nuclear pre-replicative complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins. (Gene Ontology, GO_0005656)
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115 proteins co-occuring with the nuclear pre-replicative complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
CDC6 cell division cycle 6 2.58474
MCM7 minichromosome maintenance complex component 7 2.39351
MCM2 minichromosome maintenance complex component 2 2.35528
CDT1 chromatin licensing and DNA replication factor 1 2.13768
GMNN geminin, DNA replication inhibitor 1.99619
CDC45 cell division cycle 45 1.70137
MCM6 minichromosome maintenance complex component 6 1.65814
MUT methylmalonyl CoA mutase 1.45138
CDC7 cell division cycle 7 1.4446
DBF4 DBF4 zinc finger 1.41082
MCM3 minichromosome maintenance complex component 3 1.39183
CDK2 cyclin-dependent kinase 2 1.35156
MCM10 minichromosome maintenance complex component 10 1.2708
MCM4 minichromosome maintenance complex component 4 1.22776
MCM9 minichromosome maintenance complex component 9 1.17671
MCM5 minichromosome maintenance complex component 5 1.12603
LMNB2 lamin B2 1.01734
ORC3 origin recognition complex, subunit 3 0.982446
KAT7 K(lysine) acetyltransferase 7 0.960707
ODC1 ornithine decarboxylase 1 0.864907
PCNA proliferating cell nuclear antigen 0.850206
LRWD1 leucine-rich repeats and WD repeat domain containing 1 0.840105
DDB1 damage-specific DNA binding protein 1, 127kDa 0.834138
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.825418
WDR83 WD repeat domain 83 0.798811
MCMBP minichromosome maintenance complex binding protein 0.747737
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta 0.689451
PRPF38A pre-mRNA processing factor 38A 0.679413
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.65259
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 0.647003
CDK1 cyclin-dependent kinase 1 0.617557
GCG glucagon 0.608241
MAX MYC associated factor X 0.577581
DCTD dCMP deaminase 0.574662
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.574662
FBXO5 F-box protein 5 0.5568
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.519389
INS insulin 0.501881
LIG1 ligase I, DNA, ATP-dependent 0.500664
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.483676
NIPBL Nipped-B homolog (Drosophila) 0.477636
FOS FBJ murine osteosarcoma viral oncogene homolog 0.472412
NEIL2 nei endonuclease VIII-like 2 (E. coli) 0.462398
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.440124
PLK1 polo-like kinase 1 0.433801
TOPBP1 topoisomerase (DNA) II binding protein 1 0.424745
CDK4 cyclin-dependent kinase 4 0.416511
HPD 4-hydroxyphenylpyruvate dioxygenase 0.405971
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.405582
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.405193
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.405193
TEN1 TEN1 CST complex subunit 0.398587
CDC25A cell division cycle 25A 0.398199
RECQL4 RecQ protein-like 4 0.397811
TP53 tumor protein p53 0.397811
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.364713
HMGB3 high mobility group box 3 0.364331
CCND3 cyclin D3 0.363949
WAC WW domain containing adaptor with coiled-coil 0.358228
CHEK1 checkpoint kinase 1 0.353662
SMC3 structural maintenance of chromosomes 3 0.351002
LIG3 ligase III, DNA, ATP-dependent 0.350243
CUL4A cullin 4A 0.346071
HOXD11 homeobox D11 0.343042
CCND1 cyclin D1 0.330589
ATR ATR serine/threonine kinase 0.330213
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.329084
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.324951
DMWD dystrophia myotonica, WD repeat containing 0.320077
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.311105
PTPRK protein tyrosine phosphatase, receptor type, K 0.310732
MCM8 minichromosome maintenance complex component 8 0.307004
CCNA2 cyclin A2 0.302168
HOXA13 homeobox A13 0.284769
GCAT glycine C-acetyltransferase 0.284401
LIG4 ligase IV, DNA, ATP-dependent 0.277774
HOXD13 homeobox D13 0.264946
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.264581
RRM1 ribonucleotide reductase M1 0.262755
DHFR dihydrofolate reductase 0.261296
H3F3B H3 histone, family 3B (H3.3B) 0.260931
H3F3A H3 histone, family 3A 0.260931
ATM ATM serine/threonine kinase 0.260202
FGF1 fibroblast growth factor 1 (acidic) 0.256197
HOXC13 homeobox C13 0.252564
S100A6 S100 calcium binding protein A6 0.24894
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.24894
SIM2 single-minded family bHLH transcription factor 2 0.24424
DNAH8 dynein, axonemal, heavy chain 8 0.239557
CCNE2 cyclin E2 0.229176
PHC1 polyhomeotic homolog 1 (Drosophila) 0.228819
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.22385
OCM oncomodulin 0.219617
AR androgen receptor 0.217861
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.217511
CCDC88A coiled-coil domain containing 88A 0.210203
OCM2 oncomodulin 2 0.20574
HOXB4 homeobox B4 0.203022
HPX hemopexin 0.200999
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 0.199993
HMGA1 high mobility group AT-hook 1 0.191456
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.186397
FEN1 flap structure-specific endonuclease 1 0.186087
CBX5 chromobox homolog 5 0.185777
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.179459
HLA-G major histocompatibility complex, class I, G 0.174911
CSN1S1 casein alpha s1 0.172735
TGFB1 transforming growth factor, beta 1 0.172201
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.170114
IL2 interleukin 2 0.169099
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.165231
NCL nucleolin 0.164089
PIAS3 protein inhibitor of activated STAT, 3 0.162546
PDGFA platelet-derived growth factor alpha polypeptide 0.159268
IGF1 insulin-like growth factor 1 (somatomedin C) 0.158692