methacholine chloride-3452 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the methacholine chloride-3452 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ALPK1 alpha-kinase 1
APOM apolipoprotein M
ARL4C ADP-ribosylation factor-like 4C
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BAIAP2 BAI1-associated protein 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1QTNF3 C1q and tumor necrosis factor related protein 3
CACYBP calcyclin binding protein
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC186 coiled-coil domain containing 186
CD40 CD40 molecule, TNF receptor superfamily member 5
CEP164 centrosomal protein 164kDa
CFHR4 complement factor H-related 4
CFLAR CASP8 and FADD-like apoptosis regulator
CLIC2 chloride intracellular channel 2
CNN2 calponin 2
COBL cordon-bleu WH2 repeat protein
COL6A1 collagen, type VI, alpha 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAKD dephospho-CoA kinase domain containing
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNPEP aspartyl aminopeptidase
DUSP6 dual specificity phosphatase 6
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EPOR erythropoietin receptor
ERCC4 excision repair cross-complementation group 4
F2R coagulation factor II (thrombin) receptor
FAM63B family with sequence similarity 63, member B
FGD1 FYVE, RhoGEF and PH domain containing 1
FILIP1L filamin A interacting protein 1-like
FPGS folylpolyglutamate synthase
GAMT guanidinoacetate N-methyltransferase
GAS7 growth arrest-specific 7
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPR182 G protein-coupled receptor 182
GREB1 growth regulation by estrogen in breast cancer 1
HFE hemochromatosis
HIST1H3J histone cluster 1, H3j
ICOSLG inducible T-cell co-stimulator ligand
IDS iduronate 2-sulfatase
IGFBP5 insulin-like growth factor binding protein 5
IQCC IQ motif containing C
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAG1 jagged 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLHL25 kelch-like family member 25
LAMP1 lysosomal-associated membrane protein 1
LDB1 LIM domain binding 1
LINC00341 long intergenic non-protein coding RNA 341
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MED18 mediator complex subunit 18
MEFV Mediterranean fever
METTL7A methyltransferase like 7A
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCALD neurocalcin delta
NFIB nuclear factor I/B
NGLY1 N-glycanase 1
NRF1 nuclear respiratory factor 1
PAX5 paired box 5
PDE2A phosphodiesterase 2A, cGMP-stimulated
PER3 period circadian clock 3
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLEKHS1 pleckstrin homology domain containing, family S member 1
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POU2F3 POU class 2 homeobox 3
PRKCE protein kinase C, epsilon
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PVR poliovirus receptor
RAD52 RAD52 homolog (S. cerevisiae)
RETN resistin
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RREB1 ras responsive element binding protein 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SAMD4A sterile alpha motif domain containing 4A
SFTPA2 surfactant protein A2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SMTN smoothelin
SOCS1 suppressor of cytokine signaling 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
TCHH trichohyalin
THBS3 thrombospondin 3
TMEM63A transmembrane protein 63A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM36 tripartite motif containing 36
VPS13B vacuolar protein sorting 13 homolog B (yeast)
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB43 zinc finger and BTB domain containing 43
ZMYND8 zinc finger, MYND-type containing 8
ZNF428 zinc finger protein 428
ZNF652 zinc finger protein 652
ZNF778 zinc finger protein 778
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADM adrenomedullin
AGO1 argonaute RISC catalytic component 1
ALDOC aldolase C, fructose-bisphosphate
ALS2CL ALS2 C-terminal like
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARMC6 armadillo repeat containing 6
ATAD5 ATPase family, AAA domain containing 5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAG4 BCL2-associated athanogene 4
BGLAP bone gamma-carboxyglutamate (gla) protein
BIK BCL2-interacting killer (apoptosis-inducing)
BRAF B-Raf proto-oncogene, serine/threonine kinase
C10ORF88 chromosome 10 open reading frame 88
C11ORF80 chromosome 11 open reading frame 80
C12ORF4 chromosome 12 open reading frame 4
C5AR2 complement component 5a receptor 2
CA11 carbonic anhydrase XI
CAPN15 calpain 15
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CCP110 centriolar coiled coil protein 110kDa
CDKN2AIP CDKN2A interacting protein
CLK1 CDC-like kinase 1
CLSPN claspin
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
DEAF1 DEAF1 transcription factor
EFHC1 EF-hand domain (C-terminal) containing 1
ELMO3 engulfment and cell motility 3
FAM131A family with sequence similarity 131, member A
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GPR87 G protein-coupled receptor 87
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HDAC4 histone deacetylase 4
HINFP histone H4 transcription factor
HIST1H2AI histone cluster 1, H2ai
HLA-J major histocompatibility complex, class I, J (pseudogene)
HSPA1L heat shock 70kDa protein 1-like
IRF6 interferon regulatory factor 6
JUNB jun B proto-oncogene
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0355 KIAA0355
KIAA0513 KIAA0513
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMBR1L limb development membrane protein 1-like
LOC257152 uncharacterized LOC257152
LZTFL1 leucine zipper transcription factor-like 1
MBNL3 muscleblind-like splicing regulator 3
MICALL2 MICAL-like 2
MT1H metallothionein 1H
NDE1 nudE neurodevelopment protein 1
NIPAL2 NIPA-like domain containing 2
NT5DC3 5'-nucleotidase domain containing 3
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARD6A par-6 family cell polarity regulator alpha
PARP12 poly (ADP-ribose) polymerase family, member 12
PARP16 poly (ADP-ribose) polymerase family, member 16
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHGDH phosphoglycerate dehydrogenase
PITX2 paired-like homeodomain 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PODXL podocalyxin-like
PROS1 protein S (alpha)
RAB30 RAB30, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RASAL1 RAS protein activator like 1 (GAP1 like)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF141 ring finger protein 141
RNF38 ring finger protein 38
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A14 solute carrier family 22, member 14
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPINK4 serine peptidase inhibitor, Kazal type 4
SRD5A3 steroid 5 alpha-reductase 3
SREK1IP1 SREK1-interacting protein 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STRN striatin, calmodulin binding protein
TADA2A transcriptional adaptor 2A
TBC1D19 TBC1 domain family, member 19
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGIF1 TGFB-induced factor homeobox 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TRIM13 tripartite motif containing 13
TSPYL2 TSPY-like 2
TWSG1 twisted gastrulation BMP signaling modulator 1
UBQLN4 ubiquilin 4
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZNF205 zinc finger protein 205
ZNF219 zinc finger protein 219
ZNF32 zinc finger protein 32
ZNF668 zinc finger protein 668
ZSCAN31 zinc finger and SCAN domain containing 31