middle ear Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The cavity in the temporal bone comprising the cavitas tympani, adnexa mastoidea, and tuba auditiva. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002099)
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Genes

280 proteins co-occuring with the tissue middle ear in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
A1BG alpha-1-B glycoprotein 1.69251
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.57013
FBXO11 F-box protein 11 1.46775
PATE1 prostate and testis expressed 1 1.46262
CD79A CD79a molecule, immunoglobulin-associated alpha 1.43524
HTRA3 HtrA serine peptidase 3 1.3823
COCH cochlin 1.28906
TUBE1 tubulin, epsilon 1 1.26128
LYZ lysozyme 1.20289
NOTCH1 notch 1 1.18645
IL1B interleukin 1, beta 1.18334
MUC19 mucin 19, oligomeric 1.15584
EYA1 EYA transcriptional coactivator and phosphatase 1 1.15185
PDZD11 PDZ domain containing 11 1.13412
TNF tumor necrosis factor 1.12438
HOXA2 homeobox A2 1.11553
EYA4 EYA transcriptional coactivator and phosphatase 4 1.10358
MUC2 mucin 2, oligomeric mucus/gel-forming 1.1027
MUC20 mucin 20, cell surface associated 1.08766
ALB albumin 1.05677
TSHZ1 teashirt zinc finger homeobox 1 1.04973
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 1.04796
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.00458
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 1.00327
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.994554
CRLF1 cytokine receptor-like factor 1 0.981953
MUC17 mucin 17, cell surface associated 0.966793
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.96636
CXCL8 chemokine (C-X-C motif) ligand 8 0.955134
MUC15 mucin 15, cell surface associated 0.95384
TLR2 toll-like receptor 2 0.951685
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 0.938347
MUC4 mucin 4, cell surface associated 0.935341
ECI1 enoyl-CoA delta isomerase 1 0.919488
C1QA complement component 1, q subcomponent, A chain 0.912653
DEFB123 defensin, beta 123 0.904553
MUC13 mucin 13, cell surface associated 0.899871
GJB2 gap junction protein, beta 2, 26kDa 0.880358
PLS1 plastin 1 0.869794
KRT10 keratin 10, type I 0.862206
RPL38 ribosomal protein L38 0.853788
PPBPP1 pro-platelet basic protein pseudogene 1 0.848745
DEFB4A defensin, beta 4A 0.847065
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 0.842867
CAPN14 calpain 14 0.841188
RNASE3 ribonuclease, RNase A family, 3 0.838672
MUC12 mucin 12, cell surface associated 0.834899
S100A7A S100 calcium binding protein A7A 0.832385
DEFB1 defensin, beta 1 0.829034
PGRMC1 progesterone receptor membrane component 1 0.82736
CLEC3A C-type lectin domain family 3, member A 0.811056
TCERG1L transcription elongation regulator 1-like 0.805213
ENO2 enolase 2 (gamma, neuronal) 0.784804
CLEC2B C-type lectin domain family 2, member B 0.782725
CLEC10A C-type lectin domain family 10, member A 0.779401
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 0.775664
RPS19 ribosomal protein S19 0.7711
POU3F4 POU class 3 homeobox 4 0.761984
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.758673
LTF lactotransferrin 0.743801
TLR4 toll-like receptor 4 0.737618
MUC1 mucin 1, cell surface associated 0.734323
KRT16 keratin 16, type I 0.717472
TAC1 tachykinin, precursor 1 0.712139
IL1A interleukin 1, alpha 0.700262
PRTN3 proteinase 3 0.692085
MUC7 mucin 7, secreted 0.674135
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.66925
EFS embryonal Fyn-associated substrate 0.668436
MSX1 msh homeobox 1 0.656648
IL6 interleukin 6 0.654212
SLITRK6 SLIT and NTRK-like family, member 6 0.651371
PPY pancreatic polypeptide 0.645695
MUC16 mucin 16, cell surface associated 0.642858
COL11A2 collagen, type XI, alpha 2 0.635572
SPRR1B small proline-rich protein 1B 0.633144
TBX1 T-box 1 0.630718
ICAM1 intercellular adhesion molecule 1 0.627485
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 0.610138
CHGA chromogranin A 0.609735
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.59646
TRIM37 tripartite motif containing 37 0.593649
COL11A2P1 collagen, type XI, alpha 2 pseudogene 1 0.592845
ALPPL2 alkaline phosphatase, placental-like 2 0.58322
ALPL alkaline phosphatase, liver/bone/kidney 0.58242
ALPP alkaline phosphatase, placental 0.581618
CKAP2 cytoskeleton associated protein 2 0.576816
HINT1 histidine triad nucleotide binding protein 1 0.576015
CTSB cathepsin B 0.575616
AMBP alpha-1-microglobulin/bikunin precursor 0.573616
FGF3 fibroblast growth factor 3 0.571619
CA10 carbonic anhydrase X 0.568823
DEFB103B defensin, beta 103B 0.566428
SOD2 superoxide dismutase 2, mitochondrial 0.560847
HAS1 hyaluronan synthase 1 0.54812
PLG plasminogen 0.545342
MUC6 mucin 6, oligomeric mucus/gel-forming 0.540981
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.539
GOSR2 golgi SNAP receptor complex member 2 0.537416
CALCA calcitonin-related polypeptide alpha 0.535833
SRRM2 serine/arginine repetitive matrix 2 0.529508
BMP8A bone morphogenetic protein 8a 0.525955
ACPP acid phosphatase, prostate 0.507849
IRG1 immunoresponsive 1 homolog (mouse) 0.507064
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.504318
TF transferrin 0.50275
HMX3 H6 family homeobox 3 0.50079
EGFR epidermal growth factor receptor 0.500398
AMER1 APC membrane recruitment protein 1 0.499223
SYP synaptophysin 0.49844
GTSE1 G-2 and S-phase expressed 1 0.495701
DPP7 dipeptidyl-peptidase 7 0.490229
KNG1 kininogen 1 0.488276
GDF6 growth differentiation factor 6 0.488276
MYD88 myeloid differentiation primary response 88 0.487886
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 0.487106
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.483596
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.482038
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 0.476201
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 0.474646
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 0.469599
TGIF1 TGFB-induced factor homeobox 1 0.464948
SELL selectin L 0.457214
HOXA1 homeobox A1 0.455284
TLR5 toll-like receptor 5 0.451428
CYLD cylindromatosis (turban tumor syndrome) 0.450271
CFP complement factor properdin 0.447961
NEUROD1 neuronal differentiation 1 0.444884
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.444499
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.436055
MNX1 motor neuron and pancreas homeobox 1 0.43146
BPI bactericidal/permeability-increasing protein 0.429547
KRT14 keratin 14, type I 0.428783
SPAG6 sperm associated antigen 6 0.424581
KRT6B keratin 6B, type II 0.423818
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.422292
FN1 fibronectin 1 0.420385
P3H1 prolyl 3-hydroxylase 1 0.418861
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 0.414673
GLA galactosidase, alpha 0.41087
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 0.398735
CD68 CD68 molecule 0.396844
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.394197
AQP5 aquaporin 5 0.387781
CMA1 chymase 1, mast cell 0.38665
MGP matrix Gla protein 0.383637
KRT4 keratin 4, type II 0.382884
KRT13 keratin 13, type I 0.382884
ANKH ANKH inorganic pyrophosphate transport regulator 0.382884
MCAM melanoma cell adhesion molecule 0.381755
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.381567
EREG epiregulin 0.377996
BMP4 bone morphogenetic protein 4 0.374243
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.369373
LAP3 leucine aminopeptidase 3 0.36825
SH3PXD2B SH3 and PX domains 2B 0.364886
FLG filaggrin 0.363579
MYO7A myosin VIIA 0.359664
PCNA proliferating cell nuclear antigen 0.35743
TSPO translocator protein (18kDa) 0.354826
NF2 neurofibromin 2 (merlin) 0.345188
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.344449
CD4 CD4 molecule 0.344079
TLR9 toll-like receptor 9 0.332661
BCAN brevican 0.330827
SMCP sperm mitochondria-associated cysteine-rich protein 0.330094
TP53 tumor protein p53 0.329361
PTGDR2 prostaglandin D2 receptor 2 0.328994
BMP10 bone morphogenetic protein 10 0.326432
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.325701
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.322414
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.318407
C5AR1 complement component 5a receptor 1 0.317679
KRT5 keratin 5, type II 0.316588
HSPA4 heat shock 70kDa protein 4 0.315498
ATOH1 atonal homolog 1 (Drosophila) 0.315135
PAX2 paired box 2 0.314409
MPO myeloperoxidase 0.31332
BMP2 bone morphogenetic protein 2 0.311507
IVL involucrin 0.309878
HAND2 heart and neural crest derivatives expressed 2 0.309697
FAM120A family with sequence similarity 120A 0.308612
KRT84 keratin 84, type II 0.307167
FGF7 fibroblast growth factor 7 0.305722
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.302478
PCP2 Purkinje cell protein 2 0.294939
AQP1 aquaporin 1 (Colton blood group) 0.293508
MMP3 matrix metallopeptidase 3 0.291008
CTSS cathepsin S 0.289939
NOD2 nucleotide-binding oligomerization domain containing 2 0.288514
FOXI1 forkhead box I1 0.288514
SIX1 SIX homeobox 1 0.283545
SZRD1 SUZ RNA binding domain containing 1 0.280717
GPX5 glutathione peroxidase 5 0.279659
MCPH1 microcephalin 1 0.277549
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 0.277197
NOD1 nucleotide-binding oligomerization domain containing 1 0.276145
GPX4 glutathione peroxidase 4 0.276145
CDH19 cadherin 19, type 2 0.275794
MIR21 microRNA 21 0.275269
BSND barttin CLCNK-type chloride channel accessory beta subunit 0.274394
AQP4 aquaporin 4 0.274045
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.272649
CFHR1 complement factor H-related 1 0.267102
GPX1 glutathione peroxidase 1 0.266069
PREP prolyl endopeptidase 0.25858
KIF1B kinesin family member 1B 0.25858
MMP25 matrix metallopeptidase 25 0.258243
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.257237
ERAS ES cell expressed Ras 0.254902
GDF7 growth differentiation factor 7 0.254902
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.25457
UBIAD1 UbiA prenyltransferase domain containing 1 0.252261
BTC betacellulin 0.251279
MAP2K3 mitogen-activated protein kinase kinase 3 0.251279
MMP9 matrix metallopeptidase 9 0.251279
MAN2B1 mannosidase, alpha, class 2B, member 1 0.250301
ALX4 ALX homeobox 4 0.250301
NID2 nidogen 2 (osteonidogen) 0.249653
POLB polymerase (DNA directed), beta 0.249006
B3GAT1 beta-1,3-glucuronyltransferase 1 0.239307
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 0.238706
TNC tenascin C 0.238706
CARD9 caspase recruitment domain family, member 9 0.23781
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.237513
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.233731
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.233446
DLX5 distal-less homeobox 5 0.232599
PPAN-P2RY11 PPAN-P2RY11 readthrough 0.232599
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 0.232599
LGALS7B lectin, galactoside-binding, soluble, 7B 0.232039
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.232039
DDN dendrin 0.230656
CD19 CD19 molecule 0.23011
KRTAP1-3 keratin associated protein 1-3 0.229032
REXO1L1P REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1, pseudogene 0.228764
FABP9 fatty acid binding protein 9, testis 0.227707
CCL4 chemokine (C-C motif) ligand 4 0.226411
JUN jun proto-oncogene 0.2259
BMP8B bone morphogenetic protein 8b 0.225647
KRTAP1-1 keratin associated protein 1-1 0.22415
FZD6 frizzled class receptor 6 0.221989
NOX3 NADPH oxidase 3 0.221755
C3 complement component 3 0.221521
TWIST1 twist family bHLH transcription factor 1 0.221291
COL11A1 collagen, type XI, alpha 1 0.221061
PDLIM7 PDZ and LIM domain 7 (enigma) 0.219485
DNASE1 deoxyribonuclease I 0.219264
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.21883
HEXB hexosaminidase B (beta polypeptide) 0.218292
PGLS 6-phosphogluconolactonase 0.217974
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.217346
CTNS cystinosin, lysosomal cystine transporter 0.217139
LGALS8 lectin, galactoside-binding, soluble, 8 0.214954
TPRG1L tumor protein p63 regulated 1-like 0.214765
MDH1 malate dehydrogenase 1, NAD (soluble) 0.214765
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.21365
THRA thyroid hormone receptor, alpha 0.212761
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.210369
FGFR2 fibroblast growth factor receptor 2 0.207147
PTEN phosphatase and tensin homolog 0.206775
KRT1 keratin 1, type II 0.203056
SLPI secretory leukocyte peptidase inhibitor 0.199444
HEXA hexosaminidase A (alpha polypeptide) 0.198247
BMP6 bone morphogenetic protein 6 0.197754
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.196973
TNS1 tensin 1 0.196569
ANXA2 annexin A2 0.195098
AREG amphiregulin 0.19504
ERBB4 erb-b2 receptor tyrosine kinase 4 0.194091
HMGA2 high mobility group AT-hook 2 0.194011
MKI67 marker of proliferation Ki-67 0.193387
F8 coagulation factor VIII, procoagulant component 0.19299
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.192808
MMP8 matrix metallopeptidase 8 0.192731
CTSK cathepsin K 0.1927
CTSL cathepsin L 0.192256
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.191177
HBEGF heparin-binding EGF-like growth factor 0.191159
ERBB3 erb-b2 receptor tyrosine kinase 3 0.190389