necroptotic process Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. (Gene Ontology, GO_0070266)
External Link
Similar Terms
Downloads & Tools


13 genes participating in the necroptotic process biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
CYLD cylindromatosis (turban tumor syndrome)
DNM1L dynamin 1-like
FASLG Fas ligand (TNF superfamily, member 6)
MLKL mixed lineage kinase domain-like
PGAM5 phosphoglycerate mutase family member 5
PPIF peptidylprolyl isomerase F
PYGL phosphorylase, glycogen, liver
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
TP53 tumor protein p53
TRPM7 transient receptor potential cation channel, subfamily M, member 7