mitochondrial permeability transition pore complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D). (Gene Ontology, GO_0005757)
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Genes

127 proteins co-occuring with the mitochondrial permeability transition pore complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PPIF peptidylprolyl isomerase F 2.83774
BAX BCL2-associated X protein 1.71435
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.54065
GSK3B glycogen synthase kinase 3 beta 1.36857
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.22205
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.19828
HK2 hexokinase 2 1.17414
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.1685
VDAC1 voltage-dependent anion channel 1 1.09289
BCL2L1 BCL2-like 1 1.07461
TSPO translocator protein (18kDa) 0.988294
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.980501
FCF1 FCF1 rRNA-processing protein 0.928892
SOD2 superoxide dismutase 2, mitochondrial 0.850665
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 0.769083
COL6A1 collagen, type VI, alpha 1 0.765893
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.748641
BCL2 B-cell CLL/lymphoma 2 0.720797
CAT catalase 0.689888
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.689451
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.669425
TUSC2 tumor suppressor candidate 2 0.659913
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.656895
PARP1 poly (ADP-ribose) polymerase 1 0.64958
TP53 tumor protein p53 0.64915
RBM41 RNA binding motif protein 41 0.641001
MFN2 mitofusin 2 0.634586
NOS3 nitric oxide synthase 3 (endothelial cell) 0.611201
DIABLO diablo, IAP-binding mitochondrial protein 0.596014
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.580504
FKBP9 FK506 binding protein 9, 63 kDa 0.574244
FKBP6 FK506 binding protein 6, 36kDa 0.560528
FKBP7 FK506 binding protein 7 0.558042
FKBP3 FK506 binding protein 3, 25kDa 0.557629
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.554732
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.545236
ANXA5 annexin A5 0.540706
HK1 hexokinase 1 0.538238
ENDOG endonuclease G 0.523476
DNTT DNA nucleotidylexotransferase 0.505131
CABIN1 calcineurin binding protein 1 0.501476
KNG1 kininogen 1 0.494585
DNM1L dynamin 1-like 0.492966
FKBP10 FK506 binding protein 10, 65 kDa 0.484079
SIRT3 sirtuin 3 0.469604
ACO2 aconitase 2, mitochondrial 0.462398
RCAN1 regulator of calcineurin 1 0.449643
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.429072
MFN1 mitofusin 1 0.427891
FKBP5 FK506 binding protein 5 0.414946
FKBP2 FK506 binding protein 2, 13kDa 0.413773
JUN jun proto-oncogene 0.411039
CSNK1A1 casein kinase 1, alpha 1 0.409089
RHOD ras homolog family member D 0.40675
ASPG asparaginase 0.405582
MAPK3 mitogen-activated protein kinase 3 0.401693
HINT2 histidine triad nucleotide binding protein 2 0.385436
TYRL tyrosinase-like (pseudogene) 0.380045
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.370067
ELK1 ELK1, member of ETS oncogene family 0.367388
SPATA21 spermatogenesis associated 21 0.365859
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.362804
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.352522
MTNR1A melatonin receptor 1A 0.348346
MX2 MX dynamin-like GTPase 2 0.339639
ADORA1 adenosine A1 receptor 0.339639
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.339261
COL15A1 collagen, type XV, alpha 1 0.336996
COL6A3 collagen, type VI, alpha 3 0.334356
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.330966
MAP2K1 mitogen-activated protein kinase kinase 1 0.325702
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.324951
DNAH8 dynein, axonemal, heavy chain 8 0.320826
CERS6 ceramide synthase 6 0.320826
COL18A1 collagen, type XVIII, alpha 1 0.320826
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.319328
IK IK cytokine, down-regulator of HLA II 0.312597
VDAC3 voltage-dependent anion channel 3 0.309613
PTEN phosphatase and tensin homolog 0.305888
CS citrate synthase 0.303655
APAF1 apoptotic peptidase activating factor 1 0.299197
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.298084
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.296972
MAPK8 mitogen-activated protein kinase 8 0.290308
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.287352
COQ4 coenzyme Q4 0.284769
PTS 6-pyruvoyltetrahydropterin synthase 0.279612
PAOX polyamine oxidase (exo-N4-amino) 0.271167
PINK1 PTEN induced putative kinase 1 0.269335
FKBP4 FK506 binding protein 4, 59kDa 0.268237
CERS5 ceramide synthase 5 0.267139
COQ6 coenzyme Q6 monooxygenase 0.260202
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.256925
OPA1 optic atrophy 1 (autosomal dominant) 0.250751
PLA2G1B phospholipase A2, group IB (pancreas) 0.244962
TNF tumor necrosis factor 0.24424
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.238837
RPS6 ribosomal protein S6 0.234891
CERS1 ceramide synthase 1 0.230245
MRPL49 mitochondrial ribosomal protein L49 0.229888
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.229532
MGAM maltase-glucoamylase 0.227041
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 0.225267
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.21646
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.215412
ANO6 anoctamin 6 0.211933
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.210549
INS insulin 0.208137
VDAC2 voltage-dependent anion channel 2 0.205399
GPX1 glutathione peroxidase 1 0.197662
SIRT4 sirtuin 4 0.195681
HMOX1 heme oxygenase 1 0.195353
GSTM2 glutathione S-transferase mu 2 (muscle) 0.195025
IGLV2-8 immunoglobulin lambda variable 2-8 0.18859
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.180634
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.179752
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.178877
NAV1 neuron navigator 1 0.176305
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.175466
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 0.168847
DDIT3 DNA-damage-inducible transcript 3 0.16342
PTK2B protein tyrosine kinase 2 beta 0.162117
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.160456
MAOB monoamine oxidase B 0.160456
NAMPT nicotinamide phosphoribosyltransferase 0.159074
MICU1 mitochondrial calcium uptake 1 0.158692
GPX5 glutathione peroxidase 5 0.156863