monastrol-596 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the monastrol-596 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGGF1 angiogenic factor with G patch and FHA domains 1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
AQP3 aquaporin 3 (Gill blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASCC1 activating signal cointegrator 1 complex subunit 1
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATRX alpha thalassemia/mental retardation syndrome X-linked
B3GAT3 beta-1,3-glucuronyltransferase 3
BCL2L1 BCL2-like 1
C1ORF115 chromosome 1 open reading frame 115
C20ORF27 chromosome 20 open reading frame 27
C2ORF44 chromosome 2 open reading frame 44
C3ORF52 chromosome 3 open reading frame 52
CA7 carbonic anhydrase VII
CCHCR1 coiled-coil alpha-helical rod protein 1
CCSER2 coiled-coil serine-rich protein 2
CD44 CD44 molecule (Indian blood group)
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHERP calcium homeostasis endoplasmic reticulum protein
COG5 component of oligomeric golgi complex 5
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRTC1 CREB regulated transcription coactivator 1
DMWD dystrophia myotonica, WD repeat containing
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
ELMO2 engulfment and cell motility 2
EPN3 epsin 3
ERF Ets2 repressor factor
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR4 fibroblast growth factor receptor 4
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLRX glutaredoxin (thioltransferase)
HPX hemopexin
HUS1 HUS1 checkpoint homolog (S. pombe)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KIAA0141 KIAA0141
LIG3 ligase III, DNA, ATP-dependent
LIM2 lens intrinsic membrane protein 2, 19kDa
LPAR1 lysophosphatidic acid receptor 1
LRRC1 leucine rich repeat containing 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP3L microfibrillar-associated protein 3-like
MRPL44 mitochondrial ribosomal protein L44
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NADK NAD kinase
NCKAP1 NCK-associated protein 1
NDN necdin, melanoma antigen (MAGE) family member
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPY neuropeptide Y
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PCGF1 polycomb group ring finger 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PDGFB platelet-derived growth factor beta polypeptide
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLCG1 phospholipase C, gamma 1
POMT2 protein-O-mannosyltransferase 2
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRB1 proline-rich protein BstNI subfamily 1
PROL1 proline rich, lacrimal 1
PTRF polymerase I and transcript release factor
RNF141 ring finger protein 141
RNF24 ring finger protein 24
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRAS related RAS viral (r-ras) oncogene homolog
SCAMP1 secretory carrier membrane protein 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SEC24D SEC24 family member D
SERBP1 SERPINE1 mRNA binding protein 1
SERINC3 serine incorporator 3
SGMS1 sphingomyelin synthase 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORT1 sortilin 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
SRP72 signal recognition particle 72kDa
SRSF8 serine/arginine-rich splicing factor 8
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCEA2 transcription elongation factor A (SII), 2
TK2 thymidine kinase 2, mitochondrial
TMEM161A transmembrane protein 161A
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNS2 tensin 2
TPST2 tyrosylprotein sulfotransferase 2
TSPAN32 tetraspanin 32
URM1 ubiquitin related modifier 1
VASP vasodilator-stimulated phosphoprotein
VAV2 vav 2 guanine nucleotide exchange factor
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WSCD1 WSC domain containing 1
ZFP36 ZFP36 ring finger protein
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
C1ORF159 chromosome 1 open reading frame 159
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CFAP70 cilia and flagella associated protein 70
CHKB choline kinase beta
COPZ2 coatomer protein complex, subunit zeta 2
COX17 COX17 cytochrome c oxidase copper chaperone
CTSD cathepsin D
DAGLA diacylglycerol lipase, alpha
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCP1A decapping mRNA 1A
DIXDC1 DIX domain containing 1
DLK2 delta-like 2 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DRP2 dystrophin related protein 2
DUSP8 dual specificity phosphatase 8
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ECE2 endothelin converting enzyme 2
EFNA3 ephrin-A3
EIF5A2 eukaryotic translation initiation factor 5A2
ENO3 enolase 3 (beta, muscle)
EPHA4 EPH receptor A4
EPX eosinophil peroxidase
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM114A2 family with sequence similarity 114, member A2
FZD2 frizzled class receptor 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GJD2 gap junction protein, delta 2, 36kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GMIP GEM interacting protein
H2AFJ H2A histone family, member J
HABP2 hyaluronan binding protein 2
HCG4B HLA complex group 4B (non-protein coding)
HEATR3 HEAT repeat containing 3
HIST1H1C histone cluster 1, H1c
HIST1H2AM histone cluster 1, H2am
HIST1H4J histone cluster 1, H4j
HOXC4 homeobox C4
IGFBP6 insulin-like growth factor binding protein 6
IL19 interleukin 19
INSIG2 insulin induced gene 2
IRAK4 interleukin-1 receptor-associated kinase 4
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIF5A kinesin family member 5A
KLHL26 kelch-like family member 26
KPTN kaptin (actin binding protein)
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LMNB2 lamin B2
LOC145678 uncharacterized LOC145678
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAPK3 mitogen-activated protein kinase 3
MGP matrix Gla protein
MOSPD3 motile sperm domain containing 3
MYL5 myosin, light chain 5, regulatory
MYOZ3 myozenin 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
OMG oligodendrocyte myelin glycoprotein
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PELP1 proline, glutamate and leucine rich protein 1
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PQLC3 PQ loop repeat containing 3
PRKCE protein kinase C, epsilon
PRSS2 protease, serine, 2 (trypsin 2)
PTGES2 prostaglandin E synthase 2
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RNF43 ring finger protein 43
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SDC3 syndecan 3
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNHG20 small nucleolar RNA host gene 20
SPINK4 serine peptidase inhibitor, Kazal type 4
STAB2 stabilin 2
STX1A syntaxin 1A (brain)
TCP10 t-complex 10
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMEM121 transmembrane protein 121
TMEM246 transmembrane protein 246
TOE1 target of EGR1, member 1 (nuclear)
TRIM25 tripartite motif containing 25
TUBA4B tubulin, alpha 4b
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBQLN4 ubiquilin 4
ZFHX4 zinc finger homeobox 4
ZNF134 zinc finger protein 134
ZNF250 zinc finger protein 250
ZNF408 zinc finger protein 408
ZNF74 zinc finger protein 74
ZNF768 zinc finger protein 768