minocycline-5077 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the minocycline-5077 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP8L A kinase (PRKA) anchor protein 8-like
AMPD3 adenosine monophosphate deaminase 3
ARHGAP44 Rho GTPase activating protein 44
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATF6B activating transcription factor 6 beta
BMP4 bone morphogenetic protein 4
C1ORF68 chromosome 1 open reading frame 68
C5AR1 complement component 5a receptor 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAPN9 calpain 9
CASP5 caspase 5, apoptosis-related cysteine peptidase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLDN17 claudin 17
CLEC4A C-type lectin domain family 4, member A
CLPS colipase, pancreatic
CNGB3 cyclic nucleotide gated channel beta 3
COL10A1 collagen, type X, alpha 1
CRHR2 corticotropin releasing hormone receptor 2
CSHL1 chorionic somatomammotropin hormone-like 1
CYLD cylindromatosis (turban tumor syndrome)
CYTH3 cytohesin 3
DACH1 dachshund family transcription factor 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DGKA diacylglycerol kinase, alpha 80kDa
DGKQ diacylglycerol kinase, theta 110kDa
DOCK9 dedicator of cytokinesis 9
DRP2 dystrophin related protein 2
EMILIN2 elastin microfibril interfacer 2
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2
GAS7 growth arrest-specific 7
GATA4 GATA binding protein 4
GOLGA8A golgin A8 family, member A
GPER1 G protein-coupled estrogen receptor 1
GRAMD1C GRAM domain containing 1C
HESX1 HESX homeobox 1
HIST1H1D histone cluster 1, H1d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IBSP integrin-binding sialoprotein
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHM immunoglobulin heavy constant mu
IL1RN interleukin 1 receptor antagonist
IL23A interleukin 23, alpha subunit p19
KIF1C kinesin family member 1C
KIF25 kinesin family member 25
KIF25-AS1 KIF25 antisense RNA 1
KRT37 keratin 37, type I
KSR1 kinase suppressor of ras 1
LARP4B La ribonucleoprotein domain family, member 4B
LINC00115 long intergenic non-protein coding RNA 115
LIPE lipase, hormone-sensitive
LPAR4 lysophosphatidic acid receptor 4
MAGEC3 melanoma antigen family C3
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MTAP methylthioadenosine phosphorylase
MTSS1 metastasis suppressor 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC8 mucin 8
N4BP2L1 NEDD4 binding protein 2-like 1
NEUROD1 neuronal differentiation 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PEX5L peroxisomal biogenesis factor 5-like
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRA paired immunoglobin-like type 2 receptor alpha
PLAG1 pleiomorphic adenoma gene 1
PLIN2 perilipin 2
PPARD peroxisome proliferator-activated receptor delta
PRDX2 peroxiredoxin 2
PROX1 prospero homeobox 1
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RNF126P1 ring finger protein 126 pseudogene 1
RPL7 ribosomal protein L7
RTN1 reticulon 1
RUNX1 runt-related transcription factor 1
RYR2 ryanodine receptor 2 (cardiac)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SIRPB1 signal-regulatory protein beta 1
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO1C1 solute carrier organic anion transporter family, member 1C1
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SYCP2 synaptonemal complex protein 2
TBC1D2 TBC1 domain family, member 2
TBC1D22A TBC1 domain family, member 22A
TMEM19 transmembrane protein 19
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
UTS2 urotensin 2
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VEGFB vascular endothelial growth factor B
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WTAP Wilms tumor 1 associated protein
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF219 zinc finger protein 219
ZNF674 zinc finger protein 674
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
AEN apoptosis enhancing nuclease
BAHD1 bromo adjacent homology domain containing 1
C14ORF93 chromosome 14 open reading frame 93
C4ORF29 chromosome 4 open reading frame 29
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDKL3 cyclin-dependent kinase-like 3
CLIP4 CAP-GLY domain containing linker protein family, member 4
CPNE7 copine VII
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTSK cathepsin K
CYBRD1 cytochrome b reductase 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DPF3 D4, zinc and double PHD fingers, family 3
EDIL3 EGF-like repeats and discoidin I-like domains 3
EPHA4 EPH receptor A4
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETNK2 ethanolamine kinase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOSC1 exosome component 1
FAM118A family with sequence similarity 118, member A
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL20RA interleukin 20 receptor, alpha
IL22 interleukin 22
IL4R interleukin 4 receptor
IL7R interleukin 7 receptor
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0556 KIAA0556
KIAA0894 KIAA0894 protein
KLF13 Kruppel-like factor 13
LINC00341 long intergenic non-protein coding RNA 341
LPAR3 lysophosphatidic acid receptor 3
LRRC37A3 leucine rich repeat containing 37, member A3
MANBA mannosidase, beta A, lysosomal
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MXD3 MAX dimerization protein 3
NME5 NME/NM23 family member 5
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDZK1 PDZ domain containing 1
PLCD1 phospholipase C, delta 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLXNB3 plexin B3
POMT2 protein-O-mannosyltransferase 2
PPT2 palmitoyl-protein thioesterase 2
PRR14L proline rich 14-like
PRR16 proline rich 16
PTK6 protein tyrosine kinase 6
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS20 regulator of G-protein signaling 20
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPH3AL rabphilin 3A-like (without C2 domains)
RPL23AP32 ribosomal protein L23a pseudogene 32
SCAI suppressor of cancer cell invasion
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC46A3 solute carrier family 46, member 3
SPTBN2 spectrin, beta, non-erythrocytic 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM104 transmembrane protein 104
TMEM132A transmembrane protein 132A
TMEM8B transmembrane protein 8B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAF2 TNF receptor-associated factor 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TSC22D4 TSC22 domain family, member 4
TUBA3C tubulin, alpha 3c
UBTD1 ubiquitin domain containing 1
VEZT vezatin, adherens junctions transmembrane protein
WDR18 WD repeat domain 18
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZFP30 ZFP30 zinc finger protein
ZFP69B ZFP69 zinc finger protein B
ZNF137P zinc finger protein 137, pseudogene
ZNF141 zinc finger protein 141
ZNF197 zinc finger protein 197
ZNF37BP zinc finger protein 37B, pseudogene
ZNF408 zinc finger protein 408
ZNF41 zinc finger protein 41
ZNF529 zinc finger protein 529
ZNF639 zinc finger protein 639
ZNF668 zinc finger protein 668
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76