melanoma Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)|A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain. (Experimental Factor Ontology, EFO_0000756)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa05218.html
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Genes

71 proteins participating in the melanoma pathway from the KEGG Pathways dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARAF A-Raf proto-oncogene, serine/threonine kinase
BAD BCL2-associated agonist of cell death
BRAF B-Raf proto-oncogene, serine/threonine kinase
CCND1 cyclin D1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
EGF epidermal growth factor
EGFR epidermal growth factor receptor
FGF1 fibroblast growth factor 1 (acidic)
FGF10 fibroblast growth factor 10
FGF11 fibroblast growth factor 11
FGF12 fibroblast growth factor 12
FGF13 fibroblast growth factor 13
FGF14 fibroblast growth factor 14
FGF16 fibroblast growth factor 16
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF20 fibroblast growth factor 20
FGF21 fibroblast growth factor 21
FGF22 fibroblast growth factor 22
FGF23 fibroblast growth factor 23
FGF3 fibroblast growth factor 3
FGF4 fibroblast growth factor 4
FGF5 fibroblast growth factor 5
FGF6 fibroblast growth factor 6
FGF7 fibroblast growth factor 7
FGF8 fibroblast growth factor 8 (androgen-induced)
FGF9 fibroblast growth factor 9
FGFR1 fibroblast growth factor receptor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
KRAS Kirsten rat sarcoma viral oncogene homolog
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MITF microphthalmia-associated transcription factor
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PTEN phosphatase and tensin homolog
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
TP53 tumor protein p53