neural tube defects Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description any structural anomaly of or development of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord) (Mammalian Phenotype Ontology, MP_0002151)
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Genes

33 genes associated with the disease neural tube defects in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BHMT betaine--homocysteine S-methyltransferase
BMP4 bone morphogenetic protein 4
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CD320 CD320 molecule
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CXCL6 chemokine (C-X-C motif) ligand 6
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DHFR dihydrofolate reductase
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
NOG noggin
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
RFC1 replication factor C (activator 1) 1, 145kDa
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC19A1 solute carrier family 19 (folate transporter), member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCN2 transcobalamin II
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VANGL1 VANGL planar cell polarity protein 1
VANGL2 VANGL planar cell polarity protein 2
ZIC2 Zic family member 2