mitochondrial matrix Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. (Gene Ontology, GO_0005759)
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Genes

677 proteins co-occuring with the mitochondrial matrix cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TFAM transcription factor A, mitochondrial 2.73873
POLG polymerase (DNA directed), gamma 2.55303
MT-ATP8 ATP synthase F0 subunit 8 2.25893
C10ORF2 chromosome 10 open reading frame 2 2.05904
HVCN1 hydrogen voltage gated channel 1 1.99333
CS citrate synthase 1.88348
NPTX2 neuronal pentraxin II 1.78649
UCN urocortin 1.75531
NDC1 NDC1 transmembrane nucleoporin 1.71621
GJB2 gap junction protein, beta 2, 26kDa 1.71249
DGUOK deoxyguanosine kinase 1.70445
COX6CP4 cytochrome c oxidase subunit VIc pseudogene 4 1.58391
TYMP thymidine phosphorylase 1.57245
SOD2 superoxide dismutase 2, mitochondrial 1.56389
OGG1 8-oxoguanine DNA glycosylase 1.55934
COX4I1 cytochrome c oxidase subunit IV isoform 1 1.48588
NRF1 nuclear respiratory factor 1 1.48023
OTC ornithine carbamoyltransferase 1.45251
TFB2M transcription factor B2, mitochondrial 1.44968
MTERF1 mitochondrial transcription termination factor 1 1.43839
SLC26A4 solute carrier family 26 (anion exchanger), member 4 1.39239
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 1.39016
POLRMT polymerase (RNA) mitochondrial (DNA directed) 1.38073
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 1.36802
MPV17 MpV17 mitochondrial inner membrane protein 1.36472
SSBP1 single-stranded DNA binding protein 1, mitochondrial 1.36417
FXN frataxin 1.34065
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 1.30873
BCKDK branched chain ketoacid dehydrogenase kinase 1.2921
RAG1 recombination activating gene 1 1.28943
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.27611
MFN2 mitofusin 2 1.27186
TFB1M transcription factor B1, mitochondrial 1.26815
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.2314
INS insulin 1.22984
PPARG peroxisome proliferator-activated receptor gamma 1.21946
ACO2 aconitase 2, mitochondrial 1.2055
FAM20C family with sequence similarity 20, member C 1.19057
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 1.18697
TK2 thymidine kinase 2, mitochondrial 1.17363
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 1.16286
DNAH8 dynein, axonemal, heavy chain 8 1.13676
SURF1 surfeit 1 1.1148
MDH1 malate dehydrogenase 1, NAD (soluble) 1.10613
SUCLG1 succinate-CoA ligase, alpha subunit 1.10256
ARHGAP21 Rho GTPase activating protein 21 1.10002
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.09798
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 1.08781
MFN1 mitofusin 1 1.08222
RPS3 ribosomal protein S3 1.04984
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 1.04381
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.0423
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 1.02281
CAT catalase 1.01635
SIRT1 sirtuin 1 1.01585
SIRT3 sirtuin 3 1.00843
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 1.003
OPA1 optic atrophy 1 (autosomal dominant) 0.995632
GJB3 gap junction protein, beta 3, 31kDa 0.995142
MUTYH mutY homolog 0.98927
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.98488
SCAI suppressor of cancer cell invasion 0.984393
HSPA4 heat shock 70kDa protein 4 0.984393
OAT ornithine aminotransferase 0.981959
SCO2 SCO2 cytochrome c oxidase assembly protein 0.976619
TP53 tumor protein p53 0.976135
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 0.966474
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.964069
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.963107
EDNRB endothelin receptor type B 0.955439
DLD dihydrolipoamide dehydrogenase 0.940215
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 0.936432
GPX1 glutathione peroxidase 1 0.932187
WFS1 Wolfram syndrome 1 (wolframin) 0.932187
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 0.919514
PPIF peptidylprolyl isomerase F 0.912045
TOP1MT topoisomerase (DNA) I, mitochondrial 0.909716
LONP1 lon peptidase 1, mitochondrial 0.901818
MRPS7 mitochondrial ribosomal protein S7 0.89672
LIG3 ligase III, DNA, ATP-dependent 0.894868
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.891169
STAB2 stabilin 2 0.888397
MRPL12 mitochondrial ribosomal protein L12 0.885166
UNG uracil-DNA glycosylase 0.873647
DAP3 death associated protein 3 0.866746
GPX4 glutathione peroxidase 4 0.865367
BAX BCL2-associated X protein 0.864907
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.86123
DMGDH dimethylglycine dehydrogenase 0.849287
GPX5 glutathione peroxidase 5 0.846073
SRY sex determining region Y 0.840564
GABPB1 GA binding protein transcription factor, beta subunit 1 0.839646
C21ORF2 chromosome 21 open reading frame 2 0.835056
LRPPRC leucine-rich pentatricopeptide repeat containing 0.832761
DCK deoxycytidine kinase 0.831384
AMELY amelogenin, Y-linked 0.82037
MRPS12 mitochondrial ribosomal protein S12 0.819911
GJB6 gap junction protein, beta 6, 30kDa 0.818993
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.805689
DHFR dihydrofolate reductase 0.796062
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.791022
TMEM70 transmembrane protein 70 0.790106
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.790106
MTIF3 mitochondrial translational initiation factor 3 0.781869
AMELX amelogenin, X-linked 0.78004
TK1 thymidine kinase 1, soluble 0.762707
IMMT inner membrane protein, mitochondrial 0.757707
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.752263
DNM1L dynamin 1-like 0.749094
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.747285
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.746833
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.744574
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.737813
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.733768
ETFDH electron-transferring-flavoprotein dehydrogenase 0.732422
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.731524
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 0.731076
SCO1 SCO1 cytochrome c oxidase assembly protein 0.726599
MTRF1L mitochondrial translational release factor 1-like 0.726599
TCEA1 transcription elongation factor A (SII), 1 0.71946
MRPL11 mitochondrial ribosomal protein L11 0.717236
MSH2 mutS homolog 2 0.716791
HSPE1 heat shock 10kDa protein 1 0.715458
ANOS1 anosmin 1 0.715458
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.708366
COX5B cytochrome c oxidase subunit Vb 0.703507
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 0.702185
SYPL1 synaptophysin-like 1 0.691202
GFM1 G elongation factor, mitochondrial 1 0.689451
MRPS36 mitochondrial ribosomal protein S36 0.681591
ZFY zinc finger protein, Y-linked 0.681155
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.675934
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.672894
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 0.671159
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.670725
PIF1 PIF1 5'-to-3' DNA helicase 0.668992
EEF1A1P6 eukaryotic translation elongation factor 1 alpha 1 pseudogene 6 0.665529
PTCD3 pentatricopeptide repeat domain 3 0.662935
SARDH sarcosine dehydrogenase 0.662503
HADH hydroxyacyl-CoA dehydrogenase 0.659913
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.655172
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.652159
MTIF2 mitochondrial translational initiation factor 2 0.651299
PUS1 pseudouridylate synthase 1 0.646145
TOP1 topoisomerase (DNA) I 0.638005
PC pyruvate carboxylase 0.63544
EXOG endo/exonuclease (5'-3'), endonuclease G-like 0.635013
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.633305
DBT dihydrolipoamide branched chain transacylase E2 0.630318
C1QBP complement component 1, q subcomponent binding protein 0.629892
RPS14 ribosomal protein S14 0.62393
MTPAP mitochondrial poly(A) polymerase 0.621804
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 0.620954
COX5A cytochrome c oxidase subunit Va 0.620529
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 0.61968
PTCD1 pentatricopeptide repeat domain 1 0.614165
GLRX5 glutaredoxin 5 0.610355
GCK glucokinase (hexokinase 4) 0.609509
ENDOG endonuclease G 0.609086
ETHE1 ethylmalonic encephalopathy 1 0.605284
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 0.602331
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.602331
DHODH dihydroorotate dehydrogenase (quinone) 0.600223
ACAA1 acetyl-CoA acyltransferase 1 0.600223
APOE apolipoprotein E 0.594332
AK3 adenylate kinase 3 0.591392
ACTG1 actin gamma 1 0.590973
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) 0.588456
TST thiosulfate sulfurtransferase (rhodanese) 0.585105
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.582594
CRYZ crystallin, zeta (quinone reductase) 0.582594
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) 0.580504
MGAM maltase-glucoamylase 0.580504
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.580086
MTRF1 mitochondrial translational release factor 1 0.579251
ALAS1 5'-aminolevulinate synthase 1 0.577164
DUS3L dihydrouridine synthase 3-like (S. cerevisiae) 0.576747
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.572994
ACTB actin, beta 0.572578
INSC inscuteable homolog (Drosophila) 0.572162
SIRT5 sirtuin 5 0.567169
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.565508
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 0.565508
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 0.565092
MGME1 mitochondrial genome maintenance exonuclease 1 0.563432
MALSU1 mitochondrial assembly of ribosomal large subunit 1 0.562602
RNMTL1 RNA methyltransferase like 1 0.558457
HRSP12 heat-responsive protein 12 0.554318
COX11 COX11 cytochrome c oxidase copper chaperone 0.554318
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 0.552664
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli) 0.551838
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.551425
NDUFA4 NDUFA4, mitochondrial complex associated 0.548947
ELAC2 elaC ribonuclease Z 2 0.548122
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.537827
PHB prohibitin 0.537416
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 0.537005
KLHL17 kelch-like family member 17 0.53413
RAG2 recombination activating gene 2 0.533309
GSTTP1 glutathione S-transferase theta pseudogene 1 0.530847
FH fumarate hydratase 0.530438
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.528798
NNT nicotinamide nucleotide transhydrogenase 0.527569
GSTT1 glutathione S-transferase theta 1 0.527569
MIPEP mitochondrial intermediate peptidase 0.52675
ECI2 enoyl-CoA delta isomerase 2 0.523476
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 0.521432
GCG glucagon 0.521432
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.520615
RPS12 ribosomal protein S12 0.516124
TNF tumor necrosis factor 0.515716
SCCPDH saccharopine dehydrogenase (putative) 0.510011
GLRX2 glutaredoxin 2 0.509604
OTOF otoferlin 0.509604
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.508383
HK2 hexokinase 2 0.508383
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.506757
ZFX zinc finger protein, X-linked 0.505131
AFG3L2 AFG3-like AAA ATPase 2 0.505131
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.504318
RPS11 ribosomal protein S11 0.502693
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.500664
ESRRA estrogen-related receptor alpha 0.497826
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.49661
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 0.49499
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.492561
GSR glutathione reductase 0.488923
CD4 CD4 molecule 0.488519
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.485289
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 0.485289
TDP1 tyrosyl-DNA phosphodiesterase 1 0.484483
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 0.483273
AVPR2 arginine vasopressin receptor 2 0.482467
NFS1 NFS1 cysteine desulfurase 0.482467
COX15 cytochrome c oxidase assembly homolog 15 (yeast) 0.479647
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.479647
GSTM1 glutathione S-transferase mu 1 0.479245
RNASEH1 ribonuclease H1 0.478843
COX18 COX18 cytochrome c oxidase assembly factor 0.47844
C1D C1D nuclear receptor corepressor 0.476831
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.476429
NTHL1 nth endonuclease III-like 1 (E. coli) 0.475223
RPS13 ribosomal protein S13 0.474018
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.473215
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 0.473215
MTO1 mitochondrial tRNA translation optimization 1 0.472412
GPI glucose-6-phosphate isomerase 0.472412
SIRT4 sirtuin 4 0.470807
BCL2L1 BCL2-like 1 0.470807
MRPS33 mitochondrial ribosomal protein S33 0.468001
PPARA peroxisome proliferator-activated receptor alpha 0.466799
MRPS22 mitochondrial ribosomal protein S22 0.464397
BPGM 2,3-bisphosphoglycerate mutase 0.462798
SERAC1 serine active site containing 1 0.462798
MRPL37 mitochondrial ribosomal protein L37 0.458803
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.458404
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.452825
PRDX3 peroxiredoxin 3 0.452029
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.450836
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.450438
LARS leucyl-tRNA synthetase 0.446862
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 0.444085
ALAS2 5'-aminolevulinate synthase 2 0.443689
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 0.442896
NME3 NME/NM23 nucleoside diphosphate kinase 3 0.441708
MYH14 myosin, heavy chain 14, non-muscle 0.44052
MPI mannose phosphate isomerase 0.44052
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.439728
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.438146
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.438146
PARK7 parkinson protein 7 0.436565
HMOX1 heme oxygenase 1 0.43538
NOS3 nitric oxide synthase 3 (endothelial cell) 0.434591
JAG2 jagged 2 0.434196
CBS cystathionine-beta-synthase 0.433012
MRPS27 mitochondrial ribosomal protein S27 0.431829
PTCD2 pentatricopeptide repeat domain 2 0.429465
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.429072
NME4 NME/NM23 nucleoside diphosphate kinase 4 0.427497
PRRC2A proline-rich coiled-coil 2A 0.421997
LIG4 ligase IV, DNA, ATP-dependent 0.41886
CRAT carnitine O-acetyltransferase 0.418077
LIG1 ligase I, DNA, ATP-dependent 0.413382
RECQL4 RecQ protein-like 4 0.412601
HK1 hexokinase 1 0.411039
TLR9 toll-like receptor 9 0.410259
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.409869
MRPL43 mitochondrial ribosomal protein L43 0.409869
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) 0.40714
AARS alanyl-tRNA synthetase 0.40675
PINK1 PTEN induced putative kinase 1 0.405971
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.405971
PARP1 poly (ADP-ribose) polymerase 1 0.398587
ACADVL acyl-CoA dehydrogenase, very long chain 0.393936
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 0.389682
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 0.388523
DNTT DNA nucleotidylexotransferase 0.388137
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.387751
HNF1A HNF1 homeobox A 0.386979
APOLD1 apolipoprotein L domain containing 1 0.386979
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 0.385051
TXN thioredoxin 0.384665
RNASEH2A ribonuclease H2, subunit A 0.382739
LCLAT1 lysocardiolipin acyltransferase 1 0.382739
FABP3 fatty acid binding protein 3, muscle and heart 0.380429
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.37966
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 0.379276
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 0.378507
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.377354
SLIRP SRA stem-loop interacting RNA binding protein 0.37697
NSUN4 NOP2/Sun domain family, member 4 0.371982
MTG1 mitochondrial ribosome-associated GTPase 1 0.370067
FEV FEV (ETS oncogene family) 0.368919
FBXL4 F-box and leucine-rich repeat protein 4 0.367771
PID1 phosphotyrosine interaction domain containing 1 0.364713
TERT telomerase reverse transcriptase 0.364713
SIRT7 sirtuin 7 0.360896
UST uronyl-2-sulfotransferase 0.360133
NOTCH3 notch 3 0.359752
GSTK1 glutathione S-transferase kappa 1 0.359371
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 0.35899
ADPRHL2 ADP-ribosylhydrolase like 2 0.357847
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.356705
FGA fibrinogen alpha chain 0.356324
ZNF410 zinc finger protein 410 0.354802
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 0.354422
LDHB lactate dehydrogenase B 0.354042
CCL1 chemokine (C-C motif) ligand 1 0.352142
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.351002
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.349105
PRDX5 peroxiredoxin 5 0.347208
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.346829
FST follistatin 0.346071
RAD52 RAD52 homolog (S. cerevisiae) 0.345692
ALB albumin 0.345692
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.343799
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.341907
F13B coagulation factor XIII, B polypeptide 0.339639
TUFM Tu translation elongation factor, mitochondrial 0.339639
DENR density-regulated protein 0.337751
ACAT1 acetyl-CoA acetyltransferase 1 0.336996
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K 0.336996
ETFB electron-transfer-flavoprotein, beta polypeptide 0.335487
TPI1 triosephosphate isomerase 1 0.335487
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.33511
COG8 component of oligomeric golgi complex 8 0.333602
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 0.333602
RPS5 ribosomal protein S5 0.332095
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.332095
ISCU iron-sulfur cluster assembly enzyme 0.330966
SLC25A38 solute carrier family 25, member 38 0.330589
FDX1 ferredoxin 1 0.328332
SLC25A27 solute carrier family 25, member 27 0.326829
CREB1 cAMP responsive element binding protein 1 0.326829
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.326453
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 0.325327
ECI1 enoyl-CoA delta isomerase 1 0.324951
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.323075
HLA-C major histocompatibility complex, class I, C 0.3227
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 0.322325
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 0.321575
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.320451
PITRM1 pitrilysin metallopeptidase 1 0.318579
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.318205
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 0.314465
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 0.313344
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.313344
HES2 hes family bHLH transcription factor 2 0.310358
RPS2 ribosomal protein S2 0.310358
IRS1 insulin receptor substrate 1 0.30924
AGK acylglycerol kinase 0.30924
ATM ATM serine/threonine kinase 0.308867
CPT1A carnitine palmitoyltransferase 1A (liver) 0.308494
RPS19 ribosomal protein S19 0.308122
MRPL41 mitochondrial ribosomal protein L41 0.307749
GDAP1 ganglioside induced differentiation associated protein 1 0.307377
BRCA1 breast cancer 1, early onset 0.306632
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.305515
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.305143
RGMB repulsive guidance molecule family member b 0.304771
CYCS cytochrome c, somatic 0.303655
CTU1 cytosolic thiouridylase subunit 1 0.303283
ATXN3 ataxin 3 0.301797
PTEN phosphatase and tensin homolog 0.301425
PHB2 prohibitin 2 0.301425
NOTCH4 notch 4 0.301054
SREBF1 sterol regulatory element binding transcription factor 1 0.299569
SULT4A1 sulfotransferase family 4A, member 1 0.299569
NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.298826
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 0.298084
MLH1 mutL homolog 1 0.296972
GFER growth factor, augmenter of liver regeneration 0.295489
KIAA0391 KIAA0391 0.292897
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.292897
FCF1 FCF1 rRNA-processing protein 0.292157
MSRA methionine sulfoxide reductase A 0.291787
RPL10 ribosomal protein L10 0.291417
GLS2 glutaminase 2 (liver, mitochondrial) 0.290678
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.290678
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.289199
PARL presenilin associated, rhomboid-like 0.28846
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 0.28846
PPA2 pyrophosphatase (inorganic) 2 0.28846
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 0.288091
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.286245
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.286245
C12ORF65 chromosome 12 open reading frame 65 0.285507
COX17 COX17 cytochrome c oxidase copper chaperone 0.285138
MFF mitochondrial fission factor 0.285138
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.284032
HTT huntingtin 0.283663
GLRX glutaredoxin (thioltransferase) 0.283295
AUH AU RNA binding protein/enoyl-CoA hydratase 0.282926
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 0.282189
POLI polymerase (DNA directed) iota 0.281453
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.281085
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.27998
ICT1 immature colon carcinoma transcript 1 0.279245
RPF2 ribosome production factor 2 homolog (S. cerevisiae) 0.278877
NME6 NME/NM23 nucleoside diphosphate kinase 6 0.278509
ACAA2 acetyl-CoA acyltransferase 2 0.277774
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.277406
YME1L1 YME1-like 1 ATPase 0.275936
MRPS34 mitochondrial ribosomal protein S34 0.275569
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 0.275569
MRPL55 mitochondrial ribosomal protein L55 0.275569
MRPL42 mitochondrial ribosomal protein L42 0.275569
MRPL10 mitochondrial ribosomal protein L10 0.275569
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 0.275202
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.274468
PMPCB peptidase (mitochondrial processing) beta 0.273
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.271167
RYR1 ryanodine receptor 1 (skeletal) 0.269701
TSPO translocator protein (18kDa) 0.269335
IGFL2 IGF-like family member 2 0.269335
PPY2P pancreatic polypeptide 2, pseudogene 0.268969
PABPC5 poly(A) binding protein, cytoplasmic 5 0.268969
ACOT12 acyl-CoA thioesterase 12 0.268237
IARS isoleucyl-tRNA synthetase 0.267139
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 0.266408
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.265677
TXN2 thioredoxin 2 0.265311
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.264581
HCCS holocytochrome c synthase 0.263485
GGN gametogenetin 0.263485
NCR2 natural cytotoxicity triggering receptor 2 0.26312
MTERF3 mitochondrial transcription termination factor 3 0.26312
CDSN corneodesmosin 0.260566
GLS glutaminase 0.260566
RBP3 retinol binding protein 3, interstitial 0.259473
SIRT6 sirtuin 6 0.259109
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.258745
FAM109A family with sequence similarity 109, member A 0.258381
ACSS2 acyl-CoA synthetase short-chain family member 2 0.258016
OXCT1 3-oxoacid CoA transferase 1 0.257289
MRPL34 mitochondrial ribosomal protein L34 0.257289
SOX13 SRY (sex determining region Y)-box 13 0.256925
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.256197
MRPS9 mitochondrial ribosomal protein S9 0.256197
EYA1 EYA transcriptional coactivator and phosphatase 1 0.255834
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.25547
MTFMT mitochondrial methionyl-tRNA formyltransferase 0.25547
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.25438
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 0.253291
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) 0.252927
EXO1 exonuclease 1 0.252927
MRPL38 mitochondrial ribosomal protein L38 0.252927
POU3F4 POU class 3 homeobox 4 0.252564
METAP1D methionyl aminopeptidase type 1D (mitochondrial) 0.251839
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 0.251839
ACSM4 acyl-CoA synthetase medium-chain family member 4 0.251839
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.251476
UBIAD1 UbiA prenyltransferase domain containing 1 0.251114
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.251114
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 0.251114
GSTA4 glutathione S-transferase alpha 4 0.250026
MRPL27 mitochondrial ribosomal protein L27 0.250026
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 0.248578
SIX1 SIX homeobox 1 0.248578
GSTA1 glutathione S-transferase alpha 1 0.247854
MRPS5 mitochondrial ribosomal protein S5 0.246407
HTRA2 HtrA serine peptidase 2 0.245685
RHOD ras homolog family member D 0.244962
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.244601
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 0.243879
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.243158
HAGH hydroxyacylglutathione hydrolase 0.240996
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa 0.240636
LDHA lactate dehydrogenase A 0.240276
LINC00207 long intergenic non-protein coding RNA 207 0.239916
LEP leptin 0.239197
RNF14 ring finger protein 14 0.239197
MICU1 mitochondrial calcium uptake 1 0.23776
PFKM phosphofructokinase, muscle 0.237042
CCL16 chemokine (C-C motif) ligand 16 0.237042
MRPS11 mitochondrial ribosomal protein S11 0.237042
MRPS14 mitochondrial ribosomal protein S14 0.235249
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.235249
POMC proopiomelanocortin 0.234533
RBBP9 retinoblastoma binding protein 9 0.234174
RPS15 ribosomal protein S15 0.233817
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.233817
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.233817
CFH complement factor H 0.232744
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 0.232029
GCDH glutaryl-CoA dehydrogenase 0.230958
DNM1 dynamin 1 0.230245
METTL17 methyltransferase like 17 0.229532
MPV17L2 MPV17 mitochondrial membrane protein-like 2 0.228464
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 0.228108
MLYCD malonyl-CoA decarboxylase 0.227397
GSTA3 glutathione S-transferase alpha 3 0.227397
C1QL3 complement component 1, q subcomponent-like 3 0.226686
GRSF1 G-rich RNA sequence binding factor 1 0.226331
SIRT2 sirtuin 2 0.225976
UPP1 uridine phosphorylase 1 0.225976
SRBD1 S1 RNA binding domain 1 0.225976
GSTA2 glutathione S-transferase alpha 2 0.225622
C6ORF25 chromosome 6 open reading frame 25 0.225267
ACAD9 acyl-CoA dehydrogenase family, member 9 0.225267
IGF1 insulin-like growth factor 1 (somatomedin C) 0.224913
AGA aspartylglucosaminidase 0.22173
INPP1 inositol polyphosphate-1-phosphatase 0.220673
MCTP1 multiple C2 domains, transmembrane 1 0.220321
CCBL1 cysteine conjugate-beta lyase, cytoplasmic 0.219617
WDR36 WD repeat domain 36 0.218914
ACOT2 acyl-CoA thioesterase 2 0.218914
MRPL48 mitochondrial ribosomal protein L48 0.217511
AASS aminoadipate-semialdehyde synthase 0.21681
MRPL18 mitochondrial ribosomal protein L18 0.216111
BCL2 B-cell CLL/lymphoma 2 0.214714
TIMM23B translocase of inner mitochondrial membrane 23 homolog B (yeast) 0.214017
BDH1 3-hydroxybutyrate dehydrogenase, type 1 0.213669
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 0.212974
TEFM transcription elongation factor, mitochondrial 0.212974
MRPL53 mitochondrial ribosomal protein L53 0.211933
TMPRSS13 transmembrane protease, serine 13 0.211587
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.210894
RHO rhodopsin 0.210203
TEAD2 TEA domain family member 2 0.209513
FTO fat mass and obesity associated 0.209169
PKLR pyruvate kinase, liver and RBC 0.208481
MAOA monoamine oxidase A 0.207794
FEN1 flap structure-specific endonuclease 1 0.207108
LETM2 leucine zipper-EF-hand containing transmembrane protein 2 0.207108
DNASE1L1 deoxyribonuclease I-like 1 0.206766
AGXT alanine-glyoxylate aminotransferase 0.206423
VSX2 visual system homeobox 2 0.20574
SACS sacsin molecular chaperone 0.20574
ATAD1 ATPase family, AAA domain containing 1 0.20574
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 0.205059
TMEM14C transmembrane protein 14C 0.204718
ERCC2 excision repair cross-complementation group 2 0.204378
INSR insulin receptor 0.204378
CALCR calcitonin receptor 0.203022
MRPS15 mitochondrial ribosomal protein S15 0.202684
BAHCC1 BAH domain and coiled-coil containing 1 0.202684
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.202684
HSPA14 heat shock 70kDa protein 14 0.202346
MTERF2 mitochondrial transcription termination factor 2 0.201672
KIAA1429 KIAA1429 0.201672
NOA1 nitric oxide associated 1 0.201672
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 0.201335
LATS1 large tumor suppressor kinase 1 0.199993
FPR3 formyl peptide receptor 3 0.199659
NLRP3 NLR family, pyrin domain containing 3 0.199659
PHKA2 phosphorylase kinase, alpha 2 (liver) 0.198991
FBF1 Fas (TNFRSF6) binding factor 1 0.198325
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.198325
MRRF mitochondrial ribosome recycling factor 0.198325
ESR1 estrogen receptor 1 0.197993
POU5F1 POU class 5 homeobox 1 0.197662
IL6 interleukin 6 0.197662
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 0.196999
SAG S-antigen; retina and pineal gland (arrestin) 0.196669
GLB1 galactosidase, beta 1 0.195353
DHFRL1 dihydrofolate reductase-like 1 0.195353
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 0.195025
AMPD1 adenosine monophosphate deaminase 1 0.194698
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.194045
MRPL28 mitochondrial ribosomal protein L28 0.194045
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 0.192423
GSTZ1 glutathione S-transferase zeta 1 0.1921
PNKP polynucleotide kinase 3'-phosphatase 0.1921
DMD dystrophin 0.190814
MB myoglobin 0.190175
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.190175
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 0.189857
MAOB monoamine oxidase B 0.189222
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.188905
DAZ2 deleted in azoospermia 2 0.187646
MRPS30 mitochondrial ribosomal protein S30 0.18702
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 0.18702
RPL5 ribosomal protein L5 0.186708
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.186708
MUT methylmalonyl CoA mutase 0.186397
MRPL47 mitochondrial ribosomal protein L47 0.186087
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 0.185777
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.185777
PAPD7 PAP associated domain containing 7 0.185469
DAZ1 deleted in azoospermia 1 0.185469
PDE2A phosphodiesterase 2A, cGMP-stimulated 0.184853
GLDC glycine dehydrogenase (decarboxylating) 0.184547
PCCB propionyl CoA carboxylase, beta polypeptide 0.184241
MMD monocyte to macrophage differentiation-associated 0.184241
ESR2 estrogen receptor 2 (ER beta) 0.182723
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 0.182422
JUN jun proto-oncogene 0.181524
AK1 adenylate kinase 1 0.18093
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.18093
NANOG Nanog homeobox 0.18093
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.180634
PRIM1 primase, DNA, polypeptide 1 (49kDa) 0.180045
TAZ tafazzin 0.179459
BHMT betaine--homocysteine S-methyltransferase 0.179167
CAPN13 calpain 13 0.178877
APP amyloid beta (A4) precursor protein 0.178877
MSH6 mutS homolog 6 0.178299
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 0.177724
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.177439
CLEC3A C-type lectin domain family 3, member A 0.177154
PKM pyruvate kinase, muscle 0.17687
RPTOR regulatory associated protein of MTOR, complex 1 0.175745
OPTN optineurin 0.175745
ACE angiotensin I converting enzyme 0.175466
CARD17 caspase recruitment domain family, member 17 0.174911
IRF2BP1 interferon regulatory factor 2 binding protein 1 0.174911
ANXA5 annexin A5 0.174635
MRPS10 mitochondrial ribosomal protein S10 0.174635
CHRDL2 chordin-like 2 0.174361
KRTAP1-3 keratin associated protein 1-3 0.174087
RBM23 RNA binding motif protein 23 0.173814
PARK2 parkin RBR E3 ubiquitin protein ligase 0.173814
QARS glutaminyl-tRNA synthetase 0.173273
ATPIF1 ATPase inhibitory factor 1 0.173273
CHML choroideremia-like (Rab escort protein 2) 0.172468
RPF1 ribosome production factor 1 homolog (S. cerevisiae) 0.171673
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.170371
MRPL2 mitochondrial ribosomal protein L2 0.170371
MRPS24 mitochondrial ribosomal protein S24 0.169859
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 0.169859
RARS2 arginyl-tRNA synthetase 2, mitochondrial 0.169604
MRPS16 mitochondrial ribosomal protein S16 0.168847
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.168847
TOP3A topoisomerase (DNA) III alpha 0.168598
NQO1 NAD(P)H dehydrogenase, quinone 1 0.168349
CLEC2B C-type lectin domain family 2, member B 0.167366
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.167125
FGF21 fibroblast growth factor 21 0.166167
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 0.165231
CLEC10A C-type lectin domain family 10, member A 0.164315
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.164089
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.163865
VDAC1 voltage-dependent anion channel 1 0.163641
RPS10 ribosomal protein S10 0.16298
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 0.16233
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.161905
CAPN10 calpain 10 0.161905
PURA purine-rich element binding protein A 0.161905
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 0.161693
GARS glycyl-tRNA synthetase 0.161068
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.160863
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 0.160658
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 0.159462
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 0.159074
FES FES proto-oncogene, tyrosine kinase 0.158882
DNA2 DNA replication helicase/nuclease 2 0.158882
PGK1 phosphoglycerate kinase 1 0.158692
FOXJ3 forkhead box J3 0.158502
HES4 hes family bHLH transcription factor 4 0.158315
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.157943
GZMM granzyme M (lymphocyte met-ase 1) 0.157578
APTX aprataxin 0.157218
DNASE1L2 deoxyribonuclease I-like 2 0.157039
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 0.156513
OAZ3 ornithine decarboxylase antizyme 3 0.156513
NADK NAD kinase 0.156342