meprylcaine-6204 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the meprylcaine-6204 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
ARFRP1 ADP-ribosylation factor related protein 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPIN actin-related protein 2/3 complex inhibitor
ARR3 arrestin 3, retinal (X-arrestin)
ATN1 atrophin 1
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
C7ORF43 chromosome 7 open reading frame 43
CABP2 calcium binding protein 2
CAMKMT calmodulin-lysine N-methyltransferase
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDC25A cell division cycle 25A
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CENPO centromere protein O
DAPK3 death-associated protein kinase 3
DLX2 distal-less homeobox 2
DSC2 desmocollin 2
DSCAM Down syndrome cell adhesion molecule
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FAM189A2 family with sequence similarity 189, member A2
FGF6 fibroblast growth factor 6
FKBP8 FK506 binding protein 8, 38kDa
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GOSR1 golgi SNAP receptor complex member 1
GRM8 glutamate receptor, metabotropic 8
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HCFC1 host cell factor C1
HOXC8 homeobox C8
IL1B interleukin 1, beta
ITSN1 intersectin 1 (SH3 domain protein)
KAT2A K(lysine) acetyltransferase 2A
KDM6B lysine (K)-specific demethylase 6B
KREMEN2 kringle containing transmembrane protein 2
LMBR1L limb development membrane protein 1-like
LRRC14 leucine rich repeat containing 14
LRRC23 leucine rich repeat containing 23
MAX MYC associated factor X
MBD2 methyl-CpG binding domain protein 2
MEIS1 Meis homeobox 1
MFAP3L microfibrillar-associated protein 3-like
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MPPE1 metallophosphoesterase 1
MVP major vault protein
NF2 neurofibromin 2 (merlin)
NGLY1 N-glycanase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX2 paired box 2
PCIF1 PDX1 C-terminal inhibiting factor 1
PGBD5 piggyBac transposable element derived 5
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLCH1 phospholipase C, eta 1
POLL polymerase (DNA directed), lambda
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB11B RAB11B, member RAS oncogene family
RASA3 RAS p21 protein activator 3
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RPL10 ribosomal protein L10
RTN2 reticulon 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFTPB surfactant protein B
SGSH N-sulfoglucosamine sulfohydrolase
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC38A10 solute carrier family 38, member 10
SLMO1 slowmo homolog 1 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
SMTN smoothelin
SRP72 signal recognition particle 72kDa
STYK1 serine/threonine/tyrosine kinase 1
SUGP1 SURP and G patch domain containing 1
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNGR1 synaptogyrin 1
TBX19 T-box 19
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TK2 thymidine kinase 2, mitochondrial
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM14 tripartite motif containing 14
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBE3B ubiquitin protein ligase E3B
UBQLN4 ubiquilin 4
WIZ widely interspaced zinc finger motifs
ZBTB7A zinc finger and BTB domain containing 7A
ZER1 zyg-11 related, cell cycle regulator
ZMYND8 zinc finger, MYND-type containing 8
ZNF287 zinc finger protein 287
ZNF324 zinc finger protein 324
ZNF711 zinc finger protein 711

decreased expression

Symbol Name
AKIP1 A kinase (PRKA) interacting protein 1
AKR1C3 aldo-keto reductase family 1, member C3
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BTF3P11 basic transcription factor 3 pseudogene 11
C21ORF91 chromosome 21 open reading frame 91
CHMP6 charged multivesicular body protein 6
CLDN9 claudin 9
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DUSP5 dual specificity phosphatase 5
EDC4 enhancer of mRNA decapping 4
EXOC2 exocyst complex component 2
FAM86C1 family with sequence similarity 86, member C1
FANCE Fanconi anemia, complementation group E
FBRS fibrosin
GMEB1 glucocorticoid modulatory element binding protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR19 G protein-coupled receptor 19
GTF2I general transcription factor IIi
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HELZ helicase with zinc finger
HINFP histone H4 transcription factor
HIST1H2BC histone cluster 1, H2bc
HOOK1 hook microtubule-tethering protein 1
HOXC10 homeobox C10
HPSE heparanase
IKZF5 IKAROS family zinc finger 5 (Pegasus)
KCTD20 potassium channel tetramerization domain containing 20
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL12 kelch-like family member 12
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMCD1 LIM and cysteine-rich domains 1
LOC730101 uncharacterized LOC730101
LRP5L low density lipoprotein receptor-related protein 5-like
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAGEF1 melanoma antigen family F1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL2 mitochondrial ribosomal protein L2
NECAP2 NECAP endocytosis associated 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NUPL2 nucleoporin like 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARG poly (ADP-ribose) glycohydrolase
PCSK7 proprotein convertase subtilisin/kexin type 7
PDZRN3 PDZ domain containing ring finger 3
PEX26 peroxisomal biogenesis factor 26
PIBF1 progesterone immunomodulatory binding factor 1
PLD3 phospholipase D family, member 3
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRKX protein kinase, X-linked
PROCR protein C receptor, endothelial
PTPN9 protein tyrosine phosphatase, non-receptor type 9
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS17P5 ribosomal protein S17 pseudogene 5
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RWDD2A RWD domain containing 2A
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCAI suppressor of cancer cell invasion
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SF3A3 splicing factor 3a, subunit 3, 60kDa
SH2D4A SH2 domain containing 4A
SKA1 spindle and kinetochore associated complex subunit 1
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SREK1IP1 SREK1-interacting protein 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX5 syntaxin 5
STXBP2 syntaxin binding protein 2
THOP1 thimet oligopeptidase 1
TMUB2 transmembrane and ubiquitin-like domain containing 2
TOE1 target of EGR1, member 1 (nuclear)
TRAPPC13 trafficking protein particle complex 13
TWF2 twinfilin actin binding protein 2
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VGF VGF nerve growth factor inducible
VWA1 von Willebrand factor A domain containing 1
XYLT2 xylosyltransferase II
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF205 zinc finger protein 205
ZNF211 zinc finger protein 211
ZNF23 zinc finger protein 23
ZNF271P zinc finger protein 271, pseudogene
ZNF562 zinc finger protein 562
ZNF83 zinc finger protein 83
ZNHIT2 zinc finger, HIT-type containing 2