nlrp3 inflammasome complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. (Gene Ontology, GO_0072559)
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97 proteins co-occuring with the nlrp3 inflammasome complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
NLRP3 NLR family, pyrin domain containing 3 4.28729
CARD17 caspase recruitment domain family, member 17 3.41247
MEFV Mediterranean fever 2.60936
CARD8 caspase recruitment domain family, member 8 2.07287
NLRC4 NLR family, CARD domain containing 4 1.91187
PYCARD PYD and CARD domain containing 1.75403
NLRP1 NLR family, pyrin domain containing 1 1.71373
AIM2 absent in melanoma 2 1.62649
IL1B interleukin 1, beta 1.5891
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 1.51074
TXNIP thioredoxin interacting protein 1.43387
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.31412
IL1RN interleukin 1 receptor antagonist 1.30497
CTSB cathepsin B 1.28729
MYD88 myeloid differentiation primary response 88 1.25653
TLR2 toll-like receptor 2 1.11531
IL18 interleukin 18 1.03729
TLR4 toll-like receptor 4 1.03529
OR2B11 olfactory receptor, family 2, subfamily B, member 11 0.966956
IL1R1 interleukin 1 receptor, type I 0.946382
SYK spleen tyrosine kinase 0.934072
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 0.913443
NLRP6 NLR family, pyrin domain containing 6 0.909251
LRRC3 leucine rich repeat containing 3 0.796979
PYDC1 PYD (pyrin domain) containing 1 0.787817
CARD9 caspase recruitment domain family, member 9 0.768171
NOD2 nucleotide-binding oligomerization domain containing 2 0.767715
NLRP2 NLR family, pyrin domain containing 2 0.740515
MIR223 microRNA 223 0.705714
ESX1 ESX homeobox 1 0.697344
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.6638
TLR9 toll-like receptor 9 0.652159
MLKL mixed lineage kinase domain-like 0.641429
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.602752
MAVS mitochondrial antiviral signaling protein 0.583849
NOD1 nucleotide-binding oligomerization domain containing 1 0.568416
CLEC5A C-type lectin domain family 5, member A 0.555559
NSD1 nuclear receptor binding SET domain protein 1 0.539472
CCL7 chemokine (C-C motif) ligand 7 0.538649
HMGB1 high mobility group box 1 0.518981
GBP5 guanylate binding protein 5 0.517756
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.516532
RIPK3 receptor-interacting serine-threonine kinase 3 0.50635
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.479245
NLRP10 NLR family, pyrin domain containing 10 0.472412
TLR6 toll-like receptor 6 0.453621
HCAR1 hydroxycarboxylic acid receptor 1 0.448451
TREM1 triggering receptor expressed on myeloid cells 1 0.428284
NLRP12 NLR family, pyrin domain containing 12 0.423567
IAPP islet amyloid polypeptide 0.393549
TRIM33 tripartite motif containing 33 0.381969
PANX1 pannexin 1 0.370833
NAIP NLR family, apoptosis inhibitory protein 0.368536
TLR1 toll-like receptor 1 0.362804
FAM188A family with sequence similarity 188, member A 0.343421
MVK mevalonate kinase 0.338884
NLRP5 NLR family, pyrin domain containing 5 0.338506
CLEC6A C-type lectin domain family 6, member A 0.328332
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.328332
TLR7 toll-like receptor 7 0.294007
FSTL1 follistatin-like 1 0.281085
DAP death-associated protein 0.274468
TSLP thymic stromal lymphopoietin 0.26239
CRLF2 cytokine receptor-like factor 2 0.254017
SIRT2 sirtuin 2 0.253291
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 0.251476
CLEC4E C-type lectin domain family 4, member E 0.249302
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.24713
NLRP7 NLR family, pyrin domain containing 7 0.246046
IL1RL1 interleukin 1 receptor-like 1 0.239197
IL18BP interleukin 18 binding protein 0.229532
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.229176
GPRC6A G protein-coupled receptor, class C, group 6, member A 0.228108
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 0.225267
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.22385
CTBS chitobiase, di-N-acetyl- 0.22173
TLR8 toll-like receptor 8 0.221378
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 0.216111
IRAK1 interleukin-1 receptor-associated kinase 1 0.215063
IL1A interleukin 1, alpha 0.214366
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 0.214017
TRIB1 tribbles pseudokinase 1 0.211933
CCL2 chemokine (C-C motif) ligand 2 0.207794
CYBB cytochrome b-245, beta polypeptide 0.20574
ASCC3 activating signal cointegrator 1 complex subunit 3 0.205059
UMOD uromodulin 0.202684
PGAM5 phosphoglycerate mutase family member 5 0.201672
CD4 CD4 molecule 0.195353
HMOX1 heme oxygenase 1 0.191456
S100A8 S100 calcium binding protein A8 0.188905
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 0.183025
FFAR4 free fatty acid receptor 4 0.18093
IL13 interleukin 13 0.17687
CXCL3 chemokine (C-X-C motif) ligand 3 0.172735
CAMP cathelicidin antimicrobial peptide 0.164315
DICER1 dicer 1, ribonuclease type III 0.157943
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.157218