nlrp3 inflammasome complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. (Gene Ontology, GO_0072559)
Similar Terms
Downloads & Tools

Genes

5 proteins localized to the nlrp3 inflammasome complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PYCARD PYD and CARD domain containing 0.663342
CARD8 caspase recruitment domain family, member 8 0.663342
NLRP3 NLR family, pyrin domain containing 3 0.663342
CARD17 caspase recruitment domain family, member 17 0.663342
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.098109