neuron spine Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. (Gene Ontology, GO_0044309)
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Genes

136 proteins localized to the neuron spine cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
FRMPD4 FERM and PDZ domain containing 4 0.663342
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.663342
NLGN4X neuroligin 4, X-linked 0.663342
DNM2 dynamin 2 0.663342
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.663342
HOMER2 homer scaffolding protein 2 0.663342
SYNPO synaptopodin 0.663342
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.663342
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 0.663342
NCS1 neuronal calcium sensor 1 0.663342
APP amyloid beta (A4) precursor protein 0.663342
CABP1 calcium binding protein 1 0.663342
DTNBP1 dystrobrevin binding protein 1 0.663342
MPDZ multiple PDZ domain protein 0.663342
ACTN2 actinin, alpha 2 0.663342
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.663342
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.663342
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.663342
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.663342
STRN striatin, calmodulin binding protein 0.237908
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.237908
TENM2 teneurin transmembrane protein 2 0.237908
SHISA9 shisa family member 9 0.237908
RGS14 regulator of G-protein signaling 14 0.237908
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.237908
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.237908
CNIH2 cornichon family AMPA receptor auxiliary protein 2 0.237908
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.237908
DLG4 discs, large homolog 4 (Drosophila) 0.237908
GPER1 G protein-coupled estrogen receptor 1 0.237908
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.237908
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.237908
NEURL1 neuralized E3 ubiquitin protein ligase 1 0.237908
PDLIM5 PDZ and LIM domain 5 0.237908
SYNDIG1 synapse differentiation inducing 1 0.237908
PTPRO protein tyrosine phosphatase, receptor type, O 0.237908
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 0.237908
SRCIN1 SRC kinase signaling inhibitor 1 0.237908
CDK5 cyclin-dependent kinase 5 0.237908
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.237908
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 0.237908
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.237908
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.237908
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 0.237908
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.237908
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.237908
DNM3 dynamin 3 0.237908
AXIN2 axin 2 0.098109
AXIN1 axin 1 0.098109
PTK2B protein tyrosine kinase 2 beta 0.098109
MTMR2 myotubularin related protein 2 0.098109
GRID2 glutamate receptor, ionotropic, delta 2 0.098109
GRM5 glutamate receptor, metabotropic 5 0.098109
GRM1 glutamate receptor, metabotropic 1 0.098109
CRIPT cysteine-rich PDZ-binding protein 0.098109
GIPC1 GIPC PDZ domain containing family, member 1 0.098109
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.098109
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.098109
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.098109
LRP4 low density lipoprotein receptor-related protein 4 0.098109
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.098109
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.098109
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.03318
LYN LYN proto-oncogene, Src family tyrosine kinase 0.03318
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.03318
FYN FYN proto-oncogene, Src family tyrosine kinase 0.03318
HOMER3 homer scaffolding protein 3 0.03318
LRRC4 leucine rich repeat containing 4 0.03318
FBXO45 F-box protein 45 0.03318
PTEN phosphatase and tensin homolog 0.03318
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.03318
EPHA4 EPH receptor A4 0.03318
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.03318
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.03318
SEZ6 seizure related 6 homolog (mouse) 0.03318
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.03318
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 0.03318
MYH10 myosin, heavy chain 10, non-muscle 0.03318
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 0.03318
ITGA8 integrin, alpha 8 0.03318
ADD1 adducin 1 (alpha) 0.03318
PTCH1 patched 1 0.03318
LPAR1 lysophosphatidic acid receptor 1 0.03318
IFNGR1 interferon gamma receptor 1 0.03318
ADAM10 ADAM metallopeptidase domain 10 0.03318
LAMA2 laminin, alpha 2 0.03318
PLCB4 phospholipase C, beta 4 0.03318
ACTN1 actinin, alpha 1 0.03318
ASIC2 acid sensing (proton gated) ion channel 2 0.03318
KLHL17 kelch-like family member 17 0.03318
FMR1 fragile X mental retardation 1 0.03318
SOS1 son of sevenless homolog 1 (Drosophila) 0.03318
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.03318
LZTS1 leucine zipper, putative tumor suppressor 1 0.03318
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.03318
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.03318
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.03318
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.03318
RAB8A RAB8A, member RAS oncogene family 0.03318
CANX calnexin 0.03318
OPHN1 oligophrenin 1 0.03318
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.03318
PALMD palmdelphin 0.03318
RGS10 regulator of G-protein signaling 10 0.03318
ADORA1 adenosine A1 receptor 0.03318
GRIK5 glutamate receptor, ionotropic, kainate 5 0.03318
GRIK2 glutamate receptor, ionotropic, kainate 2 0.03318
GSK3B glycogen synthase kinase 3 beta 0.03318
ITPKA inositol-trisphosphate 3-kinase A 0.03318
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.03318
DLG1 discs, large homolog 1 (Drosophila) 0.03318
ARRB2 arrestin, beta 2 0.03318
ARRB1 arrestin, beta 1 0.03318
CHRM1 cholinergic receptor, muscarinic 1 0.03318
ACTB actin, beta 0.03318
PALM paralemmin 0.03318
GRM3 glutamate receptor, metabotropic 3 0.03318
MYD88 myeloid differentiation primary response 88 0.03318
FBXO2 F-box protein 2 0.03318
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.03318
SHARPIN SHANK-associated RH domain interactor 0.03318
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 0.03318
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.03318
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.03318
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 0.03318
EPS8 epidermal growth factor receptor pathway substrate 8 0.03318
RAB8B RAB8B, member RAS oncogene family 0.03318
EEA1 early endosome antigen 1 0.03318
DRD2 dopamine receptor D2 0.03318
DRD4 dopamine receptor D4 0.03318
MYL7 myosin, light chain 7, regulatory 0.03318
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.03318
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.03318
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.03318
DBNL drebrin-like 0.03318
CTNND1 catenin (cadherin-associated protein), delta 1 0.03318