mitral valve insufficiency Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

161 genes co-occuring with the disease mitral valve insufficiency in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
OPN3 opsin 3 2.16184
EFS embryonal Fyn-associated substrate 1.58136
ACE angiotensin I converting enzyme 1.52732
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 1.47682
NPPA natriuretic peptide A 1.37774
WDR20 WD repeat domain 20 1.36161
NPPB natriuretic peptide B 1.28785
PDZK1IP1 PDZK1 interacting protein 1 1.24211
TNMD tenomodulin 1.23473
WRNIP1 Werner helicase interacting protein 1 1.11856
CMA1 chymase 1, mast cell 1.03072
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 1.02692
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 0.994439
MYRF myelin regulatory factor 0.930828
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.911845
C7ORF49 chromosome 7 open reading frame 49 0.903621
LAX1 lymphocyte transmembrane adaptor 1 0.879833
GIN1 gypsy retrotransposon integrase 1 0.877376
MVD mevalonate (diphospho) decarboxylase 0.851583
DUOXA1 dual oxidase maturation factor 1 0.844211
FBN1 fibrillin 1 0.827819
CRP C-reactive protein, pentraxin-related 0.826589
PDLIM1 PDZ and LIM domain 1 0.819206
EXTL3 exostosin-like glycosyltransferase 3 0.805667
CS citrate synthase 0.761454
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.758601
DYNLRB1 dynein, light chain, roadblock-type 1 0.721673
DNAH8 dynein, axonemal, heavy chain 8 0.721673
MSTO1 misato 1, mitochondrial distribution and morphology regulator 0.72127
PEX12 peroxisomal biogenesis factor 12 0.695504
TNNT2 troponin T type 2 (cardiac) 0.684292
IGLV1-47 immunoglobulin lambda variable 1-47 0.679898
MYSM1 Myb-like, SWIRM and MPN domains 1 0.671925
MON1A MON1 secretory trafficking family member A 0.67113
PLG plasminogen 0.667152
HP haptoglobin 0.664372
HPR haptoglobin-related protein 0.658026
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.656046
EVC Ellis van Creveld protein 0.648533
TNNI3 troponin I type 3 (cardiac) 0.639857
RPS2 ribosomal protein S2 0.634742
FAT3 FAT atypical cadherin 3 0.631991
HLA-DOB major histocompatibility complex, class II, DO beta 0.60342
OR3A1 olfactory receptor, family 3, subfamily A, member 1 0.595233
DHDH dihydrodiol dehydrogenase (dimeric) 0.592116
ETV3 ets variant 3 0.592116
SLN sarcolipin 0.579661
ADRB1 adrenoceptor beta 1 0.557509
CA5B carbonic anhydrase VB, mitochondrial 0.540442
COX5A cytochrome c oxidase subunit Va 0.528835
CT45A1 cancer/testis antigen family 45, member A1 0.52343
PLN phospholamban 0.521888
SRR serine racemase 0.515725
ADM adrenomedullin 0.50459
CKB creatine kinase, brain 0.498085
GPR182 G protein-coupled receptor 182 0.497321
PRAC1 prostate cancer susceptibility candidate 1 0.495793
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 0.491215
GALNS galactosamine (N-acetyl)-6-sulfatase 0.489691
LECT1 leukocyte cell derived chemotaxin 1 0.475634
NOTO notochord homeobox 0.472604
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.471468
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 0.470711
PFKM phosphofructokinase, muscle 0.468819
CPB1 carboxypeptidase B1 (tissue) 0.466172
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.465794
SRI sorcin 0.448064
GLG1 golgi glycoprotein 1 0.443171
IGLV9-49 immunoglobulin lambda variable 9-49 0.442418
TTC34 tetratricopeptide repeat domain 34 0.442042
BIN2 bridging integrator 2 0.44129
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.438658
DCN decorin 0.434899
TUBGCP4 tubulin, gamma complex associated protein 4 0.431144
CKM creatine kinase, muscle 0.429266
SPATA5 spermatogenesis associated 5 0.426265
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.426265
FOXO4 forkhead box O4 0.424389
GUSB glucuronidase, beta 0.410161
UTS2 urotensin 2 0.40904
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.404931
AURKAIP1 aurora kinase A interacting protein 1 0.404557
KRT84 keratin 84, type II 0.395235
CA2 carbonic anhydrase II 0.387051
ESPN espin 0.384822
IL17C interleukin 17C 0.383708
MMP1 matrix metallopeptidase 1 0.383337
PF4 platelet factor 4 0.379626
EDN1 endothelin 1 0.371107
POLB polymerase (DNA directed), beta 0.369258
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.368888
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 0.368518
BBS2 Bardet-Biedl syndrome 2 0.367779
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.365193
VWF von Willebrand factor 0.360764
NAAA N-acylethanolamine acid amidase 0.360026
ZFYVE9 zinc finger, FYVE domain containing 9 0.35892
IDS iduronate 2-sulfatase 0.35892
FUT2 fucosyltransferase 2 (secretor status included) 0.355972
ALB albumin 0.350084
MAPT microtubule-associated protein tau 0.346777
DCT dopachrome tautomerase 0.346042
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.342739
PRRC2A proline-rich coiled-coil 2A 0.340539
TRIM25 tripartite motif containing 25 0.339806
NOTCH1 notch 1 0.318635
REN renin 0.318272
IGLV3-10 immunoglobulin lambda variable 3-10 0.313189
IL1RL1 interleukin 1 receptor-like 1 0.30848
FBL fibrillarin 0.30631
RSPO1 R-spondin 1 0.291539
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.285802
GJA5 gap junction protein, alpha 5, 40kDa 0.283655
FBLN1 fibulin 1 0.282225
IGLL5 immunoglobulin lambda-like polypeptide 5 0.275445
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.273664
RING1 ring finger protein 1 0.273308
COL2A1 collagen, type II, alpha 1 0.271886
ATF2 activating transcription factor 2 0.266203
EFNA5 ephrin-A5 0.260891
FGB fibrinogen beta chain 0.260184
POMT2 protein-O-mannosyltransferase 2 0.25877
PPT1 palmitoyl-protein thioesterase 1 0.258064
TNF tumor necrosis factor 0.254536
RCAN1 regulator of calcineurin 1 0.253831
FBLL1 fibrillarin-like 1 0.253831
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.253479
SCG5 secretogranin V 0.252774
TOB1 transducer of ERBB2, 1 0.252422
FAT1 FAT atypical cadherin 1 0.250663
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 0.245396
CTF1 cardiotrophin 1 0.241546
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.240148
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.23945
PLAT plasminogen activator, tissue 0.235616
MAP9 microtubule-associated protein 9 0.23353
EVL Enah/Vasp-like 0.230755
NANP N-acetylneuraminic acid phosphatase 0.227642
FXYD1 FXYD domain containing ion transport regulator 1 0.220766
PHB2 prohibitin 2 0.215653
TBK1 TANK-binding kinase 1 0.20658
CLEC3B C-type lectin domain family 3, member B 0.203604
DSE dermatan sulfate epimerase 0.201635
RAB27A RAB27A, member RAS oncogene family 0.19742
MMP2 matrix metallopeptidase 2 0.19582
KIAA0101 KIAA0101 0.192657
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.188022
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.187719
POMT1 protein-O-mannosyltransferase 1 0.183835
DAND5 DAN domain family member 5, BMP antagonist 0.180937
PHGDH phosphoglycerate dehydrogenase 0.178682
FLNA filamin A, alpha 0.175146
LATS2 large tumor suppressor kinase 2 0.175146
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 0.171535
CD59 CD59 molecule, complement regulatory protein 0.166319
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.164359
WEE1 WEE1 G2 checkpoint kinase 0.163111
PTGDR prostaglandin D2 receptor (DP) 0.162505
TIMP4 TIMP metallopeptidase inhibitor 4 0.162109
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.158266
SIRPA signal-regulatory protein alpha 0.158097