mental deterioration Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Loss of previously present mental abilities, generally in adults. (Human Phenotype Ontology, HP_0001268)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0001268
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Genes

54 genes associated with the mental deterioration phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
MYRF myelin regulatory factor 2.51912
FADS1 fatty acid desaturase 1 1.7083
SYK spleen tyrosine kinase 1.44665
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 1.19081
FADS2 fatty acid desaturase 2 1.13816
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 1.11203
NALCN sodium leak channel, non selective 1.0674
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.06177
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 1.04239
ELOVL2 ELOVL fatty acid elongase 2 1.03761
GRIK2 glutamate receptor, ionotropic, kainate 2 1.00352
SETBP1 SET binding protein 1 1.00059
HRH4 histamine receptor H4 0.994211
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 0.977911
CSMD1 CUB and Sushi multiple domains 1 0.9776
AR androgen receptor 0.960972
KIF26B kinesin family member 26B 0.957533
MAP7 microtubule-associated protein 7 0.906281
PRR11 proline rich 11 0.876191
RSPO3 R-spondin 3 0.851472
STK32B serine/threonine kinase 32B 0.836232
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.835282
ADRA1A adrenoceptor alpha 1A 0.832497
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.83069
NAV2 neuron navigator 2 0.829801
TMEM132D transmembrane protein 132D 0.827192
MACROD2 MACRO domain containing 2 0.825497
CCDC6 coiled-coil domain containing 6 0.817516
SH3PXD2A SH3 and PX domains 2A 0.816759
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.812214
BAALC brain and acute leukemia, cytoplasmic 0.810722
SLIT2 slit homolog 2 (Drosophila) 0.799025
PARK2 parkin RBR E3 ubiquitin protein ligase 0.783563
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.776638
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.767198
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.761926
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.754763
ZNF626 zinc finger protein 626 0.753784
C6ORF10 chromosome 6 open reading frame 10 0.752816
NPAS3 neuronal PAS domain protein 3 0.735423
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.732349
N4BP2 NEDD4 binding protein 2 0.717572
NEGR1 neuronal growth regulator 1 0.709012
HEPH hephaestin 0.669923
AKAP10 A kinase (PRKA) anchor protein 10 0.665514
SASS6 spindle assembly 6 homolog (C. elegans) 0.647367
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.646866
EFTUD1 elongation factor Tu GTP binding domain containing 1 0.642942
EPHB1 EPH receptor B1 0.641507
MGST2 microsomal glutathione S-transferase 2 0.632852
LOC643542 uncharacterized LOC643542 0.628362
LIPK lipase, family member K 0.583059
C11ORF30 chromosome 11 open reading frame 30 0.578475
EBF1 early B-cell factor 1 0.57293