negative regulation of mapk cascade Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. (Gene Ontology, GO_0043409)
External Link http://amigo.geneontology.org/amigo/term/GO:0043409
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Genes

134 genes participating in the negative regulation of mapk cascade biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADIPOQ adiponectin, C1Q and collagen domain containing
AIDA axin interactor, dorsalization associated
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMBP alpha-1-microglobulin/bikunin precursor
ANKRD26 ankyrin repeat domain 26
APC adenomatous polyposis coli
APOE apolipoprotein E
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
C1QL4 complement component 1, q subcomponent-like 4
C3ORF33 chromosome 3 open reading frame 33
CAV1 caveolin 1, caveolae protein, 22kDa
CAV3 caveolin 3
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase
CD300A CD300a molecule
CNKSR3 CNKSR family member 3
CSK c-src tyrosine kinase
DAB2IP DAB2 interacting protein
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP16 dual specificity phosphatase 16
DUSP18 dual specificity phosphatase 18
DUSP19 dual specificity phosphatase 19
DUSP2 dual specificity phosphatase 2
DUSP21 dual specificity phosphatase 21
DUSP22 dual specificity phosphatase 22
DUSP26 dual specificity phosphatase 26 (putative)
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP8 dual specificity phosphatase 8
DUSP9 dual specificity phosphatase 9
F2RL1 coagulation factor II (thrombin) receptor-like 1
FKTN fukutin
FLCN folliculin
FOXM1 forkhead box M1
FOXO1 forkhead box O1
GBA glucosidase, beta, acid
GPS1 G protein pathway suppressor 1
GPS2 G protein pathway suppressor 2
GSK3B glycogen synthase kinase 3 beta
GSTP1 glutathione S-transferase pi 1
HDAC3 histone deacetylase 3
HIPK3 homeodomain interacting protein kinase 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HYAL2 hyaluronoglucosaminidase 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL1B interleukin 1, beta
INPP5K inositol polyphosphate-5-phosphatase K
IRAK3 interleukin-1 receptor-associated kinase 3
ITCH itchy E3 ubiquitin protein ligase
ITGB1BP1 integrin beta 1 binding protein 1
KLF4 Kruppel-like factor 4 (gut)
LAX1 lymphocyte transmembrane adaptor 1
LEMD2 LEM domain containing 2
LIF leukemia inhibitory factor
LMO3 LIM domain only 3 (rhombotin-like 2)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MARVELD3 MARVEL domain containing 3
MBIP MAP3K12 binding inhibitory protein 1
MECOM MDS1 and EVI1 complex locus
MEN1 multiple endocrine neoplasia I
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOR1 nuclear receptor corepressor 1
NDRG2 NDRG family member 2
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NLRP12 NLR family, pyrin domain containing 12
NLRP6 NLR family, pyrin domain containing 6
NUP62 nucleoporin 62kDa
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAQR3 progestin and adipoQ receptor family member III
PARK2 parkin RBR E3 ubiquitin protein ligase
PBK PDZ binding kinase
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER1 period circadian clock 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PINK1 PTEN induced putative kinase 1
PPEF2 protein phosphatase, EF-hand calcium binding domain 2
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRR protein tyrosine phosphatase, receptor type, R
RANBP9 RAN binding protein 9
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RGS14 regulator of G-protein signaling 14
RGS2 regulator of G-protein signaling 2
RGS3 regulator of G-protein signaling 3
RGS4 regulator of G-protein signaling 4
RNF149 ring finger protein 149
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP5 secreted frizzled-related protein 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRED3 sprouty-related, EVH1 domain containing 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STK38 serine/threonine kinase 38
TAOK3 TAO kinase 3
TBC1D10C TBC1 domain family, member 10C
TLR4 toll-like receptor 4
TNIP1 TNFAIP3 interacting protein 1
TP73 tumor protein p73
TSC2 tuberous sclerosis 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VRK3 vaccinia related kinase 3
WNK2 WNK lysine deficient protein kinase 2
ZMYND11 zinc finger, MYND-type containing 11
ZNF675 zinc finger protein 675