novobiocin-342 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the novobiocin-342 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAP1 ArfGAP with dual PH domains 1
ADCY3 adenylate cyclase 3
ADRBK1 adrenergic, beta, receptor kinase 1
AHR aryl hydrocarbon receptor
ANKRD40 ankyrin repeat domain 40
AQP3 aquaporin 3 (Gill blood group)
AQP8 aquaporin 8
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCLAF1 BCL2-associated transcription factor 1
C1ORF159 chromosome 1 open reading frame 159
C6ORF106 chromosome 6 open reading frame 106
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD5 CD5 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CGA glycoprotein hormones, alpha polypeptide
CIDEB cell death-inducing DFFA-like effector b
CLIC4 chloride intracellular channel 4
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNTFR ciliary neurotrophic factor receptor
DLK2 delta-like 2 homolog (Drosophila)
DMBT1 deleted in malignant brain tumors 1
DXO decapping exoribonuclease
ECE1 endothelin converting enzyme 1
EFNB3 ephrin-B3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERCC4 excision repair cross-complementation group 4
ESR1 estrogen receptor 1
F5 coagulation factor V (proaccelerin, labile factor)
GADD45B growth arrest and DNA-damage-inducible, beta
GLB1L galactosidase, beta 1-like
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GP9 glycoprotein IX (platelet)
GRIK5 glutamate receptor, ionotropic, kainate 5
GUF1 GUF1 GTPase homolog (S. cerevisiae)
JAM2 junctional adhesion molecule 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KRT1 keratin 1, type II
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LINC00216 long intergenic non-protein coding RNA 216
LMBR1L limb development membrane protein 1-like
LUZP4 leucine zipper protein 4
MAPK10 mitogen-activated protein kinase 10
MBD3 methyl-CpG binding domain protein 3
MEFV Mediterranean fever
MNT MAX network transcriptional repressor
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MZF1 myeloid zinc finger 1
NBAS neuroblastoma amplified sequence
NF1 neurofibromin 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NPPA natriuretic peptide A
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL2 nucleoporin like 2
OR10H3 olfactory receptor, family 10, subfamily H, member 3
OR3A3 olfactory receptor, family 3, subfamily A, member 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSBPL10 oxysterol binding protein-like 10
PARG poly (ADP-ribose) glycohydrolase
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKD2L1 polycystic kidney disease 2-like 1
POFUT2 protein O-fucosyltransferase 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R17 protein phosphatase 1, regulatory subunit 17
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRDM14 PR domain containing 14
PRDM2 PR domain containing 2, with ZNF domain
PRSS53 protease, serine, 53
PTGDR2 prostaglandin D2 receptor 2
PYCRL pyrroline-5-carboxylate reductase-like
RAB3D RAB3D, member RAS oncogene family
RDH8 retinol dehydrogenase 8 (all-trans)
RPL10 ribosomal protein L10
RPS2 ribosomal protein S2
RSPH6A radial spoke head 6 homolog A (Chlamydomonas)
SCML1 sex comb on midleg-like 1 (Drosophila)
SH3BP2 SH3-domain binding protein 2
SLA Src-like-adaptor
SLC17A4 solute carrier family 17, member 4
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SMAD3 SMAD family member 3
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STX12 syntaxin 12
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
THBS3 thrombospondin 3
TMEM19 transmembrane protein 19
TOLLIP toll interacting protein
UBE2I ubiquitin-conjugating enzyme E2I
UBE4B ubiquitination factor E4B
UBOX5 U-box domain containing 5
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACSF2 acyl-CoA synthetase family member 2
ADORA3 adenosine A3 receptor
ARSF arylsulfatase F
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
BEAN1 brain expressed, associated with NEDD4, 1
BTNL2 butyrophilin-like 2
C19ORF73 chromosome 19 open reading frame 73
CA6 carbonic anhydrase VI
CAMKMT calmodulin-lysine N-methyltransferase
CBX7 chromobox homolog 7
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK5 cyclin-dependent kinase 5
CFAP70 cilia and flagella associated protein 70
CLEC1B C-type lectin domain family 1, member B
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CRYGB crystallin, gamma B
CSF1R colony stimulating factor 1 receptor
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DGAT1 diacylglycerol O-acyltransferase 1
DSCAM Down syndrome cell adhesion molecule
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDC4 enhancer of mRNA decapping 4
EN2 engrailed homeobox 2
ERO1L ERO1-like (S. cerevisiae)
EVPL envoplakin
F2 coagulation factor II (thrombin)
FAM63A family with sequence similarity 63, member A
FAM76A family with sequence similarity 76, member A
FOXC1 forkhead box C1
GLRA2 glycine receptor, alpha 2
GMIP GEM interacting protein
GSDMD gasdermin D
HIST1H3I histone cluster 1, H3i
HPN hepsin
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
IGKV1D-13 immunoglobulin kappa variable 1D-13
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
MANSC1 MANSC domain containing 1
MEPE matrix extracellular phosphoglycoprotein
MFSD12 major facilitator superfamily domain containing 12
MPPED1 metallophosphoesterase domain containing 1
MST1R macrophage stimulating 1 receptor
MTERF4 mitochondrial transcription termination factor 4
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NABP2 nucleic acid binding protein 2
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NR0B2 nuclear receptor subfamily 0, group B, member 2
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE12 phosphodiesterase 12
PFAS phosphoribosylformylglycinamidine synthase
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
PGM3 phosphoglucomutase 3
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PPL periplakin
PQLC3 PQ loop repeat containing 3
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRY PTPN13-like, Y-linked
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTK6 protein tyrosine kinase 6
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RAD54L RAD54-like (S. cerevisiae)
RAI14 retinoic acid induced 14
RBM22 RNA binding motif protein 22
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RHOH ras homolog family member H
RRAS related RAS viral (r-ras) oncogene homolog
SAMHD1 SAM domain and HD domain 1
SETD1A SET domain containing 1A
SIGLEC15 sialic acid binding Ig-like lectin 15
SKAP1 src kinase associated phosphoprotein 1
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNRPF small nuclear ribonucleoprotein polypeptide F
SNX6 sorting nexin 6
STAT5A signal transducer and activator of transcription 5A
T T, brachyury homolog (mouse)
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TMEM115 transmembrane protein 115
TMEM176A transmembrane protein 176A
TMEM57 transmembrane protein 57
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPCN1 two pore segment channel 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR13 WD repeat domain 13
XYLT2 xylosyltransferase II
ZFP30 ZFP30 zinc finger protein
ZNF134 zinc finger protein 134
ZNF211 zinc finger protein 211
ZNF266 zinc finger protein 266
ZXDC ZXD family zinc finger C