negative cofactor 2 complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. (Gene Ontology, GO_0017054)
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19 proteins co-occuring with the negative cofactor 2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.44436
GTF2B general transcription factor IIB 1.79707
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 1.52766
MED7 mediator complex subunit 7 1.19983
MED10 mediator complex subunit 10 1.15364
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.984393
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 0.960227
CFAP20 cilia and flagella associated protein 20 0.950189
IPO13 importin 13 0.881016
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.804313
TBP TATA box binding protein 0.792854
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.564677
HIST2H2AC histone cluster 2, H2ac 0.429465
HIST2H2AA4 histone cluster 2, H2aa4 0.429072
HIST2H2AA3 histone cluster 2, H2aa3 0.429072
PRC1 protein regulator of cytokinesis 1 0.414555
HMGB1 high mobility group box 1 0.233817
XPO1 exportin 1 0.219617
TOP1 topoisomerase (DNA) I 0.185469