muscle fiber splitting Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description Fiber splitting or branching is a common finding in human and rat skeletal muscle pathology. Fiber splitting refers to longitudinal halving of the complete fiber, while branching originates from a regenerating end of a necrotic fiber as invaginations of the sarcolemma. In fiber branching, one end of the fiber remains intact as a single entity, while the other end has several branches. (Human Phenotype Ontology, HP_0003555)
External Link http://compbio.charite.de/hpoweb/showterm?id=HP:0003555
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Genes

8 genes associated with the muscle fiber splitting phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
CRYAB crystallin, alpha B
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DYSF dysferlin
FLNC filamin C, gamma
LDB3 LIM domain binding 3
MYOT myotilin
TNXB tenascin XB
TRPV4 transient receptor potential cation channel, subfamily V, member 4