moderate Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

383 genes co-occuring with the biological term moderate in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACE angiotensin I converting enzyme
ACTA1 actin, alpha 1, skeletal muscle
ADA adenosine deaminase
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA2A adenosine A2a receptor
ADRB2 adrenoceptor beta 2, surface
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAS2 5'-aminolevulinate synthase 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
AMACR alpha-methylacyl-CoA racemase
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATM ATM serine/threonine kinase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATXN7L3 ataxin 7-like 3
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
BAD BCL2-associated agonist of cell death
BBC3 BCL2 binding component 3
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDNF brain-derived neurotrophic factor
BLK BLK proto-oncogene, Src family tyrosine kinase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRAP BRCA1 associated protein
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
C5AR2 complement component 5a receptor 2
CALCA calcitonin-related polypeptide alpha
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC38 coiled-coil domain containing 38
CCL21 chemokine (C-C motif) ligand 21
CCND1 cyclin D1
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD151 CD151 molecule (Raph blood group)
CD1A CD1a molecule
CD28 CD28 molecule
CD34 CD34 molecule
CD4 CD4 molecule
CD83 CD83 molecule
CD86 CD86 molecule
CDC25B cell division cycle 25B
CDH13 cadherin 13
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDX2 caudal type homeobox 2
CETP cholesteryl ester transfer protein, plasma
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHEK2 checkpoint kinase 2
CHGA chromogranin A
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLDN19 claudin 19
CLEC12A C-type lectin domain family 12, member A
CLEC4M C-type lectin domain family 4, member M
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COL11A2 collagen, type XI, alpha 2
COL1A1 collagen, type I, alpha 1
COL9A3 collagen, type IX, alpha 3
COMT catechol-O-methyltransferase
COX1
CPNE3 copine III
CREB1 cAMP responsive element binding protein 1
CREM cAMP responsive element modulator
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CSF3 colony stimulating factor 3 (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSD cathepsin D
CTSK cathepsin K
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCK deoxycytidine kinase
DEFB1 defensin, beta 1
DLG3 discs, large homolog 3 (Drosophila)
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
EGFR epidermal growth factor receptor
EGR2 early growth response 2
EPHB2 EPH receptor B2
EPO erythropoietin
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FABP4 fatty acid binding protein 4, adipocyte
FAM175A family with sequence similarity 175, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
FLG filaggrin
FLT1 fms-related tyrosine kinase 1
FOXP1 forkhead box P1
FPR1 formyl peptide receptor 1
FTL ferritin, light polypeptide
FTO fat mass and obesity associated
FTSJ1 FtsJ RNA methyltransferase homolog 1 (E. coli)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GAB1 GRB2-associated binding protein 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GATA3 GATA binding protein 3
GC group-specific component (vitamin D binding protein)
GH1 growth hormone 1
GHRL ghrelin/obestatin prepropeptide
GJA4 gap junction protein, alpha 4, 37kDa
GJB1 gap junction protein, beta 1, 32kDa
GJB2 gap junction protein, beta 2, 26kDa
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPBAR1 G protein-coupled bile acid receptor 1
GPC3 glypican 3
GPER1 G protein-coupled estrogen receptor 1
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GPX2 glutathione peroxidase 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GTPBP3 GTP binding protein 3 (mitochondrial)
HBA2 hemoglobin, alpha 2
HBB hemoglobin, beta
HCRT hypocretin (orexin) neuropeptide precursor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HNF4A hepatocyte nuclear factor 4, alpha
HOXB13 homeobox B13
HRH3 histamine receptor H3
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IER3IP1 immediate early response 3 interacting protein 1
IFN1@ interferon, type 1, cluster
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGHA1 immunoglobulin heavy constant alpha 1
IL10 interleukin 10
IL16 interleukin 16
IL17A interleukin 17A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RL1 interleukin 1 receptor-like 1
IL2RA interleukin 2 receptor, alpha
IL33 interleukin 33
IL3RA interleukin 3 receptor, alpha (low affinity)
IL5 interleukin 5
IL6 interleukin 6
IL7 interleukin 7
IRGM immunity-related GTPase family, M
IRS1 insulin receptor substrate 1
ITGA1 integrin, alpha 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDR kinase insert domain receptor
KLK3 kallikrein-related peptidase 3
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT8 keratin 8, type II
LAMB3 laminin, beta 3
LATS1 large tumor suppressor kinase 1
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LEP leptin
LEPQTL1 Leptin, serum levels of
LIF leukemia inhibitory factor
LPL lipoprotein lipase
LTC4S leukotriene C4 synthase
MAOA monoamine oxidase A
MAPK1 mitogen-activated protein kinase 1
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC4R melanocortin 4 receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MGMT O-6-methylguanine-DNA methyltransferase
MIR21 microRNA 21
MIR34C microRNA 34c
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSL1 male-specific lethal 1 homolog (Drosophila)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYBPC1 myosin binding protein C, slow type
MYO6 myosin VI
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NES nestin
NKX2-1 NK2 homeobox 1
NLRP3 NLR family, pyrin domain containing 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOXA1 NADPH oxidase activator 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPPB natriuretic peptide B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
OPA1 optic atrophy 1 (autosomal dominant)
OPRM1 opioid receptor, mu 1
OTOG otogelin
OTOGL otogelin-like
OTSC2 otosclerosis 2
OTSC5 otosclerosis 5
PALB2 partner and localizer of BRCA2
PARK7 parkinson protein 7
PCA3 prostate cancer associated 3 (non-protein coding)
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE5A phosphodiesterase 5A, cGMP-specific
PDLIM1 PDZ and LIM domain 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PF4V1 platelet factor 4 variant 1
PIGR polymeric immunoglobulin receptor
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKD2L1 polycystic kidney disease 2-like 1
PLCE1 phospholipase C, epsilon 1
PLN phospholamban
POLI polymerase (DNA directed) iota
PON1 paraoxonase 1
PON3 paraoxonase 3
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCDBP protein kinase C, delta binding protein
PRKCZ protein kinase C, zeta
PRL prolactin
PROCR protein C receptor, endothelial
PSEN2 presenilin 2
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTH parathyroid hormone
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTX3 pentraxin 3, long
RAB11A RAB11A, member RAS oncogene family
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBP4 retinol binding protein 4, plasma
RCOR3 REST corepressor 3
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RELN reelin
REN renin
RUNX1 runt-related transcription factor 1
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SETX senataxin
SHBG sex hormone-binding globulin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A17 solute carrier family 22, member 17
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC38A5 solute carrier family 38, member 5
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD4 SMAD family member 4
SNAP25 synaptosomal-associated protein, 25kDa
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SREBF1 sterol regulatory element binding transcription factor 1
SSTR1 somatostatin receptor 1
SSTR3 somatostatin receptor 3
SSTR5 somatostatin receptor 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STRC stereocilin
SZT2 seizure threshold 2 homolog (mouse)
TAC3 tachykinin 3
TACR1 tachykinin receptor 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TFAM transcription factor A, mitochondrial
TFCP2 transcription factor CP2
TFRC transferrin receptor
TG thyroglobulin
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TH tyrosine hydroxylase
THEM4 thioesterase superfamily member 4
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TP53 tumor protein p53
TP63 tumor protein p63
TPO thyroid peroxidase
TRIM5 tripartite motif containing 5
TUBB3 tubulin, beta 3 class III
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UGT1A UDP glucuronosyltransferase 1 family, polypeptide A complex locus
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UIMC1 ubiquitin interaction motif containing 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WDR36 WD repeat domain 36
WFS1 Wolfram syndrome 1 (wolframin)
WISP1 WNT1 inducible signaling pathway protein 1
WISP2 WNT1 inducible signaling pathway protein 2
XPA xeroderma pigmentosum, complementation group A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNF492 zinc finger protein 492