mephenytoin-6275 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the mephenytoin-6275 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM2 ADAM metallopeptidase domain 2
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AHI1 Abelson helper integration site 1
ALDOB aldolase B, fructose-bisphosphate
ALS2CL ALS2 C-terminal like
AMPD3 adenosine monophosphate deaminase 3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APC adenomatous polyposis coli
ATAT1 alpha tubulin acetyltransferase 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C7ORF43 chromosome 7 open reading frame 43
CA9 carbonic anhydrase IX
CALD1 caldesmon 1
CCDC132 coiled-coil domain containing 132
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CFAP45 cilia and flagella associated protein 45
CFLAR CASP8 and FADD-like apoptosis regulator
CHKB choline kinase beta
CLCN7 chloride channel, voltage-sensitive 7
CLN5 ceroid-lipofuscinosis, neuronal 5
CORT cortistatin
CPA4 carboxypeptidase A4
CSE1L CSE1 chromosome segregation 1-like (yeast)
DRD2 dopamine receptor D2
EDNRB endothelin receptor type B
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ETV7 ets variant 7
FAM134B family with sequence similarity 134, member B
FAM155A family with sequence similarity 155, member A
FSTL3 follistatin-like 3 (secreted glycoprotein)
GAS7 growth arrest-specific 7
GPR182 G protein-coupled receptor 182
HIC2 hypermethylated in cancer 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA1 high mobility group AT-hook 1
IPO8 importin 8
ITGA10 integrin, alpha 10
JAK2 Janus kinase 2
KLF2 Kruppel-like factor 2
LMF2 lipase maturation factor 2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP4 microtubule-associated protein 4
MID1 midline 1
MOCS1 molybdenum cofactor synthesis 1
MYOF myoferlin
NAAA N-acylethanolamine acid amidase
NCOA2 nuclear receptor coactivator 2
NCR2 natural cytotoxicity triggering receptor 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NPFFR1 neuropeptide FF receptor 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PACRG PARK2 co-regulated
PCLO piccolo presynaptic cytomatrix protein
PCNX pecanex homolog (Drosophila)
PLAGL2 pleiomorphic adenoma gene-like 2
PLK4 polo-like kinase 4
PLXNA1 plexin A1
PNPLA6 patatin-like phospholipase domain containing 6
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKCI protein kinase C, iota
PTGER3 prostaglandin E receptor 3 (subtype EP3)
QKI QKI, KH domain containing, RNA binding
RBBP9 retinoblastoma binding protein 9
RFTN1 raftlin, lipid raft linker 1
RIN2 Ras and Rab interactor 2
RTEL1 regulator of telomere elongation helicase 1
SDC2 syndecan 2
SIPA1L1 signal-induced proliferation-associated 1 like 1
SIRPA signal-regulatory protein alpha
SLC12A8 solute carrier family 12, member 8
SMAD3 SMAD family member 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
STK38L serine/threonine kinase 38 like
SUGP1 SURP and G patch domain containing 1
SUGP2 SURP and G patch domain containing 2
TAOK2 TAO kinase 2
TAS2R13 taste receptor, type 2, member 13
TAZ tafazzin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TTC28 tetratricopeptide repeat domain 28
TTC38 tetratricopeptide repeat domain 38
UTRN utrophin
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WNT6 wingless-type MMTV integration site family, member 6
ZCCHC14 zinc finger, CCHC domain containing 14
ZHX3 zinc fingers and homeoboxes 3
ZNF277 zinc finger protein 277
ZNF37BP zinc finger protein 37B, pseudogene
ZNF749 zinc finger protein 749
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ANKRD40 ankyrin repeat domain 40
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATF7IP2 activating transcription factor 7 interacting protein 2
BAHD1 bromo adjacent homology domain containing 1
BAK1 BCL2-antagonist/killer 1
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
C12ORF4 chromosome 12 open reading frame 4
CENPJ centromere protein J
CEP72 centrosomal protein 72kDa
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLDN15 claudin 15
CLDND1 claudin domain containing 1
CLSPN claspin
COL9A2 collagen, type IX, alpha 2
CPPED1 calcineurin-like phosphoesterase domain containing 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DDIT3 DNA-damage-inducible transcript 3
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DHRS11 dehydrogenase/reductase (SDR family) member 11
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNM1 dynamin 1
DVL1 dishevelled segment polarity protein 1
EDC3 enhancer of mRNA decapping 3
ELOVL4 ELOVL fatty acid elongase 4
EMD emerin
ETAA1 Ewing tumor-associated antigen 1
FAM184A family with sequence similarity 184, member A
FLCN folliculin
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLCE glucuronic acid epimerase
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
IFT81 intraflagellar transport 81
IL17RA interleukin 17 receptor A
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MBIP MAP3K12 binding inhibitory protein 1
MICALL2 MICAL-like 2
MITF microphthalmia-associated transcription factor
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL44 mitochondrial ribosomal protein L44
MSX1 msh homeobox 1
MXRA7 matrix-remodelling associated 7
NEK11 NIMA-related kinase 11
NPIPB15 nuclear pore complex interacting protein family, member B15
NPM3 nucleophosmin/nucleoplasmin 3
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PEX10 peroxisomal biogenesis factor 10
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
POMT2 protein-O-mannosyltransferase 2
POU2F1 POU class 2 homeobox 1
PQLC1 PQ loop repeat containing 1
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SCPEP1 serine carboxypeptidase 1
SLC41A3 solute carrier family 41, member 3
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SND1-IT1 SND1 intronic transcript 1
SPIDR scaffolding protein involved in DNA repair
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SSFA2 sperm specific antigen 2
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUN2 Sad1 and UNC84 domain containing 2
SYCP2 synaptonemal complex protein 2
TCTN2 tectonic family member 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TRIM25 tripartite motif containing 25
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
ULBP2 UL16 binding protein 2
ZC3H12A zinc finger CCCH-type containing 12A
ZC3H3 zinc finger CCCH-type containing 3
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF180 zinc finger protein 180
ZNF219 zinc finger protein 219
ZNF250 zinc finger protein 250
ZNF552 zinc finger protein 552
ZNF668 zinc finger protein 668
ZNF767P zinc finger family member 767, pseudogene
ZNF770 zinc finger protein 770
ZNF787 zinc finger protein 787
ZNF816 zinc finger protein 816
ZSCAN5A zinc finger and SCAN domain containing 5A