methylbenzethonium chloride-3768 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the methylbenzethonium chloride-3768 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ACE angiotensin I converting enzyme
ACSL5 acyl-CoA synthetase long-chain family member 5
AGTR1 angiotensin II receptor, type 1
ALDOB aldolase B, fructose-bisphosphate
APAF1 apoptotic peptidase activating factor 1
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BMP10 bone morphogenetic protein 10
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN1 claudin 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DMBT1 deleted in malignant brain tumors 1
DUSP1 dual specificity phosphatase 1
EFNB3 ephrin-B3
EGR1 early growth response 1
FAM13C family with sequence similarity 13, member C
FGF18 fibroblast growth factor 18
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GIPC2 GIPC PDZ domain containing family, member 2
GLRA2 glycine receptor, alpha 2
GP6 glycoprotein VI (platelet)
GPR182 G protein-coupled receptor 182
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRM7 glutamate receptor, metabotropic 7
GSTTP1 glutathione S-transferase theta pseudogene 1
HEG1 heart development protein with EGF-like domains 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDS iduronate 2-sulfatase
IGF2-AS IGF2 antisense RNA
IL11 interleukin 11
IL1RL1 interleukin 1 receptor-like 1
IL32 interleukin 32
ING4 inhibitor of growth family, member 4
ITGA9 integrin, alpha 9
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KIF25 kinesin family member 25
KLHL24 kelch-like family member 24
KRT16 keratin 16, type I
KRT17 keratin 17, type I
LEF1 lymphoid enhancer-binding factor 1
MBNL2 muscleblind-like splicing regulator 2
MPL MPL proto-oncogene, thrombopoietin receptor
MT1M metallothionein 1M
MYBPC3 myosin binding protein C, cardiac
NECAB2 N-terminal EF-hand calcium binding protein 2
NKX2-5 NK2 homeobox 5
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRCAM neuronal cell adhesion molecule
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PDLIM3 PDZ and LIM domain 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PRB4 proline-rich protein BstNI subfamily 4
PRDM1 PR domain containing 1, with ZNF domain
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PYY peptide YY
RAB6B RAB6B, member RAS oncogene family
RBBP9 retinoblastoma binding protein 9
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RGS4 regulator of G-protein signaling 4
SAA3P serum amyloid A3 pseudogene
SAMD4A sterile alpha motif domain containing 4A
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SEZ6L seizure related 6 homolog (mouse)-like
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
SULT4A1 sulfotransferase family 4A, member 1
TAT tyrosine aminotransferase
TEC tec protein tyrosine kinase
TEF thyrotrophic embryonic factor
TGFBR1 transforming growth factor, beta receptor 1
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIB3 tribbles pseudokinase 3
TRIM10 tripartite motif containing 10
TRIM3 tripartite motif containing 3
TRPM1 transient receptor potential cation channel, subfamily M, member 1
USH1C Usher syndrome 1C (autosomal recessive, severe)
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADTRP androgen-dependent TFPI-regulating protein
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARMC6 armadillo repeat containing 6
ARMCX2 armadillo repeat containing, X-linked 2
ASAP1-IT1 ASAP1 intronic transcript 1
ASB13 ankyrin repeat and SOCS box containing 13
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BSPRY B-box and SPRY domain containing
C9ORF40 chromosome 9 open reading frame 40
CCDC25 coiled-coil domain containing 25
CCDC51 coiled-coil domain containing 51
CCDC85C coiled-coil domain containing 85C
CFAP44 cilia and flagella associated protein 44
CHMP6 charged multivesicular body protein 6
CHRM3 cholinergic receptor, muscarinic 3
CLDN11 claudin 11
CLSPN claspin
CNTLN centlein, centrosomal protein
CUTC cutC copper transporter
DCAF4 DDB1 and CUL4 associated factor 4
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DUSP9 dual specificity phosphatase 9
ERCC5 excision repair cross-complementation group 5
FAM114A2 family with sequence similarity 114, member A2
FGGY FGGY carbohydrate kinase domain containing
FKBPL FK506 binding protein like
FZD3 frizzled class receptor 3
GALT galactose-1-phosphate uridylyltransferase
GLDC glycine dehydrogenase (decarboxylating)
GPALPP1 GPALPP motifs containing 1
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXA2 homeobox A2
HOXB13 homeobox B13
HOXC10 homeobox C10
IL17RB interleukin 17 receptor B
LPAR6 lysophosphatidic acid receptor 6
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MANSC1 MANSC domain containing 1
MX1 MX dynamin-like GTPase 1
NDP Norrie disease (pseudoglioma)
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NHLRC2 NHL repeat containing 2
NLRX1 NLR family member X1
NOTCH1 notch 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PALMD palmdelphin
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLK1 polo-like kinase 1
PMCH pro-melanin-concentrating hormone
POLM polymerase (DNA directed), mu
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRU protein tyrosine phosphatase, receptor type, U
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIPPLY3 ripply transcriptional repressor 3
RPL23AP32 ribosomal protein L23a pseudogene 32
SAYSD1 SAYSVFN motif domain containing 1
SELENBP1 selenium binding protein 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SNORA21 small nucleolar RNA, H/ACA box 21
SPRYD7 SPRY domain containing 7
SUSD4 sushi domain containing 4
SYTL2 synaptotagmin-like 2
TACC3 transforming, acidic coiled-coil containing protein 3
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
THOP1 thimet oligopeptidase 1
TOE1 target of EGR1, member 1 (nuclear)
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSC22D4 TSC22 domain family, member 4
TTC30A tetratricopeptide repeat domain 30A
TWISTNB TWIST neighbor
USB1 U6 snRNA biogenesis 1
WDR25 WD repeat domain 25
WNT7A wingless-type MMTV integration site family, member 7A
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XYLT2 xylosyltransferase II
ZNF219 zinc finger protein 219
ZNF239 zinc finger protein 239
ZNF254 zinc finger protein 254
ZNF37BP zinc finger protein 37B, pseudogene
ZNF571 zinc finger protein 571
ZNF573 zinc finger protein 573
ZNRD1-AS1 ZNRD1 antisense RNA 1