medium spiny neuron Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A special type of inhibitory cells representing approximately 90% of the neurons within the corpus striatum of the basal ganglia. They play a key role in initiating and controlling movements of the body, limbs and eyes. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004778)
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Genes

197 proteins co-occuring with the tissue medium spiny neuron in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 2.33852
PDE10A phosphodiesterase 10A 2.20138
DRD2 dopamine receptor D2 1.95198
HTT huntingtin 1.85688
DRD1 dopamine receptor D1 1.79549
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.60316
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 1.46961
GPR88 G protein-coupled receptor 88 1.35313
CNR1 cannabinoid receptor 1 (brain) 1.35132
PDYN prodynorphin 1.30793
STK25 serine/threonine kinase 25 1.29624
BDNF brain-derived neurotrophic factor 1.16959
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.1421
RPL10A ribosomal protein L10a 1.06426
DGKB diacylglycerol kinase, beta 90kDa 1.06118
PDE2A phosphodiesterase 2A, cGMP-stimulated 1.05721
TAC1 tachykinin, precursor 1 1.05677
PVALB parvalbumin 1.05325
CALB1 calbindin 1, 28kDa 1.05193
ADORA2A adenosine A2a receptor 1.04973
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.0484
ARPP19 cAMP-regulated phosphoprotein, 19kDa 1.03741
PENK proenkephalin 1.02863
RGS9 regulator of G-protein signaling 9 1.0225
SLK STE20-like kinase 1.01768
CREB1 cAMP responsive element binding protein 1 1.01243
TH tyrosine hydroxylase 1.00981
GRM5 glutamate receptor, metabotropic 5 1.00545
GRM1 glutamate receptor, metabotropic 1 1.00065
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.964199
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.936629
TOR1A torsin family 1, member A (torsin A) 0.923767
CDK5 cyclin-dependent kinase 5 0.905404
CNRIP1 cannabinoid receptor interacting protein 1 0.876129
ADCY2 adenylate cyclase 2 (brain) 0.830709
DARS aspartyl-tRNA synthetase 0.820248
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.818576
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.811891
EMX1 empty spiracles homeobox 1 0.802293
XYLB xylulokinase homolog (H. influenzae) 0.801042
SNX3 sorting nexin 3 0.795208
CHRM4 cholinergic receptor, muscarinic 4 0.780232
SLC35D3 solute carrier family 35, member D3 0.777325
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.765296
PLXND1 plexin D1 0.761984
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.754124
SCRT1 scratch family zinc finger 1 0.75247
FOS FBJ murine osteosarcoma viral oncogene homolog 0.749992
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.740915
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 0.738854
OPRM1 opioid receptor, mu 1 0.72322
FOXP2 forkhead box P2 0.721166
RIPK4 receptor-interacting serine-threonine kinase 4 0.70886
ZDHHC17 zinc finger, DHHC-type containing 17 0.674543
PLA2G12A phospholipase A2, group XIIA 0.672506
DST dystonin 0.665995
RASD2 RASD family, member 2 0.665182
IFT57 intraflagellar transport 57 0.66071
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.655024
LRRK2 leucine-rich repeat kinase 2 0.646505
SNPH syntaphilin 0.628293
CHAT choline O-acetyltransferase 0.627485
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.625869
SNX2 sorting nexin 2 0.62385
KALRN kalirin, RhoGEF kinase 0.622639
MSN moesin 0.6182
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.612152
LMBRD1 LMBR1 domain containing 1 0.606112
MYT1L myelin transcription factor 1-like 0.604099
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.603295
ASIP agouti signaling protein 0.585625
GYPE glycophorin E (MNS blood group) 0.585224
IL31RA interleukin 31 receptor A 0.58242
TNIK TRAF2 and NCK interacting kinase 0.576015
MCHR1 melanin-concentrating hormone receptor 1 0.574416
PPP1R3A protein phosphatase 1, regulatory subunit 3A 0.57082
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.570021
BICD1 bicaudal D homolog 1 (Drosophila) 0.569222
RGS7BP regulator of G-protein signaling 7 binding protein 0.566428
ENSA endosulfine alpha 0.555671
FAT2 FAT atypical cadherin 2 0.549312
POLE polymerase (DNA directed), epsilon, catalytic subunit 0.546533
RHEB Ras homolog enriched in brain 0.546136
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.533856
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 0.53267
POLM polymerase (DNA directed), mu 0.528719
CDH16 cadherin 16, KSP-cadherin 0.520435
AKAP9 A kinase (PRKA) anchor protein 9 0.520435
PITX3 paired-like homeodomain 3 0.503926
CALY calcyon neuron-specific vesicular protein 0.500398
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 0.497266
FOXP1 forkhead box P1 0.494528
NLGN3 neuroligin 3 0.494136
GCDH glutaryl-CoA dehydrogenase 0.485156
MAPK8 mitogen-activated protein kinase 8 0.482038
AKAP5 A kinase (PRKA) anchor protein 5 0.472704
MORF4 mortality factor 4 (pseudogene) 0.470375
CDH8 cadherin 8, type 2 0.468048
NPS neuropeptide S 0.466111
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.4634
ADCY8 adenylate cyclase 8 (brain) 0.461852
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.460305
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.45567
MINK1 misshapen-like kinase 1 0.445268
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 0.443731
CALB2 calbindin 2 0.441042
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 0.43414
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.432225
PAPD7 PAP associated domain containing 7 0.428783
NPAS4 neuronal PAS domain protein 4 0.426872
CDSN corneodesmosin 0.425344
TYRO3 TYRO3 protein tyrosine kinase 0.421529
LEMD3 LEM domain containing 3 0.41848
RELN reelin 0.411631
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.410491
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.409731
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.404418
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.40328
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.399114
CPLX1 complexin 1 0.398357
SNN stannin 0.381755
SGCE sarcoglycan, epsilon 0.375368
GRIK1 glutamate receptor, ionotropic, kainate 1 0.370496
HIP1 huntingtin interacting protein 1 0.370496
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.36825
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 0.365633
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.36302
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.361901
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 0.360409
JUN jun proto-oncogene 0.360036
KRTAP1-3 keratin associated protein 1-3 0.355942
GSX2 GS homeobox 2 0.351485
FEZF2 FEZ family zinc finger 2 0.351114
CBLN1 cerebellin 1 precursor 0.350001
NOG noggin 0.34963
KRTAP1-1 keratin associated protein 1-1 0.348889
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.341495
GUSB glucuronidase, beta 0.33965
PINK1 PTEN induced putative kinase 1 0.338545
H3F3A H3 histone, family 3A 0.33744
H3F3B H3 histone, family 3B (H3.3B) 0.33744
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.337072
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.336704
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.332661
RAP1GAP RAP1 GTPase activating protein 0.331194
LHX6 LIM homeobox 6 0.33046
NKX2-1 NK2 homeobox 1 0.330094
SCG2 secretogranin II 0.329727
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 0.32497
RNASE3 ribonuclease, RNase A family, 3 0.324605
MGAT4C MGAT4 family, member C 0.317679
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.299601
RDX radixin 0.299601
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.299601
LSR lipolysis stimulated lipoprotein receptor 0.296372
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.292436
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.292436
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.292079
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.291008
MAOB monoamine oxidase B 0.288158
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 0.287447
OSCAR osteoclast associated, immunoglobulin-like receptor 0.287447
TFDP3 transcription factor Dp family, member 3 0.283899
ELL elongation factor RNA polymerase II 0.283899
MC4R melanocortin 4 receptor 0.283899
GDF6 growth differentiation factor 6 0.283545
CHRM1 cholinergic receptor, muscarinic 1 0.283545
ILK integrin-linked kinase 0.28213
KIF3A kinesin family member 3A 0.28107
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.278955
DLX1 distal-less homeobox 1 0.2779
MGAM maltase-glucoamylase 0.273696
NPY neuropeptide Y 0.268137
SIM1 single-minded family bHLH transcription factor 1 0.267446
SYCN syncollin 0.260267
SNCB synuclein, beta 0.259254
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.256902
OTP orthopedia homeobox 0.25457
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.249977
GRM2 glutamate receptor, metabotropic 2 0.249006
SST somatostatin 0.247079
EGR1 early growth response 1 0.243918
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.243294
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.237216
NPEPPS aminopeptidase puromycin sensitive 0.237216
MECP2 methyl CpG binding protein 2 0.233446
SP8 Sp8 transcription factor 0.231206
ALAS2 5'-aminolevulinate synthase 2 0.230656
GDA guanine deaminase 0.225144
GALR1 galanin receptor 1 0.223662
ISL1 ISL LIM homeobox 1 0.22246
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.221291
ADCY1 adenylate cyclase 1 (brain) 0.219707
RPS6 ribosomal protein S6 0.21883
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.218613
SYN1 synapsin I 0.217762
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.214954