migraine Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing. (Human Disease Ontology, DOID_6364)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0002076
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Genes

91 genes associated with the migraine phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
LRP1 low density lipoprotein receptor-related protein 1 1.91562
PRDM16 PR domain containing 16 1.65584
TRPM8 transient receptor potential cation channel, subfamily M, member 8 1.63535
MEF2D myocyte enhancer factor 2D 1.44665
SUGCT succinyl-CoA:glutarate-CoA transferase 1.35521
ASTN2 astrotactin 2 1.35521
PHACTR1 phosphatase and actin regulator 1 1.19958
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 1.15352
FBN2 fibrillin 2 1.15352
HAUS1 HAUS augmin-like complex, subunit 1 1.12851
LEPROTL1 leptin receptor overlapping transcript-like 1 1.12851
MRVI1 murine retrovirus integration site 1 homolog 1.12851
PRKG1 protein kinase, cGMP-dependent, type I 1.11203
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 1.09906
MMP17 matrix metallopeptidase 17 (membrane-inserted) 1.08774
KCNK5 potassium channel, two pore domain subfamily K, member 5 1.08774
TGFB1 transforming growth factor, beta 1 1.05869
MRPL37 mitochondrial ribosomal protein L37 1.05869
WASL Wiskott-Aldrich syndrome-like 1.04365
MARCH4 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase 1.04365
KIAA1456 KIAA1456 1.02289
ADAMTSL1 ADAMTS-like 1 1.00187
ZDHHC6 zinc finger, DHHC-type containing 6 1.00059
ARL15 ADP-ribosylation factor-like 15 1.00059
RSU1 Ras suppressor protein 1 1.00059
KANK1 KN motif and ankyrin repeat domains 1 0.969142
NRP1 neuropilin 1 0.969142
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.969142
HPSE2 heparanase 2 (inactive) 0.942765
SNX24 sorting nexin 24 0.942765
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.942765
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.942765
INSIG2 insulin induced gene 2 0.939636
CDH13 cadherin 13 0.919744
KSR2 kinase suppressor of ras 2 0.919744
SV2C synaptic vesicle glycoprotein 2C 0.899912
PHF20 PHD finger protein 20 0.882984
RABGAP1L RAB GTPase activating protein 1-like 0.882984
ADRA1B adrenoceptor alpha 1B 0.882984
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.882984
SORBS1 sorbin and SH3 domain containing 1 0.882984
PTPRD protein tyrosine phosphatase, receptor type, D 0.868241
IGLL1 immunoglobulin lambda-like polypeptide 1 0.868241
COX7B2 cytochrome c oxidase subunit VIIb2 0.868241
FRMD4A FERM domain containing 4A 0.868241
SMYD3 SET and MYND domain containing 3 0.865569
STK10 serine/threonine kinase 10 0.855449
FOXP1 forkhead box P1 0.855449
CASZ1 castor zinc finger 1 0.855449
ZNF555 zinc finger protein 555 0.848993
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.847125
NF1 neurofibromin 1 0.829801
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.824663
ALK anaplastic lymphoma receptor tyrosine kinase 0.774448
FAM49B family with sequence similarity 49, member B 0.772313
MYLK4 myosin light chain kinase family, member 4 0.771787
ZNF311 zinc finger protein 311 0.763536
NXPH1 neurexophilin 1 0.758788
NAV2 neuron navigator 2 0.758275
COG3 component of oligomeric golgi complex 3 0.738997
GRM7 glutamate receptor, metabotropic 7 0.738997
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.732783
MYO3B myosin IIIB 0.72096
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.689964
ACTN4 actinin, alpha 4 0.684849
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.65699
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.653584
CAMTA1 calmodulin binding transcription activator 1 0.652395
FAM155A family with sequence similarity 155, member A 0.647116
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.634838
STK39 serine threonine kinase 39 0.619932
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.618403
GOLM1 golgi membrane protein 1 0.602436
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 0.594349
IQGAP2 IQ motif containing GTPase activating protein 2 0.592807
ATF7 activating transcription factor 7 0.576549
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.56762
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.501459
CTIF CBP80/20-dependent translation initiation factor 0.455764
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.43117
WAPAL wings apart-like homolog (Drosophila) 0.38106
VSTM4 V-set and transmembrane domain containing 4 0.376528
LIMCH1 LIM and calponin homology domains 1 0.370544
GFRA1 GDNF family receptor alpha 1 0.367064
CDKN2B-AS1 CDKN2B antisense RNA 1 0.36461
CHRM2 cholinergic receptor, muscarinic 2 0.36461
NSD1 nuclear receptor binding SET domain protein 1 0.362606
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 0.360941
BPIFC BPI fold containing family C 0.358325
TBXAS1 thromboxane A synthase 1 (platelet) 0.358325
NBEA neurobeachin 0.357225