methyldopa-5637 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the methyldopa-5637 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACAA2 acetyl-CoA acyltransferase 2
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADARB1 adenosine deaminase, RNA-specific, B1
ARHGAP24 Rho GTPase activating protein 24
ARTN artemin
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BTG2 BTG family, member 2
C15ORF39 chromosome 15 open reading frame 39
C5ORF42 chromosome 5 open reading frame 42
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CDC14B cell division cycle 14B
CDHR2 cadherin-related family member 2
CDK13 cyclin-dependent kinase 13
CFHR2 complement factor H-related 2
CFHR4 complement factor H-related 4
CLCN7 chloride channel, voltage-sensitive 7
CLTA clathrin, light chain A
COL2A1 collagen, type II, alpha 1
COL4A2 collagen, type IV, alpha 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DGKQ diacylglycerol kinase, theta 110kDa
DMPK dystrophia myotonica-protein kinase
DMRT1 doublesex and mab-3 related transcription factor 1
ESR1 estrogen receptor 1
EVI5 ecotropic viral integration site 5
FAM46C family with sequence similarity 46, member C
FAM76A family with sequence similarity 76, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGF13 fibroblast growth factor 13
GAS7 growth arrest-specific 7
GK glycerol kinase
GOLGA8A golgin A8 family, member A
GRIK1 glutamate receptor, ionotropic, kainate 1
GSK3A glycogen synthase kinase 3 alpha
HFE hemochromatosis
HOXB3 homeobox B3
HOXD9 homeobox D9
IFT27 intraflagellar transport 27
IGLJ3 immunoglobulin lambda joining 3
IL1RN interleukin 1 receptor antagonist
INHBE inhibin, beta E
IZUMO4 IZUMO family member 4
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KHK ketohexokinase (fructokinase)
KLK13 kallikrein-related peptidase 13
KRT8 keratin 8, type II
LARP4B La ribonucleoprotein domain family, member 4B
LENEP lens epithelial protein
MAOB monoamine oxidase B
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIER2 mesoderm induction early response 1, family member 2
MMP25 matrix metallopeptidase 25
MNDA myeloid cell nuclear differentiation antigen
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NKX2-8 NK2 homeobox 8
NPAS2 neuronal PAS domain protein 2
PCDH11Y protocadherin 11 Y-linked
PDIA2 protein disulfide isomerase family A, member 2
PEG3 paternally expressed 3
PLLP plasmolipin
PLXNC1 plexin C1
PPP1R37 protein phosphatase 1, regulatory subunit 37
PRR16 proline rich 16
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PYY peptide YY
RAB3B RAB3B, member RAS oncogene family
RXRB retinoid X receptor, beta
SHOX2 short stature homeobox 2
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPPL2B signal peptide peptidase like 2B
SPRR2B small proline-rich protein 2B
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAPBP TAP binding protein (tapasin)
TBC1D22A TBC1 domain family, member 22A
TBX3 T-box 3
TMEM212 transmembrane protein 212
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
UBQLN4 ubiquilin 4
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VEGFB vascular endothelial growth factor B
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZC3H3 zinc finger CCCH-type containing 3
ZFP64 ZFP64 zinc finger protein
ZNF442 zinc finger protein 442
ZNF682 zinc finger protein 682

decreased expression

Symbol Name
ADAMTSL3 ADAMTS-like 3
ADTRP androgen-dependent TFPI-regulating protein
APOLD1 apolipoprotein L domain containing 1
AUTS2 autism susceptibility candidate 2
BATF basic leucine zipper transcription factor, ATF-like
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BMP4 bone morphogenetic protein 4
C14ORF93 chromosome 14 open reading frame 93
C2ORF27A chromosome 2 open reading frame 27A
C8ORF60 chromosome 8 open reading frame 60
CCDC134 coiled-coil domain containing 134
CCDC71 coiled-coil domain containing 71
CD79B CD79b molecule, immunoglobulin-associated beta
CES3 carboxylesterase 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLGN calmegin
CNGB3 cyclic nucleotide gated channel beta 3
CRY2 cryptochrome circadian clock 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYSF dysferlin
EFNA3 ephrin-A3
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EPX eosinophil peroxidase
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
F2R coagulation factor II (thrombin) receptor
FADS2 fatty acid desaturase 2
FAM204A family with sequence similarity 204, member A
FILIP1L filamin A interacting protein 1-like
FLJ21369 uncharacterized protein FLJ21369
GFI1 growth factor independent 1 transcription repressor
GJA9 gap junction protein, alpha 9, 59kDa
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GRAMD1C GRAM domain containing 1C
HDAC11 histone deacetylase 11
HDAC5 histone deacetylase 5
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMHB1 histocompatibility (minor) HB-1
HOXC8 homeobox C8
HSPA1L heat shock 70kDa protein 1-like
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYI hydroxypyruvate isomerase (putative)
IBSP integrin-binding sialoprotein
IL12RB1 interleukin 12 receptor, beta 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INO80D INO80 complex subunit D
ITGA8 integrin, alpha 8
KCTD7 potassium channel tetramerization domain containing 7
KIF13B kinesin family member 13B
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC100286895 cell division cycle 27 homolog pseudogene
MAL mal, T-cell differentiation protein
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
MUC3A mucin 3A, cell surface associated
MYO1F myosin IF
NACA2 nascent polypeptide-associated complex alpha subunit 2
NEUROD1 neuronal differentiation 1
NEUROD4 neuronal differentiation 4
NOD1 nucleotide-binding oligomerization domain containing 1
NPTX1 neuronal pentraxin I
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PADI1 peptidyl arginine deiminase, type I
PDE8B phosphodiesterase 8B
PLA2G3 phospholipase A2, group III
PLEKHO2 pleckstrin homology domain containing, family O member 2
POU4F2 POU class 4 homeobox 2
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
RAB30 RAB30, member RAS oncogene family
RFXAP regulatory factor X-associated protein
RHOBTB2 Rho-related BTB domain containing 2
RNF39 ring finger protein 39
RNF43 ring finger protein 43
RPL10L ribosomal protein L10-like
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SLPI secretory leukocyte peptidase inhibitor
SNX15 sorting nexin 15
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SULT4A1 sulfotransferase family 4A, member 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAS2R10 taste receptor, type 2, member 10
TBX19 T-box 19
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TGFBR3 transforming growth factor, beta receptor III
TMEM242 transmembrane protein 242
TMPRSS3 transmembrane protease, serine 3
VIPR1 vasoactive intestinal peptide receptor 1
VN1R1 vomeronasal 1 receptor 1
XDH xanthine dehydrogenase
ZBTB33 zinc finger and BTB domain containing 33
ZBTB44 zinc finger and BTB domain containing 44
ZFP37 ZFP37 zinc finger protein
ZNF484 zinc finger protein 484
ZNF711 zinc finger protein 711