nonhomologous end joining complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends. (Gene Ontology, GO_0070419)
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261 proteins co-occuring with the nonhomologous end joining complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PRKDC protein kinase, DNA-activated, catalytic polypeptide 3.6597
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 3.3645
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 3.22045
LIG4 ligase IV, DNA, ATP-dependent 3.17646
ATM ATM serine/threonine kinase 2.30341
RAD51 RAD51 recombinase 2.20818
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 2.09983
H2AFX H2A histone family, member X 1.92508
RAD50 RAD50 homolog (S. cerevisiae) 1.83815
RAD52 RAD52 homolog (S. cerevisiae) 1.83747
DCLRE1C DNA cross-link repair 1C 1.78715
NHEJ1 nonhomologous end-joining factor 1 1.77992
BRCA1 breast cancer 1, early onset 1.76432
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 1.68055
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 1.62945
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 1.61412
LIG3 ligase III, DNA, ATP-dependent 1.53331
POLM polymerase (DNA directed), mu 1.48814
BRCA2 breast cancer 2, early onset 1.44968
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.39016
AICDA activation-induced cytidine deaminase 1.36857
SETMAR SET domain and mariner transposase fusion gene 1.35649
LIG1 ligase I, DNA, ATP-dependent 1.33467
EXO1 exonuclease 1 1.27505
POLL polymerase (DNA directed), lambda 1.24865
TP53 tumor protein p53 1.18543
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 1.17311
CHEK1 checkpoint kinase 1 1.13778
PARP1 poly (ADP-ribose) polymerase 1 1.09493
RAG1 recombination activating gene 1 1.08019
MDC1 mediator of DNA-damage checkpoint 1 1.06448
APLF aprataxin and PNKP like factor 1.0403
RAD51C RAD51 paralog C 1.02979
WRN Werner syndrome, RecQ helicase-like 1.02879
RAG2 recombination activating gene 2 0.962627
ATR ATR serine/threonine kinase 0.909716
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.902281
MSH2 mutS homolog 2 0.897646
PNKP polynucleotide kinase 3'-phosphatase 0.897183
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.843318
FANCD2 Fanconi anemia, complementation group D2 0.836433
RAD54L RAD54-like (S. cerevisiae) 0.825418
ERCC4 excision repair cross-complementation group 4 0.824959
XRCC6BP1 XRCC6 binding protein 1 0.820829
NBAS neuroblastoma amplified sequence 0.803396
RAD18 RAD18 E3 ubiquitin protein ligase 0.791939
DCLRE1A DNA cross-link repair 1A 0.777298
PPP6R2 protein phosphatase 6, regulatory subunit 2 0.773188
NBN nibrin 0.76726
HEATR4 HEAT repeat containing 4 0.751357
RAD54B RAD54 homolog B (S. cerevisiae) 0.751357
CIRBP-AS1 CIRBP antisense RNA 1 0.751357
FAM49A family with sequence similarity 49, member A 0.751357
DEPDC4 DEP domain containing 4 0.751357
TRIM7 tripartite motif containing 7 0.751357
PLSCR2 phospholipid scramblase 2 0.751357
USP42 ubiquitin specific peptidase 42 0.751357
PSORS1C2 psoriasis susceptibility 1 candidate 2 0.751357
ZBED9 zinc finger, BED-type containing 9 0.751357
ZBED8 zinc finger, BED-type containing 8 0.751357
ATXN7L1 ataxin 7-like 1 0.751357
ERCC1 excision repair cross-complementation group 1 0.744122
FBXO24 F-box protein 24 0.725705
PPP6R1 protein phosphatase 6, regulatory subunit 1 0.700423
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.694709
TP53BP1 tumor protein p53 binding protein 1 0.69427
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.67463
TERF2 telomeric repeat binding factor 2 0.666827
RAD51AP1 RAD51 associated protein 1 0.650869
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 0.648291
UIMC1 ubiquitin interaction motif containing 1 0.623504
TDP2 tyrosyl-DNA phosphodiesterase 2 0.622654
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.619255
ERCC2 excision repair cross-complementation group 2 0.617557
PARP3 poly (ADP-ribose) polymerase family, member 3 0.613742
UBA2 ubiquitin-like modifier activating enzyme 2 0.613318
MSL1 male-specific lethal 1 homolog (Drosophila) 0.593072
PARP2 poly (ADP-ribose) polymerase 2 0.592652
TDP1 tyrosyl-DNA phosphodiesterase 1 0.592232
XRRA1 X-ray radiation resistance associated 1 0.583431
MLH1 mutL homolog 1 0.582176
TOP1 topoisomerase (DNA) I 0.566754
FBXL12 F-box and leucine-rich repeat protein 12 0.558457
FBXO28 F-box protein 28 0.532488
BLM Bloom syndrome, RecQ helicase-like 0.531668
GNG10 guanine nucleotide binding protein (G protein), gamma 10 0.516124
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.516124
BANP BTG3 associated nuclear protein 0.502288
UNG uracil-DNA glycosylase 0.49742
PCNA proliferating cell nuclear antigen 0.497015
SBNO2 strawberry notch homolog 2 (Drosophila) 0.493775
POLD2 polymerase (DNA directed), delta 2, accessory subunit 0.493775
EGFR epidermal growth factor receptor 0.487711
SETD3 SET domain containing 3 0.485693
PLP1 proteolipid protein 1 0.484886
BMP8A bone morphogenetic protein 8a 0.474018
UBE2K ubiquitin-conjugating enzyme E2K 0.464798
H2AFY H2A histone family, member Y 0.461998
DCAF11 DDB1 and CUL4 associated factor 11 0.461599
OGG1 8-oxoguanine DNA glycosylase 0.4608
HIST1H4B histone cluster 1, H4b 0.459602
HIST1H4A histone cluster 1, H4a 0.459602
HIST1H4H histone cluster 1, H4h 0.459602
HIST1H4I histone cluster 1, H4i 0.459602
HIST2H4B histone cluster 2, H4b 0.459602
HIST1H4C histone cluster 1, H4c 0.459602
HIST1H4J histone cluster 1, H4j 0.459602
HIST2H4A histone cluster 2, H4a 0.459602
HIST1H4K histone cluster 1, H4k 0.459602
HIST1H4E histone cluster 1, H4e 0.459602
HIST1H4D histone cluster 1, H4d 0.459602
HIST1H4F histone cluster 1, H4f 0.459203
HIST1H4L histone cluster 1, H4l 0.459203
HIST4H4 histone cluster 4, H4 0.459203
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.454418
POLQ polymerase (DNA directed), theta 0.450438
BCR breakpoint cluster region 0.448451
PARP4 poly (ADP-ribose) polymerase family, member 4 0.438542
RNF169 ring finger protein 169 0.434196
RAB9B RAB9B, member RAS oncogene family 0.429859
RNF144A ring finger protein 144A 0.425138
FEN1 flap structure-specific endonuclease 1 0.424745
HIST1H2AD histone cluster 1, H2ad 0.421997
HIST1H2AM histone cluster 1, H2am 0.421997
HIST1H2AJ histone cluster 1, H2aj 0.421997
H2AFJ H2A histone family, member J 0.421997
HIST1H2AH histone cluster 1, H2ah 0.421604
HIST1H2AG histone cluster 1, H2ag 0.420428
H2AFY2 H2A histone family, member Y2 0.41886
HIST1H2AB histone cluster 1, H2ab 0.418077
HIST1H2AE histone cluster 1, H2ae 0.418077
H2AFV H2A histone family, member V 0.417685
H2AFB1 H2A histone family, member B1 0.414946
H2AFB2 H2A histone family, member B2 0.41143
POT1 protection of telomeres 1 0.398975
CELA3A chymotrypsin-like elastase family, member 3A 0.394323
ZNF461 zinc finger protein 461 0.392775
TOP2B topoisomerase (DNA) II beta 180kDa 0.391615
C6ORF15 chromosome 6 open reading frame 15 0.390455
DNASE2 deoxyribonuclease II, lysosomal 0.387751
BARD1 BRCA1 associated RING domain 1 0.385051
TCF19 transcription factor 19 0.378891
TEP1 telomerase-associated protein 1 0.377354
DNTT DNA nucleotidylexotransferase 0.372366
ERCC5 excision repair cross-complementation group 5 0.368919
RAD51B RAD51 paralog B 0.368536
FANCA Fanconi anemia, complementation group A 0.368153
TRIM4 tripartite motif containing 4 0.364713
CCNA2 cyclin A2 0.364331
RBBP8 retinoblastoma binding protein 8 0.360515
MSH4 mutS homolog 4 0.354042
HIST3H2BB histone cluster 3, H2bb 0.346829
HIST2H2BF histone cluster 2, H2bf 0.346829
HIST1H2BH histone cluster 1, H2bh 0.346829
HIST1H2BD histone cluster 1, H2bd 0.346829
HIST1H2BF histone cluster 1, H2bf 0.345314
HIST1H2BC histone cluster 1, H2bc 0.345314
HIST1H2BA histone cluster 1, H2ba 0.344178
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.340773
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.340017
AUTS2 autism susceptibility candidate 2 0.339261
MSH6 mutS homolog 6 0.335487
PARK2 parkin RBR E3 ubiquitin protein ligase 0.334356
XPA xeroderma pigmentosum, complementation group A 0.329084
NPAP1 nuclear pore associated protein 1 0.327205
APTX aprataxin 0.326078
TSN translin 0.324951
RAB11FIP5 RAB11 family interacting protein 5 (class I) 0.324201
CCHCR1 coiled-coil alpha-helical rod protein 1 0.32345
FER fer (fps/fes related) tyrosine kinase 0.321575
HOXD13 homeobox D13 0.318953
CHEK2 checkpoint kinase 2 0.317456
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.317456
FLT3 fms-related tyrosine kinase 3 0.308494
GMCL1 germ cell-less, spermatogenesis associated 1 0.303283
PAPD7 PAP associated domain containing 7 0.301425
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.29994
HUS1 HUS1 checkpoint homolog (S. pombe) 0.295119
MEIG1 meiosis/spermiogenesis associated 1 0.290308
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.287721
SUB1 SUB1 homolog (S. cerevisiae) 0.287352
VCX3B variable charge, X-linked 3B 0.281453
VCX2 variable charge, X-linked 2 0.281453
VCX variable charge, X-linked 0.281453
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 0.278509
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.272633
MSH5 mutS homolog 5 0.270068
XPC xeroderma pigmentosum, complementation group C 0.267505
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.266408
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.262025
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.26166
SMC6 structural maintenance of chromosomes 6 0.260931
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.251114
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.249664
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 0.249664
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 0.249302
H3F3A H3 histone, family 3A 0.247854
H3F3B H3 histone, family 3B (H3.3B) 0.247854
TFIP11 tuftelin interacting protein 11 0.247854
VCX3A variable charge, X-linked 3A 0.24713
NIT2 nitrilase family, member 2 0.243879
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 0.243158
FBXL19 F-box and leucine-rich repeat protein 19 0.242797
FANCC Fanconi anemia, complementation group C 0.242797
CCNA1 cyclin A1 0.238478
TRIM3 tripartite motif containing 3 0.23776
MIDN midnolin 0.233459
HDAC9 histone deacetylase 9 0.229888
HIST2H2AC histone cluster 2, H2ac 0.229176
HIST2H2AA3 histone cluster 2, H2aa3 0.228819
HIST2H2AA4 histone cluster 2, H2aa4 0.228819
CDKN2A cyclin-dependent kinase inhibitor 2A 0.225622
SETD8 SET domain containing (lysine methyltransferase) 8 0.225267
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.222436
ASXL1 additional sex combs like transcriptional regulator 1 0.219617
MVP major vault protein 0.218212
PSMC3IP PSMC3 interacting protein 0.217861
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.217861
UBE2N ubiquitin-conjugating enzyme E2N 0.216111
KDM4D lysine (K)-specific demethylase 4D 0.214366
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.213322
RING1 ring finger protein 1 0.213322
PTCH1 patched 1 0.212627
MIR100 microRNA 100 0.211933
NONO non-POU domain containing, octamer-binding 0.211587
CDK2 cyclin-dependent kinase 2 0.209858
PRKY protein kinase, Y-linked, pseudogene 0.208137
PRKX protein kinase, X-linked 0.207794
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.206082
CCNO cyclin O 0.206082
ISPD isoprenoid synthase domain containing 0.205059
RAD9A RAD9 homolog A (S. pombe) 0.204039
AVEN apoptosis, caspase activation inhibitor 0.201672
ZNF350 zinc finger protein 350 0.198658
EYA4 EYA transcriptional coactivator and phosphatase 4 0.198658
WDR48 WD repeat domain 48 0.195025
IARS isoleucyl-tRNA synthetase 0.192423
GRHL1 grainyhead-like 1 (Drosophila) 0.1921
PPP1R12C protein phosphatase 1, regulatory subunit 12C 0.1921
NEIL2 nei endonuclease VIII-like 2 (E. coli) 0.189539
ERCC3 excision repair cross-complementation group 3 0.18702
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.18702
KAT5 K(lysine) acetyltransferase 5 0.184853
TENM4 teneurin transmembrane protein 4 0.182422
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 0.179459
SPO11 SPO11 meiotic protein covalently bound to DSB 0.175466
ECH1 enoyl CoA hydratase 1, peroxisomal 0.175188
UVRAG UV radiation resistance associated 0.174911
IGF1R insulin-like growth factor 1 receptor 0.173814
TREX2 three prime repair exonuclease 2 0.170888
RECQL4 RecQ protein-like 4 0.165463
RAD23B RAD23 homolog B (S. cerevisiae) 0.165
TRIM28 tripartite motif containing 28 0.163865
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.163865
PPP4C protein phosphatase 4, catalytic subunit 0.16342
RNF4 ring finger protein 4 0.16233
TRIP13 thyroid hormone receptor interactor 13 0.16233
PMP22 peripheral myelin protein 22 0.160863
PIF1 PIF1 5'-to-3' DNA helicase 0.159462
BCCIP BRCA2 and CDKN1A interacting protein 0.159074
FIP1L1 factor interacting with PAPOLA and CPSF1 0.158882