microprocessor complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs. (Gene Ontology, GO_0070877)
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32 proteins co-occuring with the microprocessor complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
DGCR8 DGCR8 microprocessor complex subunit 2.51432
DROSHA drosha, ribonuclease type III 2.28455
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 1.45194
DICER1 dicer 1, ribonuclease type III 1.30497
MIR21 microRNA 21 1.27877
XPO5 exportin 5 1.17106
TARBP1 TAR (HIV-1) RNA binding protein 1 1.15569
DCAF12 DDB1 and CUL4 associated factor 12 1.03378
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.783698
MIR22 microRNA 22 0.781412
AGO2 argonaute RISC catalytic component 2 0.768627
XRN2 5'-3' exoribonuclease 2 0.754076
PHAX phosphorylated adaptor for RNA export 0.732422
OXA1L oxidase (cytochrome c) assembly 1-like 0.723472
VMP1 vacuole membrane protein 1 0.668126
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.65388
NEUROG2 neurogenin 2 0.643572
FOXN1 forkhead box N1 0.591812
MIR146A microRNA 146a 0.588875
MIR145 microRNA 145 0.579251
TARBP2 TAR (HIV-1) RNA binding protein 2 0.539472
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.497015
HAT1 histone acetyltransferase 1 0.478038
ILF3 interleukin enhancer binding factor 3, 90kDa 0.451631
AGO1 argonaute RISC catalytic component 1 0.400527
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.37966
AIRE autoimmune regulator 0.353282
SMAD3 SMAD family member 3 0.32345
LRRK2 leucine-rich repeat kinase 2 0.276671
TARDBP TAR DNA binding protein 0.267139
RNASEH2A ribonuclease H2, subunit A 0.223497
ELAVL1 ELAV like RNA binding protein 1 0.196669