mitochondrial pyruvate dehydrogenase complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. (Gene Ontology, GO_0005967)
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Genes

20 proteins co-occuring with the mitochondrial pyruvate dehydrogenase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
DLD dihydrolipoamide dehydrogenase 1.24288
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 1.15262
PDHX pyruvate dehydrogenase complex, component X 1.06954
PDC phosducin 0.66726
CYR61 cysteine-rich, angiogenic inducer, 61 0.618406
RIPK4 receptor-interacting serine-threonine kinase 4 0.586361
GADD45A growth arrest and DNA-damage-inducible, alpha 0.524294
CD1D CD1d molecule 0.477233
CD99 CD99 molecule 0.458404
NBL1 neuroblastoma 1, DAN family BMP antagonist 0.434196
SIRT3 sirtuin 3 0.424353
TYRO3 TYRO3 protein tyrosine kinase 0.41182
VCP valosin containing protein 0.390841
SP100 SP100 nuclear antigen 0.389296
MGAM maltase-glucoamylase 0.264581
P4HB prolyl 4-hydroxylase, beta polypeptide 0.256197
IRS1 insulin receptor substrate 1 0.221025
STAT1 signal transducer and activator of transcription 1, 91kDa 0.166643
INS insulin 0.159462
CALR calreticulin 0.157943