nefopam-2317 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the nefopam-2317 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM22 ADAM metallopeptidase domain 22
AKR1D1 aldo-keto reductase family 1, member D1
ALDOB aldolase B, fructose-bisphosphate
APOC4 apolipoprotein C-IV
APOLD1 apolipoprotein L domain containing 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASB1 ankyrin repeat and SOCS box containing 1
AVIL advillin
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C6 complement component 6
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CD200 CD200 molecule
CD8A CD8a molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPQ carboxypeptidase Q
CRHR2 corticotropin releasing hormone receptor 2
CXXC4 CXXC finger protein 4
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DGCR2 DiGeorge syndrome critical region gene 2
DICER1 dicer 1, ribonuclease type III
DUSP9 dual specificity phosphatase 9
ECE1 endothelin converting enzyme 1
EGFR epidermal growth factor receptor
EGR3 early growth response 3
EPHB2 EPH receptor B2
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
FCAR Fc fragment of IgA receptor
FCMR Fc fragment of IgM receptor
FGFR1 fibroblast growth factor receptor 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GATA2 GATA binding protein 2
GMPR guanosine monophosphate reductase
GRIP2 glutamate receptor interacting protein 2
GSTTP1 glutathione S-transferase theta pseudogene 1
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
GYG2 glycogenin 2
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPSE2 heparanase 2 (inactive)
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRF4 interferon regulatory factor 4
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPKA inositol-trisphosphate 3-kinase A
KLK13 kallikrein-related peptidase 13
KREMEN2 kringle containing transmembrane protein 2
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIN28A lin-28 homolog A (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MST1L macrophage stimulating 1-like
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NF1 neurofibromin 1
NME5 NME/NM23 family member 5
NTF3 neurotrophin 3
OSGIN2 oxidative stress induced growth inhibitor family member 2
PCNX pecanex homolog (Drosophila)
PCSK7 proprotein convertase subtilisin/kexin type 7
PDGFB platelet-derived growth factor beta polypeptide
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
POU4F1 POU class 4 homeobox 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKCI protein kinase C, iota
PSAT1 phosphoserine aminotransferase 1
PTCRA pre T-cell antigen receptor alpha
RAD52 RAD52 homolog (S. cerevisiae)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RIMS2 regulating synaptic membrane exocytosis 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPGRIP1L RPGRIP1-like
RPS3A ribosomal protein S3A
S100A1 S100 calcium binding protein A1
S100A13 S100 calcium binding protein A13
SBNO2 strawberry notch homolog 2 (Drosophila)
SIGLEC7 sialic acid binding Ig-like lectin 7
SIRT5 sirtuin 5
SMAD1 SMAD family member 1
SNX1 sorting nexin 1
SOAT2 sterol O-acyltransferase 2
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPEG SPEG complex locus
SYK spleen tyrosine kinase
TBL1Y transducin (beta)-like 1, Y-linked
TCHH trichohyalin
TECPR2 tectonin beta-propeller repeat containing 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TREM1 triggering receptor expressed on myeloid cells 1
VIPR1 vasoactive intestinal peptide receptor 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
WSCD1 WSC domain containing 1
ZC3H7B zinc finger CCCH-type containing 7B
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADGRG2 adhesion G protein-coupled receptor G2
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BMP10 bone morphogenetic protein 10
BTBD7 BTB (POZ) domain containing 7
C11ORF80 chromosome 11 open reading frame 80
C2ORF68 chromosome 2 open reading frame 68
C3 complement component 3
C7ORF43 chromosome 7 open reading frame 43
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALCOCO1 calcium binding and coiled-coil domain 1
CAMTA2 calmodulin binding transcription activator 2
CCDC132 coiled-coil domain containing 132
CCDC186 coiled-coil domain containing 186
CENPC centromere protein C
CNGB3 cyclic nucleotide gated channel beta 3
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRABP1 cellular retinoic acid binding protein 1
CRELD1 cysteine-rich with EGF-like domains 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DNAL4 dynein, axonemal, light chain 4
DNM1 dynamin 1
DOK2 docking protein 2, 56kDa
F3 coagulation factor III (thromboplastin, tissue factor)
FAM169A family with sequence similarity 169, member A
FILIP1L filamin A interacting protein 1-like
FKBP5 FK506 binding protein 5
FRK fyn-related Src family tyrosine kinase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIST1H2BJ histone cluster 1, H2bj
HYI hydroxypyruvate isomerase (putative)
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KEL Kell blood group, metallo-endopeptidase
KIAA0125 KIAA0125
KIAA1107 KIAA1107
KIF13A kinesin family member 13A
LHX1 LIM homeobox 1
MAGEB2 melanoma antigen family B2
MAGEF1 melanoma antigen family F1
MAL mal, T-cell differentiation protein
MAPKBP1 mitogen-activated protein kinase binding protein 1
MEFV Mediterranean fever
MMP2 matrix metallopeptidase 2
MOCS1 molybdenum cofactor synthesis 1
MON1B MON1 secretory trafficking family member B
MYO1F myosin IF
NCALD neurocalcin delta
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NLRX1 NLR family member X1
NXPH4 neurexophilin 4
NYNRIN NYN domain and retroviral integrase containing
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
ORAI3 ORAI calcium release-activated calcium modulator 3
PACS1 phosphofurin acidic cluster sorting protein 1
PDZD8 PDZ domain containing 8
POLL polymerase (DNA directed), lambda
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPRU protein tyrosine phosphatase, receptor type, U
RAB3D RAB3D, member RAS oncogene family
RNF39 ring finger protein 39
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPL23AP32 ribosomal protein L23a pseudogene 32
SAYSD1 SAYSVFN motif domain containing 1
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLMO1 slowmo homolog 1 (Drosophila)
STX1A syntaxin 1A (brain)
SYNC syncoilin, intermediate filament protein
TBKBP1 TBK1 binding protein 1
TLR2 toll-like receptor 2
TMUB2 transmembrane and ubiquitin-like domain containing 2
TOM1 target of myb1 (chicken)
TRIM21 tripartite motif containing 21
TRIM5 tripartite motif containing 5
TTBK2 tau tubulin kinase 2
TTC30A tetratricopeptide repeat domain 30A
TTLL1 tubulin tyrosine ligase-like family member 1
USP20 ubiquitin specific peptidase 20
USP36 ubiquitin specific peptidase 36
VPS9D1 VPS9 domain containing 1
WDR91 WD repeat domain 91
XK X-linked Kx blood group
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC24 zinc finger, DHHC-type containing 24
ZFHX2 zinc finger homeobox 2
ZNF324 zinc finger protein 324
ZNF350 zinc finger protein 350
ZNF446 zinc finger protein 446
ZNF665 zinc finger protein 665