neoplasm by histology Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Neoplasm categorized according to type of histological abnormality. (Human Phenotype Ontology, HP_0011792)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0011792
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Genes

233 genes associated with the neoplasm by histology phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
CDK10 cyclin-dependent kinase 10 0.468836
DLG2 discs, large homolog 2 (Drosophila) 0.394223
BARD1 BRCA1 associated RING domain 1 0.384433
TERT telomerase reverse transcriptase 0.381888
EGR2 early growth response 2 0.379572
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.377267
MGMT O-6-methylguanine-DNA methyltransferase 0.376528
CDKN2B-AS1 CDKN2B antisense RNA 1 0.371313
LMO1 LIM domain only 1 (rhombotin 1) 0.371313
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.369136
PIGU phosphatidylinositol glycan anchor biosynthesis, class U 0.369081
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.363975
TYR tyrosinase 0.359165
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 0.346892
RTEL1 regulator of telomere elongation helicase 1 0.339741
FTO fat mass and obesity associated 0.338502
TCN2 transcobalamin II 0.337544
NCOA6 nuclear receptor coactivator 6 0.329525
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.329298
PHLDB1 pleckstrin homology-like domain, family B, member 1 0.326881
SPATA33 spermatogenesis associated 33 0.324445
DEF8 differentially expressed in FDCP 8 homolog (mouse) 0.322508
BPIFA3 BPI fold containing family A, member 3 0.316795
AFG3L1P AFG3-like AAA ATPase 1, pseudogene 0.314856
ALS2CR12 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 0.309998
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.309281
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.309016
LRP1B low density lipoprotein receptor-related protein 1B 0.307072
PPA2 pyrophosphatase (inorganic) 2 0.304624
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.304591
PARD3B par-3 family cell polarity regulator beta 0.30433
STK4 serine/threonine kinase 4 0.302689
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.302386
MX2 MX dynamin-like GTPase 2 0.301722
ATM ATM serine/threonine kinase 0.301722
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.300929
KIF26B kinesin family member 26B 0.295334
MTAP methylthioadenosine phosphorylase 0.294727
DGKI diacylglycerol kinase, iota 0.294224
GRM4 glutamate receptor, metabotropic 4 0.293634
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.293453
LIN28B lin-28 homolog B (C. elegans) 0.291815
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.283626
CLPTM1L CLPTM1-like 0.282188
SMYD3 SET and MYND domain containing 3 0.280998
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.280351
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.275483
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 0.274248
EGFR epidermal growth factor receptor 0.274195
CDK5RAP1 CDK5 regulatory subunit associated protein 1 0.273256
PARP1 poly (ADP-ribose) polymerase 1 0.271852
C1ORF127 chromosome 1 open reading frame 127 0.271648
PCSK9 proprotein convertase subtilisin/kexin type 9 0.270874
DBT dihydrolipoamide branched chain transacylase E2 0.266856
PHF20 PHD finger protein 20 0.26561
SLC45A2 solute carrier family 45, member 2 0.263857
ANKRD11 ankyrin repeat domain 11 0.258622
RSRC1 arginine/serine-rich coiled-coil 1 0.258288
TRAF5 TNF receptor-associated factor 5 0.255741
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.254439
CPZ carboxypeptidase Z 0.253325
XPO4 exportin 4 0.252915
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 0.251921
ACOT11 acyl-CoA thioesterase 11 0.249813
SSBP2 single-stranded DNA binding protein 2 0.247235
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.247235
IKZF1 IKAROS family zinc finger 1 (Ikaros) 0.243478
ZNF276 zinc finger protein 276 0.243478
DPEP1 dipeptidase 1 (renal) 0.242805
FANCA Fanconi anemia, complementation group A 0.241836
ANXA9 annexin A9 0.239689
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.239163
MIR205HG MIR205 host gene 0.235697
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.234984
CALCOCO2 calcium binding and coiled-coil domain 2 0.231984
IL31RA interleukin 31 receptor A 0.230341
KAZN kazrin, periplakin interacting protein 0.230341
DNAH7 dynein, axonemal, heavy chain 7 0.230254
LRRC69 leucine rich repeat containing 69 0.229537
CSMD1 CUB and Sushi multiple domains 1 0.228845
TIAM1 T-cell lymphoma invasion and metastasis 1 0.228673
CPNE7 copine VII 0.228274
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 0.228233
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.227828
USP10 ubiquitin specific peptidase 10 0.227828
KAT2B K(lysine) acetyltransferase 2B 0.225995
FAM208B family with sequence similarity 208, member B 0.224413
LINC00189 long intergenic non-protein coding RNA 189 0.224413
DCC DCC netrin 1 receptor 0.223022
RALY RALY heterogeneous nuclear ribonucleoprotein 0.222996
CCDC23 coiled-coil domain containing 23 0.222019
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.222019
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.221097
RLF rearranged L-myc fusion 0.220663
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.220663
MORC3 MORC family CW-type zinc finger 3 0.219742
OGFRL1 opioid growth factor receptor-like 1 0.219167
FRMD8 FERM domain containing 8 0.218981
PRMT8 protein arginine methyltransferase 8 0.218799
COTL1 coactosin-like F-actin binding protein 1 0.218097
PCSK6 proprotein convertase subtilisin/kexin type 6 0.216888
IQSEC3 IQ motif and Sec7 domain 3 0.215589
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.215386
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.215253
STIM2 stromal interaction molecule 2 0.214424
PLD5 phospholipase D family, member 5 0.214302
DOCK8 dedicator of cytokinesis 8 0.214181
SLC39A10 solute carrier family 39 (zinc transporter), member 10 0.213826
MAN1B1 mannosidase, alpha, class 1B, member 1 0.213767
SAFB2 scaffold attachment factor B2 0.21371
SHROOM3 shroom family member 3 0.213481
LOC146513 uncharacterized LOC146513 0.213481
SOX6 SRY (sex determining region Y)-box 6 0.213147
ZMYND15 zinc finger, MYND-type containing 15 0.212823
TTYH1 tweety family member 1 0.211659
HIAT1 hippocampus abundant transcript 1 0.211611
LOC100507195 uncharacterized LOC100507195 0.211468
DRD1 dopamine receptor D1 0.211189
RPS7P5 ribosomal protein S7 pseudogene 5 0.210826
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 0.210693
SPHKAP SPHK1 interactor, AKAP domain containing 0.210134
BTNL2 butyrophilin-like 2 0.209968
JARID2 jumonji, AT rich interactive domain 2 0.209845
NTN1 netrin 1 0.209642
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 0.209133
TOX2 TOX high mobility group box family member 2 0.208943
PEX14 peroxisomal biogenesis factor 14 0.208719
SASS6 spindle assembly 6 homolog (C. elegans) 0.208682
DOCK1 dedicator of cytokinesis 1 0.208572
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.208214
CLIP3 CAP-GLY domain containing linker protein 3 0.207935
NXPH1 neurexophilin 1 0.207901
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.20763
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.206281
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.206281
PNLIP pancreatic lipase 0.206173
DNAH9 dynein, axonemal, heavy chain 9 0.206137
SCARB1 scavenger receptor class B, member 1 0.20603
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.205923
PTPRG protein tyrosine phosphatase, receptor type, G 0.205853
ZFAT zinc finger and AT hook domain containing 0.205818
ELMO1 engulfment and cell motility 1 0.205783
E2F1 E2F transcription factor 1 0.205438
PTPRO protein tyrosine phosphatase, receptor type, O 0.205002
GLCCI1 glucocorticoid induced 1 0.205002
PAQR5 progestin and adipoQ receptor family member V 0.204936
GPA33 glycoprotein A33 (transmembrane) 0.204904
ERO1L ERO1-like (S. cerevisiae) 0.20458
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.204517
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.204453
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.20411
SP100 SP100 nuclear antigen 0.203926
ATF6 activating transcription factor 6 0.203926
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.203508
GRM7 glutamate receptor, metabotropic 7 0.203449
NRSN1 neurensin 1 0.203303
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.203274
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.203159
GTSF1 gametocyte specific factor 1 0.203016
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.202819
IRF4 interferon regulatory factor 4 0.202736
FAM13A family with sequence similarity 13, member A 0.202515
DPH6 diphthamine biosynthesis 6 0.202352
TOX thymocyte selection-associated high mobility group box 0.202272
FOXP1 forkhead box P1 0.201542
MRPL23 mitochondrial ribosomal protein L23 0.201542
SH3YL1 SH3 and SYLF domain containing 1 0.201466
OR2M7 olfactory receptor, family 2, subfamily M, member 7 0.200922
ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene 0.200682
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense 0.200611
MAMDC2 MAM domain containing 2 0.200541
LOC285768 uncharacterized LOC285768 0.200308
LEPR leptin receptor 0.200216
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.199921
SDK1 sidekick cell adhesion molecule 1 0.199831
KCTD10 potassium channel tetramerization domain containing 10 0.199809
MED13L mediator complex subunit 13-like 0.199655
KCNK10 potassium channel, two pore domain subfamily K, member 10 0.199244
KIF16B kinesin family member 16B 0.199222
HDAC4 histone deacetylase 4 0.199053
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.198949
PCDH15 protocadherin-related 15 0.1986
ANKAR ankyrin and armadillo repeat containing 0.198499
SLC38A9 solute carrier family 38, member 9 0.19822
UBE3B ubiquitin protein ligase E3B 0.198044
ARHGAP26 Rho GTPase activating protein 26 0.198025
PARK2 parkin RBR E3 ubiquitin protein ligase 0.197586
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.197549
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.197455
PITPNM3 PITPNM family member 3 0.1974
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.197253
DOCK5 dedicator of cytokinesis 5 0.197143
CDH23 cadherin-related 23 0.19691
LST1 leukocyte specific transcript 1 0.19691
TTLL6 tubulin tyrosine ligase-like family member 6 0.196768
TMEM222 transmembrane protein 222 0.196438
CEP128 centrosomal protein 128kDa 0.196166
SFTA3 surfactant associated 3 0.196149
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.195574
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.19551
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.195462
VWA3B von Willebrand factor A domain containing 3B 0.195462
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.195414
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 0.195335
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.195335
AADACL3 arylacetamide deacetylase-like 3 0.19521
SRBD1 S1 RNA binding domain 1 0.194993
PLSCR3 phospholipid scramblase 3 0.194749
ARID1A AT rich interactive domain 1A (SWI-like) 0.194629
INSC inscuteable homolog (Drosophila) 0.194451
MSRA methionine sulfoxide reductase A 0.194334
EXT1 exostosin glycosyltransferase 1 0.194261
SPP2 secreted phosphoprotein 2, 24kDa 0.194246
LOXHD1 lipoxygenase homology domains 1 0.194203
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.194174
CLEC4M C-type lectin domain family 4, member M 0.194145
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.193988
SLIT3 slit homolog 3 (Drosophila) 0.193889
MVK mevalonate kinase 0.193889
MROH2A maestro heat-like repeat family member 2A 0.193832
RAI1 retinoic acid induced 1 0.193776
CREB5 cAMP responsive element binding protein 5 0.193665
MTUS1 microtubule associated tumor suppressor 1 0.193554
ADGRB3 adhesion G protein-coupled receptor B3 0.193541
SASH1 SAM and SH3 domain containing 1 0.193255
KIFC3 kinesin family member C3 0.193242
ONECUT2 one cut homeobox 2 0.193148
ZC3H3 zinc finger CCCH-type containing 3 0.191164
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.190388
MTSS1 metastasis suppressor 1 0.180909
GPR149 G protein-coupled receptor 149 0.174144
TRAPPC9 trafficking protein particle complex 9 0.162177
RAD50 RAD50 homolog (S. cerevisiae) 0.160387