myofibril Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. (Gene Ontology, GO_0030016)
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347 proteins co-occuring with the myofibril cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TTN titin 3.42795
TNNT2 troponin T type 2 (cardiac) 3.24389
TNNI3 troponin I type 3 (cardiac) 2.91235
TPM1 tropomyosin 1 (alpha) 2.62253
NEB nebulin 2.41084
MYBPC3 myosin binding protein C, cardiac 2.17345
MYOM2 myomesin 2 2.0503
MYOT myotilin 1.78123
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.77405
DNAH8 dynein, axonemal, heavy chain 8 1.71621
MB myoglobin 1.70383
MYBPC2 myosin binding protein C, fast type 1.70383
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 1.69891
LDB3 LIM domain binding 3 1.6106
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.6106
FLNC filamin C, gamma 1.59488
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 1.58334
DMD dystrophin 1.54517
VCL vinculin 1.53726
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.52033
CAPN3 calpain 3, (p94) 1.45251
MYOZ1 myozenin 1 1.3363
CRYAB crystallin, alpha B 1.31519
CAST calpastatin 1.30228
MYPN myopalladin 1.29639
NEBL nebulette 1.29264
ACTN2 actinin, alpha 2 1.28196
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 1.28036
MYOZ2 myozenin 2 1.27027
TCAP titin-cap 1.25075
TNNI1 troponin I type 1 (skeletal, slow) 1.24288
MYOM1 myomesin 1 1.21894
FABP3 fatty acid binding protein 3, muscle and heart 1.19931
CKM creatine kinase, muscle 1.18235
TPM2 tropomyosin 2 (beta) 1.15928
NPPB natriuretic peptide B 1.14904
NPPA natriuretic peptide A 1.12858
CAPN2 calpain 2, (m/II) large subunit 1.12296
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 1.11378
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 1.11378
SYNM synemin, intermediate filament protein 1.08882
TPM3 tropomyosin 3 1.08171
PDLIM3 PDZ and LIM domain 3 1.07359
PYGB phosphorylase, glycogen; brain 1.07359
PYGL phosphorylase, glycogen, liver 1.07308
MYBPC1 myosin binding protein C, slow type 1.07258
PYGM phosphorylase, glycogen, muscle 1.07055
ACTC1 actin, alpha, cardiac muscle 1 1.05236
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 1.05236
BAG3 BCL2-associated athanogene 3 1.04381
CASQ2 calsequestrin 2 (cardiac muscle) 1.04281
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.03779
PLN phospholamban 1.03679
MGAM maltase-glucoamylase 1.00596
MYOD1 myogenic differentiation 1 1.00547
GATA4 GATA binding protein 4 0.994162
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.991225
HSPB2 heat shock 27kDa protein 2 0.990736
UNC45B unc-45 homolog B (C. elegans) 0.987317
DES desmin 0.965512
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.95831
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.95305
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.952573
GSN gelsolin 0.946382
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.94211
MYOG myogenin (myogenic factor 4) 0.927013
MYLK myosin light chain kinase 0.921854
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.915309
CMYA5 cardiomyopathy associated 5 0.90832
FBXO32 F-box protein 32 0.906926
FHL2 four and a half LIM domains 2 0.90321
RYR1 ryanodine receptor 1 (skeletal) 0.901353
FN1 fibronectin 1 0.885166
NRAP nebulin-related anchoring protein 0.880555
DYSF dysferlin 0.868126
CTNS cystinosin, lysosomal cystine transporter 0.864447
ANK1 ankyrin 1, erythrocytic 0.852961
PFKM phosphofructokinase, muscle 0.846532
TMOD1 tropomodulin 1 0.839646
TNNT3 troponin T type 3 (skeletal, fast) 0.83781
GJA1 gap junction protein, alpha 1, 43kDa 0.835974
PKLR pyruvate kinase, liver and RBC 0.808441
TMOD4 tropomodulin 4 (muscle) 0.802938
TRIM32 tripartite motif containing 32 0.802479
MSTN myostatin 0.789649
CAV3 caveolin 3 0.784614
CRP C-reactive protein, pentraxin-related 0.768171
PKM pyruvate kinase, muscle 0.766349
CFL2 cofilin 2 (muscle) 0.757253
ACTA1 actin, alpha 1, skeletal muscle 0.751357
SMYD1 SET and MYND domain containing 1 0.748189
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.745929
TNNI2 troponin I type 2 (skeletal, fast) 0.740965
PNMA2 paraneoplastic Ma antigen 2 0.734217
MEF2C myocyte enhancer factor 2C 0.722134
TRIM55 tripartite motif containing 55 0.721242
PVALB parvalbumin 0.714126
ACTG1 actin gamma 1 0.711908
DNM2 dynamin 2 0.707924
PALLD palladin, cytoskeletal associated protein 0.685517
GFAP glial fibrillary acidic protein 0.684644
CTSS cathepsin S 0.680284
TBX5 T-box 5 0.679849
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 0.665096
TLN2 talin 2 0.66164
CKB creatine kinase, brain 0.646574
MYL1 myosin, light chain 1, alkali; skeletal, fast 0.643144
C16ORF82 chromosome 16 open reading frame 82 0.63544
FHL1 four and a half LIM domains 1 0.632878
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.632451
MYBPH myosin binding protein H 0.631171
S100A1 S100 calcium binding protein A1 0.629039
FKTN fukutin 0.627335
OBSL1 obscurin-like 1 0.623079
CSN1S1 casein alpha s1 0.621804
CS citrate synthase 0.617557
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.612471
MYOZ3 myozenin 3 0.611201
ALB albumin 0.609509
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 0.609086
ENO3 enolase 3 (beta, muscle) 0.599802
RBM20 RNA binding motif protein 20 0.599381
TNNT1 troponin T type 1 (skeletal, slow) 0.596014
CKMT1B creatine kinase, mitochondrial 1B 0.593912
SEPN1 selenoprotein N, 1 0.591812
RBM24 RNA binding motif protein 24 0.589295
MYOM3 myomesin 3 0.586361
TPM4 tropomyosin 4 0.585942
MEF2A myocyte enhancer factor 2A 0.583012
INS insulin 0.582176
TRIM54 tripartite motif containing 54 0.577164
ACHE acetylcholinesterase (Yt blood group) 0.573411
EDN1 endothelin 1 0.573411
QDPR quinoid dihydropteridine reductase 0.571329
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 0.571329
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.570913
RYR2 ryanodine receptor 2 (cardiac) 0.569664
MURC muscle-related coiled-coil protein 0.557214
CAPZB capping protein (actin filament) muscle Z-line, beta 0.552664
SPTB spectrin, beta, erythrocytic 0.551838
TRDN triadin 0.546472
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.544823
DMPK dystrophia myotonica-protein kinase 0.543176
CKMT1A creatine kinase, mitochondrial 1A 0.541117
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 0.532078
ALPK3 alpha-kinase 3 0.525931
PDE5A phosphodiesterase 5A, cGMP-specific 0.521023
IGF1 insulin-like growth factor 1 (somatomedin C) 0.520615
FHOD3 formin homology 2 domain containing 3 0.520615
SYNPO2 synaptopodin 2 0.518165
FKRP fukutin related protein 0.505537
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.505537
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.502288
PGAM2 phosphoglycerate mutase 2 (muscle) 0.499853
XIRP1 xin actin binding repeat containing 1 0.490944
PARVB parvin, beta 0.483676
LCN2 lipocalin 2 0.483676
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.48005
LIMS2 LIM and senescent cell antigen-like domains 2 0.478038
ANKRD23 ankyrin repeat domain 23 0.477233
CALD1 caldesmon 1 0.476831
MYF6 myogenic factor 6 (herculin) 0.476429
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.472011
ACE angiotensin I converting enzyme 0.471609
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.471609
LIMS3 LIM and senescent cell antigen-like domains 3 0.469203
NCKIPSD NCK interacting protein with SH3 domain 0.466799
JPH2 junctophilin 2 0.465998
BPGM 2,3-bisphosphoglycerate mutase 0.464798
SOD2 superoxide dismutase 2, mitochondrial 0.463997
PGAM1 phosphoglycerate mutase 1 (brain) 0.462798
CAPZA3 capping protein (actin filament) muscle Z-line, alpha 3 0.460001
YIPF1 Yip1 domain family, member 1 0.458404
STAC3 SH3 and cysteine rich domain 3 0.448054
PXN paxillin 0.441312
C15ORF52 chromosome 15 open reading frame 52 0.439333
TCEA3 transcription elongation factor A (SII), 3 0.439333
SIMC1 SUMO-interacting motifs containing 1 0.439333
BAG1 BCL2-associated athanogene 0.438937
MYOCD myocardin 0.438146
MIR22 microRNA 22 0.43696
XIRP2 xin actin binding repeat containing 2 0.435775
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.43538
MYEF2 myelin expression factor 2 0.433012
MMP10 matrix metallopeptidase 10 0.432618
NEXN nexilin (F actin binding protein) 0.431041
CTAG2 cancer/testis antigen 2 0.428284
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.428284
AK1 adenylate kinase 1 0.421212
MEF2D myocyte enhancer factor 2D 0.420428
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.415337
ILK integrin-linked kinase 0.414946
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.410649
HSPB3 heat shock 27kDa protein 3 0.409869
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.409479
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 0.408309
GDF15 growth differentiation factor 15 0.40675
FBXL22 F-box and leucine-rich repeat protein 22 0.405971
HAND2 heart and neural crest derivatives expressed 2 0.405582
LMNA lamin A/C 0.400527
LRTM1 leucine-rich repeats and transmembrane domains 1 0.399363
ANK2 ankyrin 2, neuronal 0.390455
SMYD5 SMYD family member 5 0.387751
CALR3 calreticulin 3 0.386979
BAG2 BCL2-associated athanogene 2 0.386593
SMYD4 SET and MYND domain containing 4 0.381969
TLN1 talin 1 0.381969
ATP11A ATPase, class VI, type 11A 0.380429
CA3 carbonic anhydrase III 0.37966
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 0.378507
PDLIM5 PDZ and LIM domain 5 0.372366
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.371982
MYL5 myosin, light chain 5, regulatory 0.370833
CAT catalase 0.370833
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 0.368919
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.367006
MYF5 myogenic factor 5 0.365477
LRRC39 leucine rich repeat containing 39 0.356705
SRI sorcin 0.355944
TCF15 transcription factor 15 (basic helix-loop-helix) 0.355563
TAZ tafazzin 0.354422
BCHE butyrylcholinesterase 0.350243
SMYD2 SET and MYND domain containing 2 0.349863
FTL ferritin, light polypeptide 0.349863
ZYX zyxin 0.348346
MTM1 myotubularin 1 0.347967
FTH1 ferritin, heavy polypeptide 1 0.347967
FEN1 flap structure-specific endonuclease 1 0.347587
BIN1 bridging integrator 1 0.346071
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.341151
RIPK4 receptor-interacting serine-threonine kinase 4 0.339639
GPX5 glutathione peroxidase 5 0.338884
RCAN1 regulator of calcineurin 1 0.337751
NBR1 neighbor of BRCA1 gene 1 0.336619
DCTN4 dynactin 4 (p62) 0.336619
GPX4 glutathione peroxidase 4 0.333225
DUSP27 dual specificity phosphatase 27 (putative) 0.331342
ACPP acid phosphatase, prostate 0.328708
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.328332
CTSB cathepsin B 0.323825
CST3 cystatin C 0.32345
GPX1 glutathione peroxidase 1 0.3227
MMP2 matrix metallopeptidase 2 0.322325
KCTD6 potassium channel tetramerization domain containing 6 0.320077
GPBP1 GC-rich promoter binding protein 1 0.319328
LMOD3 leiomodin 3 (fetal) 0.317082
LGALS3 lectin, galactoside-binding, soluble, 3 0.307377
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1 0.30626
ACTB actin, beta 0.304399
AMPD1 adenosine monophosphate deaminase 1 0.30254
APOLD1 apolipoprotein L domain containing 1 0.301054
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.298826
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.296972
ADM adrenomedullin 0.29623
NOS1 nitric oxide synthase 1 (neuronal) 0.295489
POMK protein-O-mannose kinase 0.295489
ATE1 arginyltransferase 1 0.289569
PAX7 paired box 7 0.289569
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.289199
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.281821
HK1 hexokinase 1 0.281821
LRRC10 leucine rich repeat containing 10 0.27998
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.277406
SORBS1 sorbin and SH3 domain containing 1 0.275936
TNNC1 troponin C type 1 (slow) 0.275202
FMN1 formin 1 0.273734
RAVER1 ribonucleoprotein, PTB-binding 1 0.271533
BMP10 bone morphogenetic protein 10 0.271167
FRG1 FSHD region gene 1 0.269701
FLNA filamin A, alpha 0.261296
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.261296
LAMP2 lysosomal-associated membrane protein 2 0.260566
PRKD1 protein kinase D1 0.260202
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.259473
PFDN4 prefoldin subunit 4 0.258745
SORBS2 sorbin and SH3 domain containing 2 0.257289
REN renin 0.256925
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.25438
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.252564
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.249664
INMT indolethylamine N-methyltransferase 0.249664
TYRO3 TYRO3 protein tyrosine kinase 0.247854
UTRN utrophin 0.244962
FBP1 fructose-1,6-bisphosphatase 1 0.244962
ZFPM1 zinc finger protein, FOG family member 1 0.242437
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.234891
AHNAK2 AHNAK nucleoprotein 2 0.234891
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.234174
CTSD cathepsin D 0.233101
TUBE1 tubulin, epsilon 1 0.232029
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.231315
FERMT2 fermitin family member 2 0.228464
DST dystonin 0.226686
ROCK1P1 Rho-associated, coiled-coil containing protein kinase 1 pseudogene 1 0.224913
NEURL1 neuralized E3 ubiquitin protein ligase 1 0.22385
TXLNB taxilin beta 0.221378
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.220321
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.219265
FILIP1L filamin A interacting protein 1-like 0.218914
HAND1 heart and neural crest derivatives expressed 1 0.21681
CTSL cathepsin L 0.215063
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.209169
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.208137
GATA6 GATA binding protein 6 0.207451
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.206423
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.206082
PARVA parvin, alpha 0.205059
DSP desmoplakin 0.203699
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 0.203361
C1QTNF3 C1q and tumor necrosis factor related protein 3 0.203361
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.199993
CAPNS1 calpain, small subunit 1 0.196339
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.194371
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.19307
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.191777
BCO2 beta-carotene oxygenase 2 0.190814
LAMA2 laminin, alpha 2 0.190814
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.189857
EMD emerin 0.188905
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 0.18859
ALPP alkaline phosphatase, placental 0.186708
ALDOC aldolase C, fructose-bisphosphate 0.186397
ALPPL2 alkaline phosphatase, placental-like 2 0.186397
RCAN3 RCAN family member 3 0.186087
AHNAK AHNAK nucleoprotein 0.185777
ALPL alkaline phosphatase, liver/bone/kidney 0.185777
AKAP1 A kinase (PRKA) anchor protein 1 0.185777
NEURL2 neuralized E3 ubiquitin protein ligase 2 0.184547
NOS3 nitric oxide synthase 3 (endothelial cell) 0.183935
HES3 hes family bHLH transcription factor 3 0.183328
LMCD1 LIM and cysteine-rich domains 1 0.182122
FOXO3 forkhead box O3 0.180634
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 0.176305
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.175466
GLB1 galactosidase, beta 1 0.172201
CAPN1 calpain 1, (mu/I) large subunit 0.171149
NES nestin 0.170629
PTK2 protein tyrosine kinase 2 0.170114
GMEB1 glucocorticoid modulatory element binding protein 1 0.169604
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.167125
ENHO energy homeostasis associated 0.166167
CD40LG CD40 ligand 0.1632
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.1632
GAA glucosidase, alpha; acid 0.16233
VPREB1 pre-B lymphocyte 1 0.160254
YIPF2 Yip1 domain family, member 2 0.15776
CRIP3 cysteine-rich protein 3 0.157218