methacholine chloride-6248 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the methacholine chloride-6248 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACTC1 actin, alpha, cardiac muscle 1
ALS2CL ALS2 C-terminal like
ANK1 ankyrin 1, erythrocytic
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARSB arylsulfatase B
ATXN2L ataxin 2-like
BAAT bile acid CoA:amino acid N-acyltransferase
BCAP29 B-cell receptor-associated protein 29
BIN1 bridging integrator 1
C14ORF93 chromosome 14 open reading frame 93
C17ORF53 chromosome 17 open reading frame 53
C4BPA complement component 4 binding protein, alpha
CALD1 caldesmon 1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD300A CD300a molecule
CD52 CD52 molecule
CD6 CD6 molecule
CD83 CD83 molecule
CEP97 centrosomal protein 97kDa
CFAP45 cilia and flagella associated protein 45
CFAP69 cilia and flagella associated protein 69
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCN6 chloride channel, voltage-sensitive 6
CLDN17 claudin 17
CNTNAP2 contactin associated protein-like 2
COL6A1 collagen, type VI, alpha 1
CRELD1 cysteine-rich with EGF-like domains 1
CRLF1 cytokine receptor-like factor 1
CTIF CBP80/20-dependent translation initiation factor
CXORF21 chromosome X open reading frame 21
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DMC1 DNA meiotic recombinase 1
DUSP13 dual specificity phosphatase 13
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EMC3 ER membrane protein complex subunit 3
EPB41L1 erythrocyte membrane protein band 4.1-like 1
ESRRA estrogen-related receptor alpha
FAIM2 Fas apoptotic inhibitory molecule 2
FBXL15 F-box and leucine-rich repeat protein 15
FILIP1L filamin A interacting protein 1-like
FRMD4A FERM domain containing 4A
GPC3 glypican 3
GPR4 G protein-coupled receptor 4
HGD homogentisate 1,2-dioxygenase
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXC8 homeobox C8
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL27RA interleukin 27 receptor, alpha
ITGA10 integrin, alpha 10
LAMA4 laminin, alpha 4
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP2K2 mitogen-activated protein kinase kinase 2
MAP4 microtubule-associated protein 4
METTL7A methyltransferase like 7A
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MON2 MON2 homolog (S. cerevisiae)
NDRG2 NDRG family member 2
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NIPAL2 NIPA-like domain containing 2
NPR2 natriuretic peptide receptor 2
NPR3 natriuretic peptide receptor 3
NPY2R neuropeptide Y receptor Y2
PARVB parvin, beta
PCGF2 polycomb group ring finger 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PIDD1 p53-induced death domain protein 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCE1 phospholipase C, epsilon 1
PLK3 polo-like kinase 3
PRF1 perforin 1 (pore forming protein)
PRPF18 pre-mRNA processing factor 18
RAB11B RAB11B, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SGK1 serum/glucocorticoid regulated kinase 1
SGSM3 small G protein signaling modulator 3
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMC1A structural maintenance of chromosomes 1A
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SP100 SP100 nuclear antigen
SPTAN1 spectrin, alpha, non-erythrocytic 1
STK17B serine/threonine kinase 17b
TBXA2R thromboxane A2 receptor
THRB thyroid hormone receptor, beta
TICAM1 toll-like receptor adaptor molecule 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM206 transmembrane protein 206
TP53I11 tumor protein p53 inducible protein 11
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UTRN utrophin
VIPR2 vasoactive intestinal peptide receptor 2
ZFP37 ZFP37 zinc finger protein

decreased expression

Symbol Name
ACYP2 acylphosphatase 2, muscle type
AEN apoptosis enhancing nuclease
AHR aryl hydrocarbon receptor
ARHGAP12 Rho GTPase activating protein 12
ARID4A AT rich interactive domain 4A (RBP1-like)
ARRB2 arrestin, beta 2
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD3A ATPase family, AAA domain containing 3A
C17ORF85 chromosome 17 open reading frame 85
CCDC170 coiled-coil domain containing 170
CCDC6 coiled-coil domain containing 6
CDKN2AIP CDKN2A interacting protein
CEP85 centrosomal protein 85kDa
CFD complement factor D (adipsin)
CHUK conserved helix-loop-helix ubiquitous kinase
CLDN15 claudin 15
COL4A5 collagen, type IV, alpha 5
CORO1A coronin, actin binding protein, 1A
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DNAAF2 dynein, axonemal, assembly factor 2
ECHDC3 enoyl CoA hydratase domain containing 3
EDC3 enhancer of mRNA decapping 3
EDC4 enhancer of mRNA decapping 4
EGLN3 egl-9 family hypoxia-inducible factor 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM134C family with sequence similarity 134, member C
FGGY FGGY carbohydrate kinase domain containing
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
FOXJ2 forkhead box J2
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GCC2 GRIP and coiled-coil domain containing 2
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPALPP1 GPALPP motifs containing 1
GRAMD3 GRAM domain containing 3
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HCFC2 host cell factor C2
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
ILKAP integrin-linked kinase-associated serine/threonine phosphatase
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IRF6 interferon regulatory factor 6
L2HGDH L-2-hydroxyglutarate dehydrogenase
LINC00339 long intergenic non-protein coding RNA 339
LMNB1 lamin B1
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAPK3 mitogen-activated protein kinase 3
MCRS1 microspherule protein 1
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MSX1 msh homeobox 1
NCAPD3 non-SMC condensin II complex, subunit D3
NOL6 nucleolar protein 6 (RNA-associated)
NXN nucleoredoxin
PIKFYVE phosphoinositide kinase, FYVE finger containing
PQLC1 PQ loop repeat containing 1
PROCR protein C receptor, endothelial
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PYGB phosphorylase, glycogen; brain
RAI14 retinoic acid induced 14
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBL1 retinoblastoma-like 1
RBM41 RNA binding motif protein 41
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGS19 regulator of G-protein signaling 19
RPIA ribose 5-phosphate isomerase A
SDAD1 SDA1 domain containing 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC25A40 solute carrier family 25, member 40
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNIP1 Smad nuclear interacting protein 1
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TDP1 tyrosyl-DNA phosphodiesterase 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM260 transmembrane protein 260
TMOD3 tropomodulin 3 (ubiquitous)
TMSB15B thymosin beta 15B
TPST2 tyrosylprotein sulfotransferase 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC11 trafficking protein particle complex 11
TRAPPC2 trafficking protein particle complex 2
TRIM25 tripartite motif containing 25
TRIM62 tripartite motif containing 62
TSPYL2 TSPY-like 2
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WRN Werner syndrome, RecQ helicase-like
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF250 zinc finger protein 250
ZNF273 zinc finger protein 273
ZNF280D zinc finger protein 280D
ZNF282 zinc finger protein 282
ZNF552 zinc finger protein 552
ZNF586 zinc finger protein 586