neoplasm of the large intestine Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description The presence of a neoplasm of the large intestine. (Human Phenotype Ontology, HP_0100834)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0100834
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Genes

246 genes associated with the neoplasm of the large intestine phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
SMAD7 SMAD family member 7 2.16902
COLCA2 colorectal cancer associated 2 1.5834
C11ORF53 chromosome 11 open reading frame 53 1.54341
LAMA5 laminin, alpha 5 1.41863
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 1.38847
RHPN2 rhophilin, Rho GTPase binding protein 2 1.28282
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.25845
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.24751
MYNN myoneurin 1.19958
C1ORF21 chromosome 1 open reading frame 21 1.17498
CCND2 cyclin D2 1.17192
LAMC1 laminin, gamma 1 (formerly LAMB2) 1.15743
GREM1 gremlin 1, DAN family BMP antagonist 1.14684
TBX3 T-box 3 1.09906
HSPA12A heat shock 70kDa protein 12A 1.05066
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.99914
FRMD4A FERM domain containing 4A 0.9776
BBX bobby sox homolog (Drosophila) 0.971375
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.969142
TPH2 tryptophan hydroxylase 2 0.969142
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.954778
SYNJ2 synaptojanin 2 0.942765
LINC00303 long intergenic non-protein coding RNA 303 0.913571
RUFY4 RUN and FYVE domain containing 4 0.891813
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.885753
COL5A1 collagen, type V, alpha 1 0.881868
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.881868
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.862558
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.849438
FER1L5 fer-1-like family member 5 0.84498
XDH xanthine dehydrogenase 0.844346
FAM49B family with sequence similarity 49, member B 0.844241
CXCR2 chemokine (C-X-C motif) receptor 2 0.841148
C11ORF73 chromosome 11 open reading frame 73 0.835282
MECOM MDS1 and EVI1 complex locus 0.828053
RIC1 RAB6A GEF complex partner 1 0.827192
SMTNL2 smoothelin-like 2 0.798387
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 0.786
KCNIP1 Kv channel interacting protein 1 0.767198
TDRD9 tudor domain containing 9 0.74997
EDAR ectodysplasin A receptor 0.747666
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 0.680832
RSU1 Ras suppressor protein 1 0.659752
LIFR leukemia inhibitory factor receptor alpha 0.657238
ZEB1 zinc finger E-box binding homeobox 1 0.656005
PTPRT protein tyrosine phosphatase, receptor type, T 0.642222
RIT2 Ras-like without CAAX 2 0.630049
CNTN5 contactin 5 0.628153
ATXN1 ataxin 1 0.618783
KIAA1549L KIAA1549-like 0.611045
CAPN13 calpain 13 0.588613
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 0.578018
UTRN utrophin 0.572823
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.572823
TTN titin 0.572823
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.572823
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 0.53407
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1 0.522136
VWA3B von Willebrand factor A domain containing 3B 0.522136
TNC tenascin C 0.522136
CCDC88C coiled-coil domain containing 88C 0.522136
MYPN myopalladin 0.522136
MYO3A myosin IIIA 0.50495
MDM1 Mdm1 nuclear protein homolog (mouse) 0.498792
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 0.482262
MLPH melanophilin 0.481126
NCKAP5 NCK-associated protein 5 0.481126
LINS lines homolog (Drosophila) 0.466578
NRDE2 NRDE-2, necessary for RNA interference, domain containing 0.466578
DFNB31 deafness, autosomal recessive 31 0.443881
ARHGAP18 Rho GTPase activating protein 18 0.443881
C15ORF32 chromosome 15 open reading frame 32 0.443881
ISX intestine-specific homeobox 0.429005
ANXA11 annexin A11 0.429005
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.413807
CALCR calcitonin receptor 0.407192
MALRD1 MAM and LDL receptor class A domain containing 1 0.406588
SLC51A solute carrier family 51, alpha subunit 0.405515
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.404199
ZFAND4 zinc finger, AN1-type domain 4 0.403265
CNTNAP2 contactin associated protein-like 2 0.403073
SMAD6 SMAD family member 6 0.402177
APP amyloid beta (A4) precursor protein 0.401355
PTPRJ protein tyrosine phosphatase, receptor type, J 0.401355
TRAPPC9 trafficking protein particle complex 9 0.401355
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.401355
KLHL32 kelch-like family member 32 0.401355
FRMD5 FERM domain containing 5 0.396463
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.395974
MAP2 microtubule-associated protein 2 0.395511
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.395511
RYR2 ryanodine receptor 2 (cardiac) 0.395511
AIG1 androgen-induced 1 0.395511
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.395511
C4ORF45 chromosome 4 open reading frame 45 0.395511
C20ORF196 chromosome 20 open reading frame 196 0.395511
EGFR epidermal growth factor receptor 0.395511
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.395511
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.395511
CHD9 chromodomain helicase DNA binding protein 9 0.391503
NRXN3 neurexin 3 0.391503
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.391503
ZNF385D zinc finger protein 385D 0.391503
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.391503
TPK1 thiamin pyrophosphokinase 1 0.391503
ERBB4 erb-b2 receptor tyrosine kinase 4 0.391503
PXDNL peroxidasin-like 0.391503
BMPR1B bone morphogenetic protein receptor, type IB 0.391503
ELMO1 engulfment and cell motility 1 0.391503
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.391503
ADAMTSL3 ADAMTS-like 3 0.391503
PCDH9 protocadherin 9 0.391503
USP45 ubiquitin specific peptidase 45 0.38925
PAX2 paired box 2 0.388964
FAM207A family with sequence similarity 207, member A 0.388686
LPA lipoprotein, Lp(a) 0.388393
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.388393
AOX2P aldehyde oxidase 2 pseudogene 0.388393
CCDC67 coiled-coil domain containing 67 0.388393
CADM1 cell adhesion molecule 1 0.388393
FGF12 fibroblast growth factor 12 0.388393
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.388393
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.388393
NRG3 neuregulin 3 0.388393
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.388393
ALPK3 alpha-kinase 3 0.388393
PTPRD protein tyrosine phosphatase, receptor type, D 0.388393
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.388393
DCLK1 doublecortin-like kinase 1 0.385578
MEMO1 mediator of cell motility 1 0.385578
ARMC8 armadillo repeat containing 8 0.385578
LINC00540 long intergenic non-protein coding RNA 540 0.385578
SOX5 SRY (sex determining region Y)-box 5 0.385578
TFEC transcription factor EC 0.383291
NGEF neuronal guanine nucleotide exchange factor 0.383291
EIF3E eukaryotic translation initiation factor 3, subunit E 0.383291
LDB2 LIM domain binding 2 0.383291
COL13A1 collagen, type XIII, alpha 1 0.383291
SEZ6L seizure related 6 homolog (mouse)-like 0.383291
ESRRG estrogen-related receptor gamma 0.383291
C6ORF89 chromosome 6 open reading frame 89 0.383291
SRD5A3 steroid 5 alpha-reductase 3 0.383291
FBLN1 fibulin 1 0.383291
ASS1 argininosuccinate synthase 1 0.383291
TBC1D22A TBC1 domain family, member 22A 0.381664
PRR16 proline rich 16 0.381276
LIMCH1 LIM and calponin homology domains 1 0.381276
DOPEY1 dopey family member 1 0.381276
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 0.381276
KIAA1217 KIAA1217 0.381276
KIF13B kinesin family member 13B 0.381276
MACROD1 MACRO domain containing 1 0.381276
UMODL1 uromodulin-like 1 0.379492
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.379492
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.379492
PCDH15 protocadherin-related 15 0.379492
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.379492
AKNAD1 AKNA domain containing 1 0.379492
SCHIP1 schwannomin interacting protein 1 0.379492
CADM2 cell adhesion molecule 2 0.379492
FAM71F1 family with sequence similarity 71, member F1 0.379492
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 0.379492
LOC339862 uncharacterized LOC339862 0.379492
LUZP2 leucine zipper protein 2 0.377925
LAMA2 laminin, alpha 2 0.377925
ASTN2 astrotactin 2 0.377925
ASPA aspartoacylase 0.377925
SBF2 SET binding factor 2 0.377925
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.377925
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.377925
IQCJ IQ motif containing J 0.377925
LOC728755 uncharacterized LOC728755 0.377925
ELOVL6 ELOVL fatty acid elongase 6 0.377925
NTM neurotrimin 0.377925
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.377925
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.377925
GLIS3 GLIS family zinc finger 3 0.377925
TMEM132D transmembrane protein 132D 0.377925
PDZRN3 PDZ domain containing ring finger 3 0.376528
TOX thymocyte selection-associated high mobility group box 0.376528
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.376528
ARHGAP15 Rho GTPase activating protein 15 0.376528
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.376528
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.376528
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.376528
TMEM165 transmembrane protein 165 0.376528
KIAA1456 KIAA1456 0.376528
LYN LYN proto-oncogene, Src family tyrosine kinase 0.376528
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.376528
CFAP61 cilia and flagella associated protein 61 0.376528
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.376528
SAMD3 sterile alpha motif domain containing 3 0.376528
CLOCK clock circadian regulator 0.376528
FAM111B family with sequence similarity 111, member B 0.376528
CCDC174 coiled-coil domain containing 174 0.376528
RELN reelin 0.376528
KIF16B kinesin family member 16B 0.376528
MACROD2 MACRO domain containing 2 0.376528
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.376528
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.376528
SCN3A sodium channel, voltage gated, type III alpha subunit 0.376528
CSPP1 centrosome and spindle pole associated protein 1 0.376528
NXPH1 neurexophilin 1 0.376528
MAN2B2 mannosidase, alpha, class 2B, member 2 0.376528
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.376528
C6ORF7 chromosome 6 open reading frame 7 0.376528
IRAK3 interleukin-1 receptor-associated kinase 3 0.376528
PADI3 peptidyl arginine deiminase, type III 0.376528
PARD3B par-3 family cell polarity regulator beta 0.376528
C4ORF22 chromosome 4 open reading frame 22 0.376528
SLIT1 slit homolog 1 (Drosophila) 0.376528
SNAP25 synaptosomal-associated protein, 25kDa 0.376528
CD38 CD38 molecule 0.376528
CTIF CBP80/20-dependent translation initiation factor 0.376528
FGF6 fibroblast growth factor 6 0.376528
PELP1 proline, glutamate and leucine rich protein 1 0.376528
FAM189A1 family with sequence similarity 189, member A1 0.376528
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.376528
NUP160 nucleoporin 160kDa 0.376528
CLIC5 chloride intracellular channel 5 0.376528
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.376528
THADA thyroid adenoma associated 0.376528
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.376528
SGK1 serum/glucocorticoid regulated kinase 1 0.376528
LINC00578 long intergenic non-protein coding RNA 578 0.376528
FRMD6 FERM domain containing 6 0.376528
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.376528
SPTBN1 spectrin, beta, non-erythrocytic 1 0.376528
MINOS1-NBL1 MINOS1-NBL1 readthrough 0.376528
LRP5L low density lipoprotein receptor-related protein 5-like 0.376528
FAM163A family with sequence similarity 163, member A 0.376528
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.376528
OSBPL1A oxysterol binding protein-like 1A 0.376528
DCAF4 DDB1 and CUL4 associated factor 4 0.376528
PDCL2 phosducin-like 2 0.369661
CHD2 chromodomain helicase DNA binding protein 2 0.368924
IKBIP IKBKB interacting protein 0.367568
APAF1 apoptotic peptidase activating factor 1 0.367568
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.365776
ZFYVE1 zinc finger, FYVE domain containing 1 0.365232
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.364711
TCF3 transcription factor 3 0.363702
CACHD1 cache domain containing 1 0.361805
CPM carboxypeptidase M 0.361805
NBEA neurobeachin 0.357318
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.355992