metabolic syndrome x Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_14221)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:14221
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Genes

119 genes associated with the disease metabolic syndrome x in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
CDH13 cadherin 13 3.32224
APOC1 apolipoprotein C-I 3.24373
HNF1A HNF1 homeobox A 3.18496
IL6R interleukin 6 receptor 2.53877
ADIPOQ adiponectin, C1Q and collagen domain containing 2.48617
GCKR glucokinase (hexokinase 4) regulator 2.42713
CRP C-reactive protein, pentraxin-related 2.22046
G6PC2 glucose-6-phosphatase, catalytic, 2 2.17065
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.05547
CMIP c-Maf inducing protein 2.05009
APOE apolipoprotein E 2.03162
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 2.00817
LPL lipoprotein lipase 1.8787
ZPR1 ZPR1 zinc finger 1.8787
TIMP2 TIMP metallopeptidase inhibitor 2 1.87707
APOA5 apolipoprotein A-V 1.86468
BUD13 BUD13 homolog (S. cerevisiae) 1.84079
NLRP3 NLR family, pyrin domain containing 3 1.83309
LEPR leptin receptor 1.76581
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 1.74
PBRM1 polybromo 1 1.7256
LOC157273 uncharacterized LOC157273 1.71806
PEPD peptidase D 1.6622
CETP cholesteryl ester transfer protein, plasma 1.64762
MLXIPL MLX interacting protein-like 1.62029
DOCK4 dedicator of cytokinesis 4 1.5865
CAMK2B calcium/calmodulin-dependent protein kinase II beta 1.57873
APOB apolipoprotein B 1.57556
TREM2 triggering receptor expressed on myeloid cells 2 1.57556
EDC4 enhancer of mRNA decapping 4 1.55738
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 1.54533
OASL 2'-5'-oligoadenylate synthetase-like 1.54329
FAM107A family with sequence similarity 107, member A 1.52922
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.52524
GPN1 GPN-loop GTPase 1 1.50906
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.50906
C12ORF43 chromosome 12 open reading frame 43 1.50154
C2ORF16 chromosome 2 open reading frame 16 1.48714
HNF4A hepatocyte nuclear factor 4, alpha 1.48714
KNG1 kininogen 1 1.48714
FTO fat mass and obesity associated 1.48714
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 1.47528
RORA RAR-related orphan receptor A 1.46277
BCL7B B-cell CLL/lymphoma 7B 1.46277
ZNF512 zinc finger protein 512 1.45471
ANKRD28 ankyrin repeat domain 28 1.4132
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 1.39984
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.39396
LOC100506403 uncharacterized LOC100506403 1.39396
ARL15 ADP-ribosylation factor-like 15 1.37327
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 1.35834
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 1.35834
GPRC6A G protein-coupled receptor, class C, group 6, member A 1.34719
FSTL4 follistatin-like 4 1.33656
NCOA5 nuclear receptor coactivator 5 1.32976
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.32087
C9ORF3 chromosome 9 open reading frame 3 1.32011
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 1.31635
ZNF664 zinc finger protein 664 1.28906
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 1.28689
FADS2 fatty acid desaturase 2 1.25477
TMEM258 transmembrane protein 258 1.23034
FADS1 fatty acid desaturase 1 1.23034
EIF4A2 eukaryotic translation initiation factor 4A2 1.21996
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 1.21996
KIAA1217 KIAA1217 1.16953
LRP1B low density lipoprotein receptor-related protein 1B 1.1572
DLG4 discs, large homolog 4 (Drosophila) 1.14463
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 1.10764
BTBD11 BTB (POZ) domain containing 11 1.08731
OFCC1 orofacial cleft 1 candidate 1 1.07599
PQLC1 PQ loop repeat containing 1 1.06405
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 1.05629
RGS6 regulator of G-protein signaling 6 1.04846
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 1.02476
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 1.02476
LDLRAD4 low density lipoprotein receptor class A domain containing 4 1.01348
TTC7B tetratricopeptide repeat domain 7B 1.00672
SYN3 synapsin III 1.00577
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1.00407
PDE3B phosphodiesterase 3B, cGMP-inhibited 1.00407
RBMS2 RNA binding motif, single stranded interacting protein 2 0.986376
LYRM4 LYR motif containing 4 0.980166
METTL11B methyltransferase like 11B 0.978634
CRTAC1 cartilage acidic protein 1 0.971169
NMU neuromedin U 0.971169
NOD1 nucleotide-binding oligomerization domain containing 1 0.948266
PLXNA4 plexin A4 0.918934
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.897579
PARD3B par-3 family cell polarity regulator beta 0.896302
IRF6 interferon regulatory factor 6 0.828142
FEM1C fem-1 homolog c (C. elegans) 0.819144
ADRBK2 adrenergic, beta, receptor kinase 2 0.80598
RNF152 ring finger protein 152 0.800256
ITGA11 integrin, alpha 11 0.795282
TMEM14A transmembrane protein 14A 0.792205
DIEXF digestive organ expansion factor homolog (zebrafish) 0.769617
ASIC2 acid sensing (proton gated) ion channel 2 0.761811
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.738443
DNER delta/notch-like EGF repeat containing 0.736216
RNF150 ring finger protein 150 0.735995
FLT1 fms-related tyrosine kinase 1 0.723979
SNX29 sorting nexin 29 0.715155
TDRP testis development related protein 0.714552
LOXHD1 lipoxygenase homology domains 1 0.713355
ALB albumin 0.712762
KLHDC4 kelch domain containing 4 0.708888
DCHS2 dachsous cadherin-related 2 0.706258
ARL5B ADP-ribosylation factor-like 5B 0.703873
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.703511
STARD13 StAR-related lipid transfer (START) domain containing 13 0.697901
ARHGAP10 Rho GTPase activating protein 10 0.693561
COL23A1 collagen, type XXIII, alpha 1 0.692423
MGLL monoglyceride lipase 0.683749
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.67576
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.671993
STX8 syntaxin 8 0.670943
TBX5 T-box 5 0.540011
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.502419