methacholine chloride-5773 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the methacholine chloride-5773 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACSS3 acyl-CoA synthetase short-chain family member 3
ACVR1B activin A receptor, type IB
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ALPK1 alpha-kinase 1
AMPD1 adenosine monophosphate deaminase 1
ARNT aryl hydrocarbon receptor nuclear translocator
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BTN3A2 butyrophilin, subfamily 3, member A2
CALD1 caldesmon 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCDC40 coiled-coil domain containing 40
CCDC85C coiled-coil domain containing 85C
CCNT2 cyclin T2
CDHR2 cadherin-related family member 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHN2 chimerin 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CROCC ciliary rootlet coiled-coil, rootletin
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTBP2 C-terminal binding protein 2
CTNS cystinosin, lysosomal cystine transporter
DESI2 desumoylating isopeptidase 2
DNAAF1 dynein, axonemal, assembly factor 1
DOCK9 dedicator of cytokinesis 9
DUOX2 dual oxidase 2
EMID1 EMI domain containing 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FILIP1L filamin A interacting protein 1-like
GPR85 G protein-coupled receptor 85
GPX3 glutathione peroxidase 3
GRM1 glutamate receptor, metabotropic 1
GUSBP3 glucuronidase, beta pseudogene 3
HPCAL4 hippocalcin like 4
HSPB11 heat shock protein family B (small), member 11
IL12B interleukin 12B
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCTD14 potassium channel tetramerization domain containing 14
KRT17 keratin 17, type I
KYNU kynureninase
LDAH lipid droplet associated hydrolase
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMTK2 lemur tyrosine kinase 2
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LTB4R leukotriene B4 receptor
NCR2 natural cytotoxicity triggering receptor 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NOVA1 neuro-oncological ventral antigen 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OGDHL oxoglutarate dehydrogenase-like
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PAPOLA poly(A) polymerase alpha
PDE10A phosphodiesterase 10A
PGBD5 piggyBac transposable element derived 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP prolactin-induced protein
PLCB2 phospholipase C, beta 2
PLD1 phospholipase D1, phosphatidylcholine-specific
PLK3 polo-like kinase 3
PLK4 polo-like kinase 4
PNMAL1 paraneoplastic Ma antigen family-like 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRB4 proline-rich protein BstNI subfamily 4
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RANBP1 RAN binding protein 1
RASL11B RAS-like, family 11, member B
RBM26 RNA binding motif protein 26
REPS1 RALBP1 associated Eps domain containing 1
RET ret proto-oncogene
RGS5 regulator of G-protein signaling 5
S100A13 S100 calcium binding protein A13
SCN10A sodium channel, voltage gated, type X alpha subunit
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SH2B1 SH2B adaptor protein 1
SHOX2 short stature homeobox 2
SIGLEC6 sialic acid binding Ig-like lectin 6
SOCS3 suppressor of cytokine signaling 3
SPAG8 sperm associated antigen 8
STK17A serine/threonine kinase 17a
SULF1 sulfatase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TACR1 tachykinin receptor 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TCP10 t-complex 10
TIMELESS timeless circadian clock
TMEM19 transmembrane protein 19
TMEM206 transmembrane protein 206
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TP53I11 tumor protein p53 inducible protein 11
TPSAB1 tryptase alpha/beta 1
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
ZNF224 zinc finger protein 224

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMT aminomethyltransferase
ANXA2P1 annexin A2 pseudogene 1
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGAP24 Rho GTPase activating protein 24
ARMC6 armadillo repeat containing 6
C11ORF80 chromosome 11 open reading frame 80
CCNA1 cyclin A1
CD82 CD82 molecule
CDK6 cyclin-dependent kinase 6
CDKL3 cyclin-dependent kinase-like 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEMIP cell migration inducing protein, hyaluronan binding
CINP cyclin-dependent kinase 2 interacting protein
CISH cytokine inducible SH2-containing protein
CLEC2B C-type lectin domain family 2, member B
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COBL cordon-bleu WH2 repeat protein
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DDN dendrin
DOCK1 dedicator of cytokinesis 1
EGR2 early growth response 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM50B family with sequence similarity 50, member B
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GRTP1 growth hormone regulated TBC protein 1
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HSPA1L heat shock 70kDa protein 1-like
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
IFNA14 interferon, alpha 14
IFNA17 interferon, alpha 17
ISYNA1 inositol-3-phosphate synthase 1
ITGA10 integrin, alpha 10
JUNB jun B proto-oncogene
KRT15 keratin 15, type I
LIMS2 LIM and senescent cell antigen-like domains 2
LIPG lipase, endothelial
LYPD3 LY6/PLAUR domain containing 3
MAGEF1 melanoma antigen family F1
MAN2C1 mannosidase, alpha, class 2C, member 1
MANBA mannosidase, beta A, lysosomal
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MTA2 metastasis associated 1 family, member 2
MYL5 myosin, light chain 5, regulatory
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NOL6 nucleolar protein 6 (RNA-associated)
NPFFR1 neuropeptide FF receptor 1
PAQR6 progestin and adipoQ receptor family member VI
PC pyruvate carboxylase
PHEX phosphate regulating endopeptidase homolog, X-linked
PLA2G15 phospholipase A2, group XV
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POMT2 protein-O-mannosyltransferase 2
PRPH peripherin
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
R3HCC1L R3H domain and coiled-coil containing 1-like
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGCC regulator of cell cycle
RNF39 ring finger protein 39
SCIN scinderin
SDC3 syndecan 3
SFT2D2 SFT2 domain containing 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMAD7 SMAD family member 7
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPAG4 sperm associated antigen 4
SPRYD7 SPRY domain containing 7
STAG3 stromal antigen 3
STARD3 StAR-related lipid transfer (START) domain containing 3
STK16 serine/threonine kinase 16
TAGLN transgelin
TENM4 teneurin transmembrane protein 4
TMEM121 transmembrane protein 121
TMEM212 transmembrane protein 212
TRAPPC6A trafficking protein particle complex 6A
TRIM25 tripartite motif containing 25
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTLL7 tubulin tyrosine ligase-like family member 7
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VWA1 von Willebrand factor A domain containing 1
WDR4 WD repeat domain 4
WNT7A wingless-type MMTV integration site family, member 7A
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF141 zinc finger protein 141
ZNF205 zinc finger protein 205
ZNF324 zinc finger protein 324
ZNF350 zinc finger protein 350
ZNF358 zinc finger protein 358
ZNF668 zinc finger protein 668
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768