medullary thyroid carcinoma cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A cell ot a type of thyroid gland carcinoma that contains amyloid deposits and parafollicular cells and secretes calcitonin. It occurs in both an autosomal dominant form as a component of multiple endocrine neoplasia, types II and III, and in a nonfamilial form. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000184)
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Genes

151 proteins co-occuring with the tissue medullary thyroid carcinoma cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
RET ret proto-oncogene 2.18135
CALCA calcitonin-related polypeptide alpha 2.07654
ASCL1 achaete-scute family bHLH transcription factor 1 1.50339
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4 1.39009
CHGA chromogranin A 1.12128
SSTR2 somatostatin receptor 2 1.10181
SSTR5 somatostatin receptor 5 1.04445
ZHX2 zinc fingers and homeoboxes 2 0.990639
SSTR1 somatostatin receptor 1 0.971984
PSPN persephin 0.90924
KIF15 kinesin family member 15 0.880781
SST somatostatin 0.772759
KIFC1 kinesin family member C1 0.7595
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.742152
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.712139
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.691268
PARP1 poly (ADP-ribose) polymerase 1 0.670878
GAB1 GRB2-associated binding protein 1 0.66071
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.640833
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.624658
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.603697
MIR183 microRNA 183 0.593649
BMF Bcl2 modifying factor 0.588832
NOTCH1 notch 1 0.578016
TRAF3 TNF receptor-associated factor 3 0.566428
HES2 hes family bHLH transcription factor 2 0.562042
TPX2 TPX2, microtubule-associated 0.555274
GAST gastrin 0.549312
ATF1 activating transcription factor 1 0.531089
IFI16 interferon, gamma-inducible protein 16 0.529903
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.521617
ARHGAP18 Rho GTPase activating protein 18 0.507849
HES6 hes family bHLH transcription factor 6 0.497657
SDCBP syndecan binding protein (syntenin) 0.491791
STARD13 StAR-related lipid transfer (START) domain containing 13 0.488667
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.478145
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.477367
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 0.457987
ESM1 endothelial cell-specific molecule 1 0.446422
CCK cholecystokinin 0.43146
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.423818
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.409351
RPS6 ribosomal protein S6 0.405935
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.40025
ZAK sterile alpha motif and leucine zipper containing kinase AZK 0.40025
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 0.375368
ARTN artemin 0.372743
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.370683
CCND1 cyclin D1 0.370121
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.36956
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.368998
TPCN1 two pore segment channel 1 0.36526
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.364886
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.358546
IL2 interleukin 2 0.34371
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.34371
EGFR epidermal growth factor receptor 0.33156
CALCR calcitonin receptor 0.330643
CASR calcium-sensing receptor 0.33046
RREB1 ras responsive element binding protein 1 0.32817
CD177 CD177 molecule 0.318042
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.310421
GDNF glial cell derived neurotrophic factor 0.298165
ADAP1 ArfGAP with dual PH domains 1 0.296013
NTS neurotensin 0.292079
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 0.284607
CCKBR cholecystokinin B receptor 0.282483
PTTG1 pituitary tumor-transforming 1 0.279659
KRT20 keratin 20, type I 0.278955
ICK intestinal cell (MAK-like) kinase 0.266069
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.265381
CD4 CD4 molecule 0.258243
ARF6 ADP-ribosylation factor 6 0.256902
LAMA2 laminin, alpha 2 0.256568
CCNB1 cyclin B1 0.253578
DUSP1 dual specificity phosphatase 1 0.249329
STMN2 stathmin 2 0.238481
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.236921
INSL3 insulin-like 3 (Leydig cell) 0.236921
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 0.226796
S100A13 S100 calcium binding protein A13 0.226283
NRTN neurturin 0.221989
USF2 upstream transcription factor 2, c-fos interacting 0.215002
CALCB calcitonin-related polypeptide beta 0.204628
RPIA ribose 5-phosphate isomerase A 0.202401
MBOAT4 membrane bound O-acyltransferase domain containing 4 0.201103
CD58 CD58 molecule 0.20072
FGG fibrinogen gamma chain 0.199876
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 0.199266
PAX1 paired box 1 0.199214
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.198945
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.198861
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.198786
ALOX15 arachidonate 15-lipoxygenase 0.198056
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.197998
TRAC T cell receptor alpha constant 0.197584
CD48 CD48 molecule 0.197111
GHRL ghrelin/obestatin prepropeptide 0.196914
SNED1 sushi, nidogen and EGF-like domains 1 0.196777
CST3 cystatin C 0.196619
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.19651
CD86 CD86 molecule 0.19638
BCO1 beta-carotene oxygenase 1 0.196259
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 0.196074
MLNR motilin receptor 0.196054
SPINK1 serine peptidase inhibitor, Kazal type 1 0.196012
RAMP3 receptor (G protein-coupled) activity modifying protein 3 0.195965
CD244 CD244 molecule, natural killer cell receptor 2B4 0.195939
USF1 upstream transcription factor 1 0.195764
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.195694
PAX9 paired box 9 0.195639
GFRA1 GDNF family receptor alpha 1 0.195607
CD80 CD80 molecule 0.195596
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.195519
NPB neuropeptide B 0.194873
MBP myelin basic protein 0.194679
HSPA4 heat shock 70kDa protein 4 0.194248
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.194209
FRS2 fibroblast growth factor receptor substrate 2 0.194183
NPAT nuclear protein, ataxia-telangiectasia locus 0.194058
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.193808
CDR1 cerebellar degeneration-related protein 1, 34kDa 0.193794
GRP gastrin-releasing peptide 0.193315
ENO2 enolase 2 (gamma, neuronal) 0.193227
TUBA1A tubulin, alpha 1a 0.193154
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.19296
FST follistatin 0.192669
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.19224
TRH thyrotropin-releasing hormone 0.192117
CST4 cystatin S 0.190994
TNF tumor necrosis factor 0.190639
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.190582
CHGB chromogranin B 0.190572
TPH1 tryptophan hydroxylase 1 0.190022
GCG glucagon 0.186406
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.185704
GRAP2 GRB2-related adaptor protein 2 0.184555
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.181546
GCGR glucagon receptor 0.181317
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.180713
PCSK2 proprotein convertase subtilisin/kexin type 2 0.178796
PCSK1 proprotein convertase subtilisin/kexin type 1 0.176182
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.171884
PAM peptidylglycine alpha-amidating monooxygenase 0.171844
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.171119
ICAM1 intercellular adhesion molecule 1 0.170534
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 0.170491
SYP synaptophysin 0.170405
MCF2 MCF.2 cell line derived transforming sequence 0.169168
ENGASE endo-beta-N-acetylglucosaminidase 0.168663
NF1 neurofibromin 1 0.168141