 1.0398
NABP2 nucleic acid binding protein 2 1.02181
RAD17 RAD17 homolog (S. pombe) 0.998086
RMI1 RecQ mediated genome instability 1 0.997104
TP53 tumor protein p53 0.980016
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.976619
ERCC1 excision repair cross-complementation group 1 0.970331
DMWD dystrophia myotonica, WD repeat containing 0.96792
H2AFX H2A histone family, member X 0.963588
ERCC4 excision repair cross-complementation group 4 0.956395
BRCA2 breast cancer 2, early onset 0.932658
XPC xeroderma pigmentosum, complementation group C 0.909716
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.909251
PAPD7 PAP associated domain containing 7 0.908785
CDC45 cell division cycle 45 0.894406
SP100 SP100 nuclear antigen 0.882399
HSPG2 heparan sulfate proteoglycan 2 0.868126
HSPA4 heat shock 70kDa protein 4 0.841941
TOPBP1 topoisomerase (DNA) II binding protein 1 0.839187
BLM Bloom syndrome, RecQ helicase-like 0.838728
SSBP1 single-stranded DNA binding protein 1, mitochondrial 0.815781
MLH1 mutL homolog 1 0.798811
RAD23B RAD23 homolog B (S. cerevisiae) 0.773188
TICAM2 toll-like receptor adaptor molecule 2 0.769083
RFWD3 ring finger and WD repeat domain 3 0.766804
RAD50 RAD50 homolog (S. cerevisiae) 0.763617
RECQL4 RecQ protein-like 4 0.750452
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.738713
POLL polymerase (DNA directed), lambda 0.735565
AICDA activation-induced cytidine deaminase 0.735565
CDK2 cyclin-dependent kinase 2 0.71857
HELB helicase (DNA) B 0.716346
SERTAD3 SERTA domain containing 3 0.716346
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.703067
BRCA1 breast cancer 1, early onset 0.701744
SSBP3 single stranded DNA binding protein 3 0.700423
RMI2 RecQ mediated genome instability 2 0.689888
RAD18 RAD18 E3 ubiquitin protein ligase 0.68508
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.682027
POT1 protection of telomeres 1 0.677238
UNG uracil-DNA glycosylase 0.675065
PPAN peter pan homolog (Drosophila) 0.659482
MRC1 mannose receptor, C type 1 0.639289
TIMELESS timeless circadian clock 0.635868
HUS1 HUS1 checkpoint homolog (S. pombe) 0.627761
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.623504
MSH2 mutS homolog 2 0.615013
PRPH peripherin 0.609509
MCM2 minichromosome maintenance complex component 2 0.596855
TOP3A topoisomerase (DNA) III alpha 0.595593
HLTF helicase-like transcription factor 0.577164
RPAIN RPA interacting protein 0.568832
MCM7 minichromosome maintenance complex component 7 0.565092
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.556387
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.54771
CD79A CD79a molecule, immunoglobulin-associated alpha 0.543176
PIF1 PIF1 5'-to-3' DNA helicase 0.53906
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.538238
RNF4 ring finger protein 4 0.529208
POLH polymerase (DNA directed), eta 0.514085
NABP1 nucleic acid binding protein 1 0.509197
LIG3 ligase III, DNA, ATP-dependent 0.505537
REV1 REV1, polymerase (DNA directed) 0.500258
SPO11 SPO11 meiotic protein covalently bound to DSB 0.479245
RPAP1 RNA polymerase II associated protein 1 0.476831
PLG plasminogen 0.473215
KCTD5 potassium channel tetramerization domain containing 5 0.461998
DNAH8 dynein, axonemal, heavy chain 8 0.454418
CTC1 CTS telomere maintenance complex component 1 0.447259
MCM8 minichromosome maintenance complex component 8 0.443689
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.439728
MSH4 mutS homolog 4 0.430647
LIG4 ligase IV, DNA, ATP-dependent 0.427891
MDC1 mediator of DNA-damage checkpoint 1 0.426711
OR13H1 olfactory receptor, family 13, subfamily H, member 1 0.422389
SPAG11A sperm associated antigen 11A 0.421604
KLHL7 kelch-like family member 7 0.42082
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.407529
CENPB centromere protein B, 80kDa 0.401693
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.400916
SPAG11B sperm associated antigen 11B 0.395485
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.391615
RECQL5 RecQ protein-like 5 0.390068
SPATA22 spermatogenesis associated 22 0.385051
MLH3 mutL homolog 3 0.38428
POLB polymerase (DNA directed), beta 0.37697
ANXA2 annexin A2 0.373132
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.36204
SUB1 SUB1 homolog (S. cerevisiae) 0.361659
TRH thyrotropin-releasing hormone 0.359752
NCL nucleolin 0.354422
RRH retinal pigment epithelium-derived rhodopsin homolog 0.348725
BCAS2 breast carcinoma amplified sequence 2 0.348346
CDC7 cell division cycle 7 0.345692
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 0.345314
GPR132 G protein-coupled receptor 132 0.340017
CDK1 cyclin-dependent kinase 1 0.338884
LDB1 LIM domain binding 1 0.335864
HELQ helicase, POLQ-like 0.333979
ATAD5 ATPase family, AAA domain containing 5 0.333225
TMEM11 transmembrane protein 11 0.330966
FANCD2 Fanconi anemia, complementation group D2 0.330213
ZNF77 zinc finger protein 77 0.329084
USP1 ubiquitin specific peptidase 1 0.326078
TELO2 telomere maintenance 2 0.324201
TCTA T-cell leukemia translocation altered 0.3227
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.321575
A2M alpha-2-macroglobulin 0.320077
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 0.318579
PALB2 partner and localizer of BRCA2 0.31783
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.317456
MCM4 minichromosome maintenance complex component 4 0.316334
IL17C interleukin 17C 0.312971
SSBP2 single-stranded DNA binding protein 2 0.306632
FUBP3 far upstream element (FUSE) binding protein 3 0.301425
SERTAD1 SERTA domain containing 1 0.300682
SETD8 SET domain containing (lysine methyltransferase) 8 0.297342
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.296601
DBF4 DBF4 zinc finger 0.293637
RNASEH1 ribonuclease H1 0.293267
HIAT1 hippocampus abundant transcript 1 0.291787
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.286614
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.274835
YBX1 Y box binding protein 1 0.273734
FOS FBJ murine osteosarcoma viral oncogene homolog 0.271167
BTNL2 butyrophilin-like 2 0.269701
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.268237
NANS N-acetylneuraminic acid synthase 0.267871
UIMC1 ubiquitin interaction motif containing 1 0.267505
POLM polymerase (DNA directed), mu 0.266408
NEIL2 nei endonuclease VIII-like 2 (E. coli) 0.258745
PRTN3 proteinase 3 0.25547
KLHL12 kelch-like family member 12 0.25547
IFI16 interferon, gamma-inducible protein 16 0.252927
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.252564
PLRG1 pleiotropic regulator 1 0.251839
POLN polymerase (DNA directed) nu 0.243158
MCMBP minichromosome maintenance complex binding protein 0.242437
NBN nibrin 0.241716
HAUS3 HAUS augmin-like complex, subunit 3 0.241716
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.241356
NLRP5 NLR family, pyrin domain containing 5 0.239557
CDK7 cyclin-dependent kinase 7 0.230958
RLIM ring finger protein, LIM domain interacting 0.229532
WDR11 WD repeat domain 11 0.228108
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.225267
CDA cytidine deaminase 0.224204
GALK1 galactokinase 1 0.224204
TRIM24 tripartite motif containing 24 0.219617
MCM5 minichromosome maintenance complex component 5 0.216111
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.214017
RPL23 ribosomal protein L23 0.210203
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.20574
ATAD3C ATPase family, AAA domain containing 3C 0.205399
SYCP1 synaptonemal complex protein 1 0.204378
MCM10 minichromosome maintenance complex component 10 0.199659
LCT lactase 0.196669
PARP1 poly (ADP-ribose) polymerase 1 0.194045
MSH3 mutS homolog 3 0.193719
RPAP3 RNA polymerase II associated protein 3 0.183328
CALR calreticulin 0.183328
C4A complement component 4A (Rodgers blood group) 0.183025
MSH6 mutS homolog 6 0.178299
ADAT2 adenosine deaminase, tRNA-specific 2 0.175745
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.175745
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.175466
SENP6 SUMO1/sentrin specific peptidase 6 0.175188
DSCC1 DNA replication and sister chromatid cohesion 1 0.174911
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.173814
PASK PAS domain containing serine/threonine kinase 0.17141
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.169604
RAD51D RAD51 paralog D 0.165231
RPL39 ribosomal protein L39 0.165
RBBP8 retinoblastoma binding protein 8 0.164542
DDX11L8 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 like 8 0.164315
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.163865
STK39 serine threonine kinase 39 0.16233
PML promyelocytic leukemia 0.161068
TPH1 tryptophan hydroxylase 1 0.160863
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.160863
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 0.157218