monobenzone-5312 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the monobenzone-5312 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ABHD2 abhydrolase domain containing 2
ABHD6 abhydrolase domain containing 6
APOC1 apolipoprotein C-I
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARTN artemin
ASPH aspartate beta-hydroxylase
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BMP4 bone morphogenetic protein 4
C10ORF95 chromosome 10 open reading frame 95
C5AR2 complement component 5a receptor 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD82 CD82 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CISH cytokine inducible SH2-containing protein
CYLD cylindromatosis (turban tumor syndrome)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DEAF1 DEAF1 transcription factor
DMC1 DNA meiotic recombinase 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EML3 echinoderm microtubule associated protein like 3
FADS3 fatty acid desaturase 3
FAS Fas cell surface death receptor
FGD1 FYVE, RhoGEF and PH domain containing 1
FGFR4 fibroblast growth factor receptor 4
FLCN folliculin
FOXN3 forkhead box N3
GREB1 growth regulation by estrogen in breast cancer 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMOX1 heme oxygenase 1
IFIH1 interferon induced with helicase C domain 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL4R interleukin 4 receptor
IL6R interleukin 6 receptor
INO80D INO80 complex subunit D
IRF6 interferon regulatory factor 6
JAG1 jagged 1
JRK Jrk homolog (mouse)
KAT6B K(lysine) acetyltransferase 6B
KIF1A kinesin family member 1A
LMF2 lipase maturation factor 2
LMNA lamin A/C
LRP5L low density lipoprotein receptor-related protein 5-like
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP1S microtubule-associated protein 1S
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAPT microtubule-associated protein tau
MVD mevalonate (diphospho) decarboxylase
MYL10 myosin, light chain 10, regulatory
NADK NAD kinase
NAV2 neuron navigator 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OSBPL2 oxysterol binding protein-like 2
PAX5 paired box 5
PGBD5 piggyBac transposable element derived 5
PKD1 polycystic kidney disease 1 (autosomal dominant)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLL polymerase (DNA directed), lambda
RAB3A RAB3A, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RASAL1 RAS protein activator like 1 (GAP1 like)
RBPMS RNA binding protein with multiple splicing
RHBDD3 rhomboid domain containing 3
S100A4 S100 calcium binding protein A4
SEC24D SEC24 family member D
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SFXN3 sideroflexin 3
SGSH N-sulfoglucosamine sulfohydrolase
SIX2 SIX homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SREBF2 sterol regulatory element binding transcription factor 2
SRRM2 serine/arginine repetitive matrix 2
TADA2A transcriptional adaptor 2A
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBL1Y transducin (beta)-like 1, Y-linked
TBX10 T-box 10
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCP11L1 t-complex 11, testis-specific-like 1
TMEM63A transmembrane protein 63A
TMPRSS3 transmembrane protease, serine 3
TPST2 tyrosylprotein sulfotransferase 2
TRIM2 tripartite motif containing 2
TTC38 tetratricopeptide repeat domain 38
TTLL3 tubulin tyrosine ligase-like family member 3
VAX2 ventral anterior homeobox 2
VIPR2 vasoactive intestinal peptide receptor 2
ZNF318 zinc finger protein 318
ZNF510 zinc finger protein 510

decreased expression

Symbol Name
ACVR2A activin A receptor, type IIA
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
AP1AR adaptor-related protein complex 1 associated regulatory protein
ARHGAP11A Rho GTPase activating protein 11A
ARHGAP12 Rho GTPase activating protein 12
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
C11ORF71 chromosome 11 open reading frame 71
C9ORF40 chromosome 9 open reading frame 40
CCDC92 coiled-coil domain containing 92
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC73 cell division cycle 73
CDCA3 cell division cycle associated 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
CTSC cathepsin C
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEPDC1 DEP domain containing 1
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
ECT2 epithelial cell transforming 2
EHD3 EH-domain containing 3
EPHA4 EPH receptor A4
FAM64A family with sequence similarity 64, member A
GAR1 GAR1 ribonucleoprotein
GHR growth hormone receptor
GLTSCR1 glioma tumor suppressor candidate region gene 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
H1F0 H1 histone family, member 0
HIST1H1D histone cluster 1, H1d
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BI histone cluster 1, H2bi
HIST1H3G histone cluster 1, H3g
HIST1H4C histone cluster 1, H4c
HIST3H2A histone cluster 3, H2a
HMGB3 high mobility group box 3
HMGB3P1 high mobility group box 3 pseudogene 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
ICK intestinal cell (MAK-like) kinase
JRKL JRK-like
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF20B kinesin family member 20B
KIF23 kinesin family member 23
LINC00115 long intergenic non-protein coding RNA 115
LMCD1 LIM and cysteine-rich domains 1
LMNB1 lamin B1
MAP9 microtubule-associated protein 9
METTL2B methyltransferase like 2B
METTL4 methyltransferase like 4
NDC80 NDC80 kinetochore complex component
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUSAP1 nucleolar and spindle associated protein 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
SH3GL1 SH3-domain GRB2-like 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMYD3 SET and MYND domain containing 3
SNORA21 small nucleolar RNA, H/ACA box 21
SPDL1 spindle apparatus coiled-coil protein 1
STIL SCL/TAL1 interrupting locus
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUN2 Sad1 and UNC84 domain containing 2
TACC3 transforming, acidic coiled-coil containing protein 3
TESK2 testis-specific kinase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM230 transmembrane protein 230
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TROAP trophinin associated protein
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBQLN4 ubiquilin 4
WDR46 WD repeat domain 46
WWC2 WW and C2 domain containing 2
ZNF273 zinc finger protein 273